Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor. (Q37341230)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19056433%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

review article

1 reference

title

Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor (English)

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18 January 2020

2

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18 January 2020

author name string

Yi-Ping Rong

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19056433%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Vivien C Yee

series ordinal

3

1 reference

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18 January 2020

Clark W Distelhorst

series ordinal

4

1 reference

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18 January 2020

language of work or name

English

0 references

publication date

12 November 2008

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Biochimica et Biophysica Acta

18 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19056433%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

volume

1793

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18 January 2020

issue

6

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18 January 2020

page(s)

971-978

1 reference

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Solution Structure of the Integral Human Membrane Protein VDAC-1 in Detergent Micelles

18 January 2020

cites work

1 reference

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6 September 2017

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Anti-apoptotic therapy with a Tat fusion protein protects against excitotoxic insults in vitro and in vivo

6 September 2017

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6 September 2017

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Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis

6 September 2017

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Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

6 September 2017

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The Bcl-2 apoptotic switch in cancer development and therapy

6 September 2017

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Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia

6 September 2017

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IP3 receptors in cell survival and apoptosis: Ca2+ release and beyond

6 September 2017

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

6 September 2017

1 reference

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NMR structural investigation of the mitochondrial outer membrane protein VDAC and its interaction with antiapoptotic Bcl-xL.

6 September 2017

1 reference

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Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group

6 September 2017

1 reference

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Bcl-2 and Ca2+ homeostasis in the endoplasmic reticulum

6 September 2017

1 reference

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Bcl-2 differentially regulates Ca2+ signals according to the strength of T cell receptor activation

6 September 2017

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Promoting apoptosis as a strategy for cancer drug discovery

6 September 2017

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The inositol 1,4,5-trisphosphate receptors

6 September 2017

1 reference

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Delivery of TAT/PTD-fused proteins/peptides to islets via pancreatic duct.

6 September 2017

1 reference

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

6 September 2017

1 reference

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Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

6 September 2017

1 reference

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The RAF proteins take centre stage

6 September 2017

1 reference

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Delivery of Bcl-XL or its BH4 domain by protein transduction inhibits apoptosis in human islets.

6 September 2017

1 reference

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Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.

6 September 2017

1 reference

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FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?

6 September 2017

1 reference

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Domoic acid enhances Bcl-2-calcineurin-inositol-1,4,5-trisphosphate receptor interactions and delayed neuronal death in rat brain slices

6 September 2017

1 reference

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Inositol 1,4,5-trisphosphate receptors as signal integrators

6 September 2017

1 reference

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IP(3) receptors: the search for structure.

6 September 2017

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Interaction of bcl-2 with Paxillin through its BH4 domain is important during ureteric bud branching

6 September 2017

1 reference

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The Bcl-2 family: roles in cell survival and oncogenesis.

6 September 2017

1 reference

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Calcineurin and intracellular Ca2+-release channels: regulation or association?

6 September 2017

1 reference

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Ca2+/calcineurin signalling in cells of the immune system

6 September 2017

1 reference

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Regulation of cell death: the calcium-apoptosis link

6 September 2017

1 reference

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Calcium signaling and apoptosis

6 September 2017

1 reference

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

6 September 2017

1 reference

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The Bcl2 family: regulators of the cellular life-or-death switch

6 September 2017

1 reference

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Oblimersen Bcl-2 antisense: facilitating apoptosis in anticancer treatment

6 September 2017

1 reference

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Paxillin: a focal adhesion-associated adaptor protein

6 September 2017

1 reference

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The versatility and universality of calcium signalling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

Solution structure of the antiapoptotic protein bcl-2

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

Apoptosis, cell adhesion and the extracellular matrix in the three-dimensional growth of multicellular tumor spheroids

6 September 2017

1 reference

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Mitochondria as the central control point of apoptosis

6 September 2017

1 reference

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Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

6 September 2017

1 reference

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BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

6 September 2017

1 reference

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Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

6 September 2017

1 reference

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Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription

6 September 2017

1 reference

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Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

6 September 2017

1 reference

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BCL-2 family: regulators of cell death

6 September 2017

1 reference

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The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

6 September 2017

1 reference

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Inhibition of Bax channel-forming activity by Bcl-2

6 September 2017

1 reference

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Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2.

6 September 2017

1 reference

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The complexity of Raf-1 regulation

6 September 2017

1 reference

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Bcl-2 targets the protein kinase Raf-1 to mitochondria

6 September 2017

1 reference

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Suppression of TNF-alpha-induced apoptosis by NF-kappaB

6 September 2017

1 reference

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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

6 September 2017

1 reference

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

6 September 2017

1 reference

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Functional dissection of the human Bc12 protein: sequence requirements for inhibition of apoptosis

6 September 2017

1 reference

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Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux

6 September 2017

1 reference

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Apoptosis in the pathogenesis and treatment of disease

6 September 2017

1 reference

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Induction of apoptosis by the Bcl-2 homologue Bak

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

ras oncogenes in human cancer: a review

6 September 2017

1 reference

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Calcineurin B1 is essential for positive but not negative selection during thymocyte development

6 September 2017

1 reference

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Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

Anti-apoptotic peptides protect against radiation-induced cell death

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R

14 September 2017

1 reference

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Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L).

14 September 2017

1 reference

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BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

The extracellular matrix as a cell survival factor

14 September 2017

1 reference

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Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

Linkage of the BH4 domain of Bcl-2 and the nuclear factor kappaB signaling pathway for suppression of apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

Bc1-2, Raf-1 and mitochondrial regulation of apoptosis

28 September 2017

1 reference

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Differential regulation of discrete apoptotic pathways by Ras.

28 September 2017

1 reference

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Conversion of Bcl-2 to a Bax-like death effector by caspases

28 September 2017

1 reference

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Anchorage dependence, integrins, and apoptosis

28 September 2017

1 reference

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Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.

28 September 2017

1 reference

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Detrimental effects of antiapoptotic treatments in spinal cord injury.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

Suppression of transcription factor NF-kappaB activity by Bcl-2 protein in NIH3T3 cells: implication of a novel NF-kappaB p50-Bcl-2 complex for the anti-apoptotic function of Bcl-2.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

Focal adhesion kinase, paxillin, and bcl-2: analysis of expression, phosphorylation, and association during morphogenesis.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

A biochemical function for ras--at last

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store content

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

TAT-BH4 counteracts Abeta toxicity on capillary endothelium

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

BH4 peptide derivative from Bcl-xL attenuates ischemia/reperfusion injury thorough anti-apoptotic mechanism in rat hearts

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

Exogenous BH4/Bcl-2 peptide reverts coronary endothelial cell apoptosis induced by oxidative stress

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

Identification of chelerythrine as an inhibitor of BclXL function

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

In vitro hypoxia and excitotoxicity in human brain induce calcineurin-Bcl-2 interactions

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

Bcl-2 does not require Raf kinase activity for its death-protective function

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

Evidence for alpha-helical conformation of an essential N-terminal region in the human Bcl2 protein.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

Bcl-2, via Its BH4 Domain, Blocks Apoptotic Signaling Mediated by Mitochondrial Ras

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

Calcium - a life and death signal

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674874

TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo

3 December 2018

1 reference

12 December 2020

Upgrading the BCL-2 network

1 reference

12 December 2020

bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

1 reference

12 December 2020

Failure of Bcl-2 family members to interact with Apaf-1 in normal and apoptotic cells

1 reference

12 December 2020

Suppression of IP3-mediated calcium release and apoptosis by Bcl-2 involves the participation of protein phosphatase 1

1 reference

12 December 2020

Bcl-2 counters apoptosis by Bax heterodimerization-dependent and -independent mechanisms in the T-cell lineage

1 reference

12 December 2020

10.1016/J.BBAMCR.2008.10.015

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19056433%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19056433%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

19056433

1 reference