Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor (Q37346761)

19 August 2017

Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor (English)

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experimental autoimmune encephalomyelitis

19 August 2017

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18

Michael R Hayden

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19 August 2017

Joel Kaye

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19 August 2017

Victor Piryatinsky

2

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19 August 2017

Tal Birnberg

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19 August 2017

Tal Hingaly

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19 August 2017

Emanuel Raymond

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Rina Kashi

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19 August 2017

Einat Amit-Romach

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19 August 2017

Ignacio S Caballero

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19 August 2017

Fadi Towfic

9

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19 August 2017

Mark A Ator

10

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19 August 2017

Efrat Rubinstein

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19 August 2017

Daphna Laifenfeld

12

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19 August 2017

Aric Orbach

13

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19 August 2017

Doron Shinar

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19 August 2017

Yael Marantz

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19 August 2017

Iris Grossman

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Volker Knappertz

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19 August 2017

Ralph Laufer

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19 August 2017

language of work or name

English

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publication date

26 September 2016

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Proceedings of the National Academy of Sciences of the United States of America

19 August 2017

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19 August 2017

113

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19 August 2017

41

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19 August 2017

E6145-E6152

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describes a project that uses

19 August 2017

limma

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22 June 2022

https://europepmc.org/article/PMC/5068259

inferred from PubMed Central ID database lookup

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Laquinimod delays and suppresses nephritis in lupus-prone mice and affects both myeloid and lymphoid immune cells

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Therapeutic laquinimod treatment decreases inflammation, initiates axon remyelination, and improves motor deficit in a mouse model of multiple sclerosis

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Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo

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Placebo-controlled trial of oral laquinimod in multiple sclerosis: MRI evidence of an effect on brain tissue damage

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6 September 2017

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Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling.

6 September 2017

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Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination

6 September 2017

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Aryl hydrocarbon receptor controls regulatory CD4+ T cell function.

6 September 2017

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Laquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity

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Placebo-controlled trial of oral laquinimod for multiple sclerosis

6 September 2017

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Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor

6 September 2017

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In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling

6 September 2017

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An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis

6 September 2017

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The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27.

6 September 2017

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Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells

6 September 2017

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Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells.

6 September 2017

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Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor

6 September 2017

1 reference

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2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses tumor necrosis factor-alpha and anti-CD40-induced activation of NF-kappaB/Rel in dendritic cells: p50 homodimer activation is not affected

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5068259

Laquinimod prevents inflammation-induced synaptic alterations occurring in experimental autoimmune encephalomyelitis.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5068259

Kinetics of proinflammatory monocytes in a model of multiple sclerosis and its perturbation by laquinimod.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5068259

Oral treatment with laquinimod augments regulatory T-cells and brain-derived neurotrophic factor expression and reduces injury in the CNS of mice with experimental autoimmune encephalomyelitis.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5068259

Modulation of autoimmune demyelination by laquinimod via induction of brain-derived neurotrophic factor.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5068259

Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5068259

Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5068259

Suppression of experimental autoimmune neuritis by ABR-215062 is associated with altered Th1/Th2 balance and inhibited migration of inflammatory cells into the peripheral nerve tissue

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5068259

A randomized placebo-controlled phase III trial of oral laquinimod for multiple sclerosis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5068259

Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro

20 October 2018

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12 December 2020

Laquinimod exerts strong clinical and immunomodulatory effects in Lewis rat experimental autoimmune neuritis

1 reference

12 December 2020

Laquinimod ameliorates spontaneous colitis in interleukin-10-gene-deficient mice with improved barrier function

1 reference

12 December 2020

Ultraviolet light converts propranolol, a nonselective β-blocker and potential lupus-inducing drug, into a proinflammatory AhR ligand

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1607843113

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19 August 2017

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19 August 2017

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