Signaling factors in the mechanism of ammonia neurotoxicity (Q37357143)

19 August 2017

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title

Signaling factors in the mechanism of ammonia neurotoxicity (English)

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19 August 2017

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M D Norenberg

1

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PubMed ID

19104923

19 August 2017

K V Rama Rao

series ordinal

2

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PubMed ID

19104923

19 August 2017

A R Jayakumar

series ordinal

3

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19 August 2017

23 December 2008

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19 August 2017

Metabolic Brain Disease

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19 August 2017

24

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19 August 2017

1

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19 August 2017

103-117

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https://scigraph.springernature.com/pub.10.1007/s11011-008-9113-6

19 August 2017

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cites work

Characterization of L-glutamate uptake into and release from astrocytes and neurons cultured from different brain regions

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11011-008-9113-6

Swelling, acidosis, and irreversible damage of glial cells from exposure to arachidonic acid in vitro.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11011-008-9113-6

The mitochondrial permeability transition.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11011-008-9113-6

Acute liver failure and hyperammonemia increase peripheral-type benzodiazepine receptor binding and pregnenolone synthesis in mouse brain

21 January 2018

1 reference

12 December 2020

Gliotoxic action of glutamate on cultured astrocytes

1 reference

12 December 2020

NF-kappaB activation: the I kappaB kinase revealed?

1 reference

12 December 2020

Cerebral energy metabolism in hepatic encephalopathy and hyperammonemia

1 reference

12 December 2020

Manganese induces the mitochondrial permeability transition in cultured astrocytes

1 reference

12 December 2020

Oxidative stress in the pathogenesis of hepatic encephalopathy

1 reference

12 December 2020

Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow

1 reference

12 December 2020

Electron microscopic study of brain capillaries in cerebral edema from fulminant hepatic failure

1 reference

12 December 2020

Inhibition of glutamine transport into mitochondria protects astrocytes from ammonia toxicity

1 reference

12 December 2020

EFFECT OF AN INHIBITOR OF GLUTAMINE SYNTHESIS (METHIONINE SULFOXIMINE) ON AMMONIA TOXICITY AND METABOLISM

1 reference

12 December 2020

Azoxymethane-induced fulminant hepatic failure in C57BL/6J mice: characterization of a new animal model.

1 reference

12 December 2020

Ammonia downregulates GLAST mRNA glutamate transporter in rat astrocyte cultures

1 reference

12 December 2020

Nuclear factor-kappa B: from clone to clinic

1 reference

12 December 2020

Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity

1 reference

12 December 2020

Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH.

1 reference

12 December 2020

Mitochondrial permeability transition is a central coordinating event of apoptosis

1 reference

12 December 2020

Development of the blood-brain barrier

1 reference

12 December 2020

Progressive decrease of cerebral cytochrome C oxidase activity in sparse-fur mice: role of acetyl-L-carnitine in restoring the ammonia-induced cerebral energy depletion.

1 reference

12 December 2020

Liver derived pro-inflammatory cytokines may be important in producing intracranial hypertension in acute liver failure

1 reference

12 December 2020

Effect of ascorbic acid on hyperoxic rat astrocytes

1 reference

12 December 2020

New concepts in the mechanism of ammonia-induced astrocyte swelling

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12 December 2020

Calcium-dependent production of reactive oxygen species is involved in neuronal damage induced during glycolysis inhibition in cultured hippocampal neurons.

1 reference

12 December 2020

Mechanisms of ammonia-induced astrocyte swelling

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12 December 2020

Glutamatergic synaptic dysfunction in hyperammonemic syndromes

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12 December 2020

Ammonia-induced production of free radicals in primary cultures of rat astrocytes

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12 December 2020

Regulation of the expression of inducible nitric oxide synthase

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12 December 2020

Hepatic encephalopathy and cerebral edema

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12 December 2020

Role of oxidative stress in the ammonia-induced mitochondrial permeability transition in cultured astrocytes

1 reference

12 December 2020

Correlation between ammonia levels and the severity of hepatic encephalopathy.

1 reference

12 December 2020

Synaptic transmission in the hippocampus: critical role for glial cells

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12 December 2020

Phospholipid degradation and cellular edema induced by free radicals in brain cortical slices.

1 reference

12 December 2020

Effect of antioxidants on ammonia induced CNS-renal pathobiology in sheep.

1 reference

12 December 2020

Protein tyrosine nitration in hyperammonemia and hepatic encephalopathy

1 reference

12 December 2020

Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for tumor necrosis factor-alpha aopototic signaling

1 reference

12 December 2020

Pathogenetic interplay between osmotic and oxidative stress: the hepatic encephalopathy paradigm

1 reference

12 December 2020

Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells

1 reference

12 December 2020

Cerebral blood flow and the development of ammonia-induced brain edema in rats after portacaval anastomosis.

1 reference

12 December 2020

Extracellular brain glutamate during acute liver failure and during acute hyperammonemia simulating acute liver failure: an experimental study based on in vivo brain dialysis

1 reference

12 December 2020

Glial contributions to excitatory neurotransmission in cultured hippocampal cells.

1 reference

12 December 2020

Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia

1 reference

12 December 2020

Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function

1 reference

12 December 2020

The pathophysiology of brain edema in acute liver failure

1 reference

12 December 2020

Astroglial dysfunction in hepatic encephalopathy

1 reference

12 December 2020

Fulminant hepatic failure: summary of a workshop

1 reference

12 December 2020

A role for phosphorylation and degradation in the control of NF-kappa B activity.

1 reference

12 December 2020

Oxidants as stimulators of signal transduction

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12 December 2020

Astrocyte-endothelial interactions at the blood-brain barrier

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12 December 2020

Morphometric and densitometric investigations of protoplasmic astrocytes and neurons in human hepatic encephalopathy.

1 reference

12 December 2020

Glutamine: a Trojan horse in ammonia neurotoxicity

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12 December 2020

The role of arachidonic acid and oxygen radical metabolites in the pathogenesis of vasogenic brain edema and astrocytic swelling

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12 December 2020

Increased brain uptake of gamma-aminobutyric acid in a rabbit model of hepatic encephalopathy.

1 reference

12 December 2020

Fine structural localization of glutamine synthetase in astrocytes of rat brain

1 reference

12 December 2020

Oxidant-induced hepatocyte injury from menadione is regulated by ERK and AP-1 signaling

1 reference

12 December 2020

Acute hyperammonemia in the young primate: physiologic and neuropathologic correlates.

1 reference

12 December 2020

Ammonia neurotoxicity and the mitochondrial permeability transition

1 reference

12 December 2020

Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices

1 reference

12 December 2020

The astrocytic ("peripheral-type") benzodiazepine receptor: role in the pathogenesis of portal-systemic encephalopathy

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12 December 2020

Intracellular pH rises and astrocytes swell after portacaval anastomosis in rats

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12 December 2020

NFkappaB in the mechanism of ammonia-induced astrocyte swelling in culture

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12 December 2020

The role of infection and inflammation in the pathogenesis of hepatic encephalopathy and cerebral edema in acute liver failure.

1 reference

12 December 2020

Downregulation of the 18-kDa translocator protein: effects on the ammonia-induced mitochondrial permeability transition and cell swelling in cultured astrocytes

1 reference

12 December 2020

Ascorbate inhibits edema in brain slices

1 reference

12 December 2020

The NF-kappa B and I kappa B proteins: new discoveries and insights

1 reference

12 December 2020

Benzodiazepine-induced protein tyrosine nitration in rat astrocytes

1 reference

12 December 2020

Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.

1 reference

12 December 2020

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

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12 December 2020

Role of glial cells in the regulation of the brain ion microenvironment

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12 December 2020

The role of astrocytes in hepatic encephalopathy

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12 December 2020

Differential inhibition by hyperammonemia of the electron transport chain enzymes in synaptosomes and non-synaptic mitochondria in ornithine transcarbamylase-deficient spf-mice: restoration by acetyl-L-carnitine.

1 reference

12 December 2020

Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes.

1 reference

12 December 2020

Role of the peripheral-type benzodiazepine receptor and the polypeptide diazepam binding inhibitor in steroidogenesis

1 reference

12 December 2020

Electron microscopy in human hepatic encephalopathy

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12 December 2020

Synthesis and release of neuroactive substances by glial cells

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12 December 2020

The mitochondrial permeability transition from in vitro artifact to disease target

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12 December 2020

Neurology and the liver

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12 December 2020

Hyperammonemia causes protein oxidation and enhanced proteasomal activity in response to mitochondria-mediated oxidative stress in rat primary astrocytes.

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12 December 2020

Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes

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12 December 2020

Ammonia induces the mitochondrial permeability transition in primary cultures of rat astrocytes

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12 December 2020

Astrocyte glutamate transport: review of properties, regulation, and physiological functions

1 reference

12 December 2020

The glial glutamate transporter in hyperammonemia and hepatic encephalopathy: relation to energy metabolism and glutamatergic neurotransmission.

1 reference

12 December 2020

Brain edema and the blood brain barrier in galactosamine-induced fulminant hepatic failure rats. An animal model for evaluation of liver support systems.

1 reference

12 December 2020

Glutamate-mediated astrocyte-neuron signalling

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12 December 2020

Endotoxemia produces coma and brain swelling in bile duct ligated rats

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12 December 2020

Ammonia selectively stimulates neutral amino acid transport across blood-brain barrier.

1 reference

12 December 2020

Partial pressure of ammonia versus ammonia in hepatic encephalopathy.

1 reference

12 December 2020

A light and electron microscopic study of experimental portal-systemic (ammonia) encephalopathy. Progression and reversal of the disorder

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12 December 2020

IkappaB kinase: beginning, not the end

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12 December 2020

Beta-DL-methylene-aspartate, an inhibitor of aspartate aminotransferase, potently inhibits L-glutamate uptake into astrocytes

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12 December 2020

Astrocytes induce blood–brain barrier properties in endothelial cells

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12 December 2020

The permeability transition pore as a mitochondrial calcium release channel: a critical appraisal

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12 December 2020

Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration

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12 December 2020

Pathophysiology of hepatic encephalopathy: a new look at ammonia

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12 December 2020

Phospholipase A2 and its role in brain tissue.

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12 December 2020

Suppression of ammonia-induced astrocyte swelling by cyclosporin A.

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12 December 2020

Effect of ammonium chloride on energy metabolism of astrocytes and C6-glioma cells in vitro.

1 reference

12 December 2020

Mitochondrial permeability transition and oxidative stress

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12 December 2020

Mitochondrial Benzodiazepine Receptors and the Regulation of Steroid Biosynthesis

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12 December 2020

Direct signaling from astrocytes to neurons in cultures of mammalian brain cells.

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12 December 2020

The effect of ammonium chloride on metabolism of primary neurons and neuroblastoma cells in vitro

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12 December 2020

The mitochondrial permeability transition in neurologic disease

1 reference

12 December 2020

Mechanisms of arachidonic acid induced glial swelling

1 reference

12 December 2020

Superoxide production and antioxidant enzymes in ammonia intoxication in rats.

1 reference

12 December 2020

Mitochondrial ROS-induced ROS release: an update and review

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12 December 2020

Astrocyte swelling and protein tyrosine nitration in hepatic encephalopathy

1 reference

12 December 2020

Increased brain concentrations of a neuroinhibitory steroid in human hepatic encephalopathy

1 reference

12 December 2020

Regional cerebral edema and chloride space in galactosamine-induced liver failure in rats.

1 reference

12 December 2020

GeneChip analysis shows altered mRNA expression of transcripts of neurotransmitter and signal transduction pathways in the cerebral cortex of portacaval shunted rats.

1 reference

12 December 2020

Effects of ammonia and beta-methylene-DL-aspartate on the oxidation of glucose and pyruvate by neurons and astrocytes in primary culture

1 reference

12 December 2020

Liver transplantation in Europe for patients with acute liver failure.

1 reference

12 December 2020

Blocking NMDA receptors prevents the oxidative stress induced by acute ammonia intoxication.

1 reference

12 December 2020

Effect of ammonium ions on synaptic transmission in the mammalian central nervous system

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12 December 2020

Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes.

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12 December 2020

Cytosolic phospholipase A2 (cPLA2) and lipid mediator release in the brain

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12 December 2020

Changes in the blood-brain barrier in hepatic coma after hepatectomy in the rat

1 reference

12 December 2020

The Release and Neosynthesis of Glutamic Acid Are Increased in Experimental Models of Hepatic Encephalopathy

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12 December 2020

Pyruvate decarboxylation in astrocytes and in neurons in primary cultures in the presence and the absence of ammonia.

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12 December 2020

Role for glia in synaptogenesis

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12 December 2020

Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase

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12 December 2020

Glutamate uptake by astrocytes is inhibited by reactive oxygen intermediates but not by other macrophage-derived molecules including cytokines, leukotrienes or platelet-activating factor

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12 December 2020

Astrocyte-mediated control of cerebral microcirculation

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12 December 2020

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12 December 2020

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

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12 December 2020

Hepatic encephalopathy: An update of pathophysiologic mechanisms

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12 December 2020

The hydroxyl radical scavengers dimethylsulfoxide and dimethylthiourea protect rats against thioacetamide-induced fulminant hepatic failure

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12 December 2020

Transport and Metabolism of Glutamate and Gaba in Neurons and Glial Cells

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12 December 2020

Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure.

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12 December 2020

DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria

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12 December 2020

Effects of ammonia on L-glutamate uptake in cultured astrocytes

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12 December 2020

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase

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12 December 2020

Pharmacological inhibitors of MAPK pathways.

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12 December 2020

Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier

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12 December 2020

The neurophysiology of glial cells

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12 December 2020

Electron microscopic evaluation of brain edema in rabbits with galactosamine-induced fulminant hepatic failure: ultrastructure and integrity of the blood-brain barrier.

1 reference

12 December 2020

Fulminant hepatic failure. Clinical features, etiology, epidemiology, and current management

1 reference

12 December 2020

Free radical-mediated neurotoxicity may be caused by inhibition of mitochondrial dehydrogenases in vitro and in vivo.

1 reference

12 December 2020

Increased blood-brain transfer in a rabbit model of acute liver failure

1 reference

12 December 2020

Brain edema in acute liver failure. A window to the pathogenesis of hepatic encephalopathy.

1 reference

12 December 2020

Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice

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12 December 2020

10.1007/S11011-008-9113-6

Identifiers

DOI

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19 August 2017

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PubMed ID

19104923