Crystal ball gazing: new therapeutic targets for hyperuricaemia and gout (Q37358460)

19 August 2017

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title

Crystal ball gazing: new therapeutic targets for hyperuricaemia and gout (English)

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19 August 2017

T Merriman

2

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Nicola Dalbeth

series ordinal

1

object named as

N Dalbeth

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19 August 2017

24 December 2008

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19 August 2017

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19 August 2017

48

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19 August 2017

3

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19 August 2017

222-226

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Mechanisms of inflammation in gout

19 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Febuxostat compared with allopurinol in patients with hyperuricemia and gout

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Sex-specific association of the putative fructose transporter SLC2A9 variants with uric acid levels is modified by BMI

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

SLC2A9 influences uric acid concentrations with pronounced sex-specific effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

SLC2A9--a fructose transporter identified as a novel uric acid transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the Third National Health and Nutrition Examination Survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Effect of oral fructose on urate production

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Relationship of the Trp64Arg polymorphism of the beta3-adrenoceptor gene to central adiposity and high blood pressure: interaction with age. Cross-sectional and longitudinal findings of the Olivetti Prospective Heart Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Lys418Asn polymorphism of the alpha2-adrenoceptor gene relates to serum uric acid levels but not to insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

The C677T mutation in the methylene tetrahydrofolate reductase gene increases serum uric acid in elderly men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Obesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Renal impairment and gout

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Polynesian women are also at risk for hyperuricaemia and gout because of a genetic defect in renal urate handling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Innate immunity: the virtues of a nonclonal system of recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Molecular identification of a danger signal that alerts the immune system to dying cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

The endogenous danger signal, crystalline uric acid, signals for enhanced antibody immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Uric acid promotes tumor immune rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Cutting edge: elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Cryopyrin activates the inflammasome in response to toxins and ATP

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Gout-associated uric acid crystals activate the NALP3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

A pilot study of IL-1 inhibition by anakinra in acute gout

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Enhanced osteoclastogenesis in patients with tophaceous gout: urate crystals promote osteoclast development through interactions with stromal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

Gout is associated with more comorbidities, poorer health-related quality of life and higher healthcare utilisation in US veterans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

The impact of gout on work absence and productivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEN460

10.1093/RHEUMATOLOGY/KEN460

21 January 2018

Identifiers

DOI

1 reference

19 August 2017

1 reference

PubMed ID

19109320