Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach (Q37359189)

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scientific article published on 25 June 2009

Language	Label	Description	Also known as
English	Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach	scientific article published on 25 June 2009

Statements

scholarly article

1 reference

Europe PubMed Central

19 August 2017

Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach (English)

1 reference

Europe PubMed Central

19 August 2017

0 references

object named as

Xiongwen Chen

2

0 references

Jeffery D. Molkentin

object named as

Jeffery D Molkentin

8

0 references

Steven R Houser

7

object named as

Steven R Houser

1 reference

Europe PubMed Central

19 August 2017

1

object named as

Qinghang Liu

1 reference

Europe PubMed Central

19 August 2017

author name string

Scott M Macdonnell

3

1 reference

Europe PubMed Central

19 August 2017

Evangelia G Kranias

4

1 reference

Europe PubMed Central

19 August 2017

John N Lorenz

5

1 reference

Europe PubMed Central

19 August 2017

Michael Leitges

6

1 reference

Europe PubMed Central

19 August 2017

publication date

25 June 2009

1 reference

Europe PubMed Central

19 August 2017

Circulation Research

1 reference

Europe PubMed Central

19 August 2017

105

1 reference

Europe PubMed Central

19 August 2017

2

1 reference

Europe PubMed Central

19 August 2017

194-200

1 reference

Europe PubMed Central

19 August 2017

Structural basis of protein kinase C isoform function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

PKC isozymes in chronic cardiac disease: possible therapeutic targets?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Adenovirus-delivered short hairpin RNA targeting PKCalpha improves contractile function in reconstituted heart tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Effect of ruboxistaurin in patients with diabetic macular edema: thirty-month results of the randomized PKC-DMES clinical trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

PKC-alpha regulates cardiac contractility and propensity toward heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Manipulating cardiac contractility in heart failure: data from mice and men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Protein Kinase Cα Negatively Regulates Systolic and Diastolic Function in Pathological Hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Phospholamban: a crucial regulator of cardiac contractility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Long-term expression of protein kinase C in adult mouse hearts improves postischemic recovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

Immunodeficiency in protein kinase cbeta-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

6 September 2017

PKCbeta modulates ischemia-reperfusion injury in the heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

2 September 2018

Ca2+ influx-induced sarcoplasmic reticulum Ca2+ overload causes mitochondrial-dependent apoptosis in ventricular myocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

2 September 2018

PKC-beta is not necessary for cardiac hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

2 September 2018

(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749656

2 September 2018

Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/19556521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C in the human heart: differential regulation of the isoforms in aortic stenosis or dilated cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19556521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of angiotensin-converting enzyme inhibition on protein kinase C and SR proteins in heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/19556521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/19556521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/19556521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKC translocation without changes in Galphaq and PLC-beta protein abundance in cardiac hypertrophy and failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/19556521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/19556521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19556521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased contractility and altered Ca(2+) transients of mouse heart myocytes conditionally expressing PKCbeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/19556521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19556521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19556521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of protein kinase C isoforms in heart failure due to myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19556521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modified hippocampal long-term potentiation in PKCγ-mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19556521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1161/CIRCRESAHA.109.195313

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

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