Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex (Q37374506)

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English	Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

20 August 2017

Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex (English)

1 reference

Europe PubMed Central

20 August 2017

author name string

R Wang

1

1 reference

Europe PubMed Central

20 August 2017

S J Shattil

2

1 reference

Europe PubMed Central

20 August 2017

D R Ambruso

3

1 reference

Europe PubMed Central

20 August 2017

P J Newman

4

1 reference

Europe PubMed Central

20 August 2017

language of work or name

0 references

publication date

1 November 1997

1 reference

Europe PubMed Central

20 August 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

20 August 2017

100

1 reference

Europe PubMed Central

20 August 2017

9

1 reference

Europe PubMed Central

20 August 2017

2393-2403

1 reference

Europe PubMed Central

20 August 2017

A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Glanzmann thrombasthenia. Cooperation between sequence variants in cis during splice site selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule

1 reference

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6 September 2017

Integrins: emerging paradigms of signal transduction

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6 September 2017

Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets

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6 September 2017

Signal transduction from the extracellular matrix

1 reference

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6 September 2017

Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling

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6 September 2017

An exon 28 mutation resulting in alternative splicing of the glycoprotein IIb transcript and Glanzmann's thrombasthenia.

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6 September 2017

"Inside-out" signal transduction inhibited by isolated integrin cytoplasmic domains.

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6 September 2017

Integrins and signal transduction pathways: the road taken

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6 September 2017

Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit association

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Amino acid 489 is encoded by a mutational "hot spot" on the beta 3 integrin chain: the CA/TU human platelet alloantigen system.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction

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6 September 2017

Integrin cytoplasmic domains mediate inside-out signal transduction

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

A single amino acid substitution flanking the fourth calcium binding domain of alpha IIb prevents maturation of the alpha IIb beta 3 integrin complex

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Identification of membrane proteins mediating the interaction of human platelets

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6 September 2017

Platelets have more than one binding site for von Willebrand factor

1 reference

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6 September 2017

Retention of the glycoprotein IIb-IIIa complex in the isolated platelet cytoskeleton. Effects of separable assembly of platelet pseudopodal and contractile cytoskeletons

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6 September 2017

A new technique for the assay of infectivity of human adenovirus 5 DNA

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6 September 2017

Integrins: a family of cell surface receptors

1 reference

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6 September 2017

Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage

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6 September 2017

The platelet membrane glycoprotein IIb-IIIa complex.

1 reference

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6 September 2017

Dynamic cytoskeleton-integrin associations induced by cell binding to immobilized fibronectin

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

The genomic organization of platelet glycoprotein IIIa

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6 September 2017

Integrins and other cell adhesion molecules

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6 September 2017

Control of intracellular pH and growth by fibronectin in capillary endothelial cells

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6 September 2017

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro

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6 September 2017

Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

The molecular genetic basis of Glanzmann thrombasthenia in the Iraqi-Jewish and Arab populations in Israel

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins

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6 September 2017

Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

A deletion in the gene for glycoprotein IIb associated with Glanzmann's thrombasthenia

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg----214Trp mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Integrins: versatility, modulation, and signaling in cell adhesion

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

An amino acid polymorphism within the RGD binding domain of platelet membrane glycoprotein IIIa is responsible for the formation of the Pena/Penb alloantigen system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Inside-out integrin signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Integrins as a primary signal transduction molecule regulating monocyte immediate-early gene induction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Regulation of fibronectin receptor distribution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Molecular basis for Glanzmann's thrombasthenia (GT) in a compound heterozygote with glycoprotein IIb gene: a proposal for the classification of GT based on the biosynthetic pathway of glycoprotein IIb-IIIa complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

Exposure of platelet fibrinogen receptors by ADP and epinephrine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

6 September 2017

The extracellular matrix as a cell survival factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

14 September 2017

Glanzmann thrombasthenia: new insights from an historical perspective.

1 reference

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14 September 2017

Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

14 September 2017

Glanzmann thrombasthenia due to a two amino acid deletion in the fourth calcium-binding domain of alpha IIb: demonstration of the importance of calcium-binding domains in the conformation of alpha IIb beta 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

28 September 2017

Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

28 September 2017

A fluorescent cellular adhesion assay using insect cell produced human VCAM1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

28 September 2017

Quantitation of membrane glycoprotein IIIa on intact human platelets using the monoclonal antibody, AP-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

28 September 2017

Inherited mutations within the calcium-binding sites of the integrin alpha IIb subunit (platelet glycoprotein IIb). Effects of the amino acid side chain and the amino acid position on cation binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

26 June 2018

The platelet cytoskeleton stabilizes the interaction between alphaIIbbeta3 and its ligand and induces selective movements of ligand-occupied integrin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

26 June 2018

Breaking the integrin hinge. A defined structural constraint regulates integrin signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

26 June 2018

Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

26 June 2018

Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

26 June 2018

Gel filtration. A new technique for separation of blood platelets from plasma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

26 June 2018

A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

26 June 2018

Organization of the gene for platelet glycoprotein IIb.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

26 June 2018

Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

26 June 2018

Regulation of Adhesion to ICAM-1 by the Cytoplasmic Domain of LFA-1 Integrin β Subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

26 June 2018

A spontaneous mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

26 June 2018

Analysis of GPIIb/IIIa receptor number by quantification of 7E3 binding to human platelets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

2 September 2018

A point mutation in the integrin beta 3 cytoplasmic domain (S752-->P) impairs bidirectional signaling through alpha IIb beta 3 (platelet glycoprotein IIb-IIIa).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

2 September 2018

On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP IIb-IIIa, pp60c-src, pp62c-yes, and the p21ras GTPase-activating protein with the membrane skeleton.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

2 September 2018

A monoclonal antibody to a membrane glycoprotein binds only to activated platelets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

2 September 2018

Integrin signaling: roles for the cytoplasmic tails of alpha IIb beta 3 in the tyrosine phosphorylation of pp125FAK

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

5 November 2018

Alpha v integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508438

5 November 2018

Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the cytoplasmic domain of the integrin beta 3 subunit. Differential effects on cell spreading, recruitment to adhesion plaques, endocytosis, and phagocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of platelet function through adhesion receptors. A dual role for glycoprotein IIb-IIIa (integrin alpha IIb beta 3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cytoplasmic domain of alphaIIb beta3. A ternary complex of the integrin alpha and beta subunits and a divalent cation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of fibronectin-coated beads with attached and spread fibroblasts. Binding, phagocytosis, and cytoskeletal reorganization

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A conformation-dependent epitope of human platelet glycoprotein IIIa

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct binding of the platelet integrin alphaIIbbeta3 (GPIIb-IIIa) to talin. Evidence that interaction is mediated through the cytoplasmic domains of both alphaIIb and beta3

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of cytoplasmic domain mutations on the agonist-stimulated ligand binding activity of the platelet integrin alphaIIbbeta3

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of two structurally and functionally distinct sites on human platelet membrane glycoprotein IIb-IIIa using monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of AP-2, a monoclonal antibody specific for the human platelet glycoprotein IIb-IIIa complex, with intact platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptides derived from a sequence within beta 3 integrin bind to platelet alpha IIb beta 3 (GPIIb-IIIa) and inhibit ligand binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/9351872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI119780

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

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