Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse (Q37376749)

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scientific article published on December 1997

Language	Label	Description	Also known as
English	Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse	scientific article published on December 1997

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scholarly article

1 reference

Europe PubMed Central

20 August 2017

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse (English)

1 reference

Europe PubMed Central

20 August 2017

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1 reference

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4

object named as

C R Kahn

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Europe PubMed Central

20 August 2017

author name string

N J Kerouz

1

1 reference

Europe PubMed Central

20 August 2017

D Hörsch

2

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Europe PubMed Central

20 August 2017

S Pons

3

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Europe PubMed Central

20 August 2017

language of work or name

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publication date

1 December 1997

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Europe PubMed Central

20 August 2017

Journal of Clinical Investigation

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Europe PubMed Central

20 August 2017

100

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Europe PubMed Central

20 August 2017

3164-3172

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Europe PubMed Central

20 August 2017

12

1 reference

Europe PubMed Central

20 August 2017

A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family

1 reference

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p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin

1 reference

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Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene

1 reference

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Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain

1 reference

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A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene

1 reference

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor

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The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling

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Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice

1 reference

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The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity

1 reference

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Regulation of human insulin receptor RNA splicing in vivo

1 reference

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Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats

1 reference

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Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus

1 reference

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Role of IRS-2 in insulin and cytokine signalling

1 reference

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4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice

1 reference

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6 September 2017

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508530

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Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

1 reference

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Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1 reference

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cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1 reference

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Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients

1 reference

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Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1 reference

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

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Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation

1 reference

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Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers

1 reference

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Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

1 reference

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Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance

1 reference

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Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit

1 reference

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Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew

1 reference

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Insulin Receptor Deficiency in Genetic and Acquired Obesity

1 reference

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Insulin action and the insulin signaling network

1 reference

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Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells

1 reference

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28 September 2017

Phosphatidylinositol 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508530

28 September 2017

Altered pattern of insulin receptor isotypes in skeletal muscle membranes of type 2 (non-insulin-dependent) diabetic subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508530

26 June 2018

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

1 reference

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Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells

1 reference

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Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase

1 reference

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Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2.

1 reference

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Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

1 reference

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The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508530

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Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508530

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508530

2 September 2018

Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/9399964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9399964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte growth factor-induced proliferation of primary hepatocytes is mediated by activation of phosphatidylinositol 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9399964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

1 reference

https://pubmed.ncbi.nlm.nih.gov/9399964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9399964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI119872

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

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