BRG1 and LKB1: tales of two tumor suppressor genes on chromosome 19p and lung cancer. (Q37379574)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19176640%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

review article

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title

BRG1 and LKB1: tales of two tumor suppressor genes on chromosome 19p and lung cancer (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19176640%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

author

Montse Sanchez-Cespedes

series ordinal

2

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20 January 2020

author name string

Salvador Rodriguez-Nieto

series ordinal

1

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20 January 2020

language of work or name

English

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publication date

28 January 2009

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20 January 2020

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20 January 2020

volume

30

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20 January 2020

issue

4

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20 January 2020

page(s)

547-554

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High-resolution genomic profiles of human lung cancer

20 January 2020

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Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

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Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene

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Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations.

21 January 2018

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LKB1 modulates lung cancer differentiation and metastasis

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Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients

21 January 2018

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Prevalence and specificity of LKB1 genetic alterations in lung cancers

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LKB1 mutation in large cell carcinoma of the lung

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Mutation analyses of 268 candidate genes in human tumor cell lines

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Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines

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A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

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Somatic mutations affect key pathways in lung adenocarcinoma

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Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

21 January 2018

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MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

21 January 2018

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Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome

21 January 2018

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Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

21 January 2018

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LKB1-dependent signaling pathways

21 January 2018

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The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death

21 January 2018

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Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest

21 January 2018

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Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

21 January 2018

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Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis

21 January 2018

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Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice

21 January 2018

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

21 January 2018

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

21 January 2018

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Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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The LKB1 tumor suppressor negatively regulates mTOR signaling

21 January 2018

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Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer.

21 January 2018

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Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

21 January 2018

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Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas

21 January 2018

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The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity

21 January 2018

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

21 January 2018

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LKB1 tumor suppressor protein: PARtaker in cell polarity

21 January 2018

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LKB1 and AMPK in cell polarity and division

21 January 2018

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LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis

21 January 2018

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LKB1 in endothelial cells is required for angiogenesis and TGFbeta-mediated vascular smooth muscle cell recruitment.

21 January 2018

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LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer.

21 January 2018

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The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression

21 January 2018

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Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

21 January 2018

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Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice

21 January 2018

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A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes

21 January 2018

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Characterization of mammary tumors from Brg1 heterozygous mice.

21 January 2018

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Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.

21 January 2018

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Lkb1 deficiency causes prostate neoplasia in the mouse

21 January 2018

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Targeted knockout of BRG1 potentiates lung cancer development

21 January 2018

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Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms

21 January 2018

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SWI/SNF chromatin remodeling and cancer

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Absence of hSNF5/INI1 mutation in human lung cancer.

21 January 2018

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The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

21 January 2018

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BRG1 controls the activity of the retinoblastoma protein via regulation of p21CIP1/WAF1/SDI.

21 January 2018

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Concomitant down-regulation of BRM and BRG1 in human tumor cell lines: differential effects on RB-mediated growth arrest vs CD44 expression.

21 January 2018

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Role for BRG1 in cell cycle control and tumor suppression

21 January 2018

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BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer

21 January 2018

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LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest

21 January 2018

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Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program

21 January 2018

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Human SWI-SNF component BRG1 represses transcription of the c-fos gene

21 January 2018

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c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function

21 January 2018

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Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex

21 January 2018

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A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex

21 January 2018

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Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes

21 January 2018

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Distinct steady-state nuclear receptor coregulator complexes exist in vivo

21 January 2018

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The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor

21 January 2018

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Use of a modified yeast one-hybrid screen to identify BAF60a interactions with the Vitamin D receptor heterodimer

21 January 2018

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Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells.

21 January 2018

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Regulation of CSF1 promoter by the SWI/SNF-like BAF complex

21 January 2018

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Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest

21 January 2018

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When the SWI/SNF complex remodels...the cell cycle

21 January 2018

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Transcription activator interactions with multiple SWI/SNF subunits.

21 January 2018

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The SWI/SNF complex--chromatin and cancer.

21 January 2018

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TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival

21 January 2018

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Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

21 January 2018

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Role of the mammalian SWI/SNF chromatin remodeling complex in the cellular response to UV damage

21 January 2018

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The BRG1- and hBRM-associated factor BAF57 induces apoptosis by stimulating expression of the cylindromatosis tumor suppressor gene

21 January 2018

1 reference

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BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2

21 January 2018

1 reference

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Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair

21 January 2018

1 reference

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Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers

21 January 2018

1 reference

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Role of alterations in the apoptotic machinery in sensitivity of cancer cells to treatment

21 January 2018

1 reference

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Genetic and epigenetic screening for gene alterations of the chromatin-remodeling factor, SMARCA4/BRG1, in lung tumors.

21 January 2018

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Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer.

21 January 2018

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Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancer

21 January 2018

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A conserved Swi2/Snf2 ATPase motif couples ATP hydrolysis to chromatin remodeling

21 January 2018

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Specific tandem GG to TT base substitutions induced by acetaldehyde are due to intra-strand crosslinks between adjacent guanine bases

21 January 2018

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Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network

21 January 2018

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BRG-1 is required for RB-mediated cell cycle arrest

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/CARCIN/BGP035

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19176640%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference