Knocking down barriers: advances in siRNA delivery (Q37380671)

20 August 2017

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title

Knocking down barriers: advances in siRNA delivery (English)

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20 August 2017

Robert S. Langer, Jr.

series ordinal

2

object named as

Robert Langer

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20 August 2017

Kathryn A Whitehead

1

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PubMed ID

19180106

20 August 2017

Daniel G Anderson

series ordinal

3

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20 August 2017

1 February 2009

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Nature Reviews Drug Discovery

20 August 2017

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20 August 2017

8

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20 August 2017

129-138

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20 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/nrd2742

20 August 2017

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Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

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Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone

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RNA interference targeting Fas protects mice from fulminant hepatitis

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Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

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Modulation of scratching behavior by silencing an endogenous cyclooxygenase-1 gene in the skin through the administration of siRNA

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An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

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31 March 2020

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Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV).

31 March 2020

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Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque

31 March 2020

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31 March 2020

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Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

31 March 2020

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31 March 2020

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31 March 2020

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Triggered release of siRNA from poly(ethylene glycol)-protected, pH-dependent liposomes

31 March 2020

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The in vitro kinetics of the interactions between PEG-ylated magnetic-fluid-loaded liposomes and macrophages.

31 March 2020

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Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes

31 March 2020

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Low-pH-sensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery

31 March 2020

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Biodistribution of phosphodiester and phosphorothioate siRNA.

31 March 2020

1 reference

Merging molecular imaging and RNA interference: early experience in live animals

31 March 2020

1 reference

RNAi-mediated gene silencing in non-human primates.

31 March 2020

1 reference

Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes

31 March 2020

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Transport of phosphorothioate oligonucleotides in kidney: implications for molecular therapy

31 March 2020

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Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

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Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target

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Retroviral vectors: new applications for an old tool

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31 March 2020

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31 March 2020

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31 March 2020

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Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference

31 March 2020

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A single siRNA suppresses fatal encephalitis induced by two different flaviviruses

31 March 2020

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Lipid-based nanoparticles for nucleic acid delivery

31 March 2020

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A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung

31 March 2020

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31 March 2020

1 reference

Cationic lipids enhance siRNA-mediated interferon response in mice.

31 March 2020

1 reference

Toxicogenomics of non-viral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity

31 March 2020

1 reference

Nonviral delivery of synthetic siRNAs in vivo

31 March 2020

1 reference

Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity

31 March 2020

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Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

31 March 2020

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Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection.

31 March 2020

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A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

31 March 2020

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Polymers for gene delivery across length scales.

31 March 2020

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Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis

31 March 2020

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The development and characterization of a glutathione-sensitive cross-linked polyethylenimine gene vector.

31 March 2020

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31 March 2020

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Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity.

31 March 2020

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Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat.

31 March 2020

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31 March 2020

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Gene transfer with modified polyethylenimines

31 March 2020

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Design and gene delivery activity of modified polyethylenimines.

31 March 2020

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Biophysical and structural characterization of polyethylenimine-mediated siRNA delivery in vitro.

31 March 2020

1 reference

Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung

31 March 2020

1 reference

A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes

31 March 2020

1 reference

Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

31 March 2020

1 reference

Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA.

31 March 2020

1 reference

Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging

31 March 2020

1 reference

Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles

31 March 2020

1 reference

Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes

31 March 2020

1 reference

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

31 March 2020

1 reference

Engineering mucosal RNA interference in vivo

31 March 2020

1 reference

Specific beta1-adrenergic receptor silencing with small interfering RNA lowers high blood pressure and improves cardiac function in myocardial ischemia

31 March 2020

1 reference

Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19180106

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The novel lipid delivery system of amphotericin B: drug profile and relevance to clinical practice.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19180106

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD2742

1 reference

20 August 2017

0 references

1 reference

PubMed ID

19180106