Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML (Q37381120)

20 August 2017

Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML (English)

1 reference

20 August 2017

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1 reference

4

Michael Andreeff

1 reference

20 August 2017

Kensuke Kojima

1

1 reference

20 August 2017

Masaya Shimanuki

series ordinal

2

1 reference

20 August 2017

Masato Shikami

series ordinal

3

1 reference

20 August 2017

Hideki Nakakuma

series ordinal

5

1 reference

20 August 2017

10 March 2009

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20 August 2017

1 reference

20 August 2017

100

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20 August 2017

6

1 reference

20 August 2017

1128-1136

1 reference

describes a project that uses

20 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2759356/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

A phase I pharmacokinetic and pharmacodynamic study of AT7519, a cyclin-dependent kinase inhibitor in patients with refractory solid tumors

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Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

6 September 2017

1 reference

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CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor

6 September 2017

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Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons

6 September 2017

1 reference

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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

6 September 2017

1 reference

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Targeting cell cycle kinases for cancer therapy

6 September 2017

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Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia

6 September 2017

1 reference

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Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1

6 September 2017

1 reference

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Cyclin-dependent kinase pathways as targets for cancer treatment

6 September 2017

1 reference

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Mammalian cyclin-dependent kinases

6 September 2017

1 reference

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Nongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma

6 September 2017

1 reference

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MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

6 September 2017

1 reference

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Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death

6 September 2017

1 reference

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Cdk1 and Cdk2 complexes (cyclin dependent kinases) in apoptosis: a role beyond the cell cycle

6 September 2017

1 reference

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A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint

6 September 2017

1 reference

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Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations

6 September 2017

1 reference

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

6 September 2017

1 reference

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The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.

6 September 2017

1 reference

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Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe.

6 September 2017

1 reference

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p21WAF1 prevents down-modulation of the apoptotic inhibitor protein c-IAP1 and inhibits leukemic apoptosis

6 September 2017

1 reference

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Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin

6 September 2017

1 reference

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Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.

6 September 2017

1 reference

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Synergistic cytotoxic activity of recombinant TRAIL plus the non-genotoxic activator of the p53 pathway nutlin-3 in acute myeloid leukemia cells

14 September 2017

1 reference

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Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis

14 September 2017

1 reference

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Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759356

Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759356

MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759356

Induction of apoptosis by flavopiridol unrelated to cell cycle arrest in germ cell tumour derived cell lines

14 September 2017

1 reference

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Negative regulation of bcl-2 expression by p53 in hematopoietic cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759356

p21(WAF1/CIP1) inhibits initiator caspase cleavage by TRAIL death receptor DR4.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759356

Cdk1 is sufficient to drive the mammalian cell cycle

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759356

Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia

26 June 2018

1 reference

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The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759356

Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma.

2 September 2018

1 reference

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Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL).

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759356

Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.

2 September 2018

1 reference

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Cdc2-cyclin E complexes regulate the G1/S phase transition

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759356

A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759356

Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759356

Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759356

Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759356

The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759356

The prognostic significance of p16(INK4a)/p14(ARF) locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759356

Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19385969

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1349-7006.2009.01150.X

1 reference

20 August 2017

1 reference

20 August 2017

PubMed publication ID

19385969

1 reference