The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML. (Q46544703)

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scientific article published on 12 June 2008

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English	The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML.	scientific article published on 12 June 2008

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scholarly article

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18548093

The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML. (English)

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18548093

author name string

K Kojima

1

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Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18548093

M Shimanuki

2

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Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18548093

M Shikami

3

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18548093

I J Samudio

4

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18548093

V Ruvolo

5

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18548093

P Corn

6

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18548093

N Hanaoka

7

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18548093

M Konopleva

8

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18548093

M Andreeff

9

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Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18548093

H Nakakuma

10

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23 December 2017

http://europepmc.org/abstract/MED/18548093

publication date

12 June 2008

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23 December 2017

http://europepmc.org/abstract/MED/18548093

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23 December 2017

http://europepmc.org/abstract/MED/18548093

22

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http://europepmc.org/abstract/MED/18548093

9

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23 December 2017

http://europepmc.org/abstract/MED/18548093

1728-1736

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23 December 2017

http://europepmc.org/abstract/MED/18548093

https://scigraph.springernature.com/pub.10.1038/leu.2008.158

0 references

PKB and the mitochondria: AKTing on apoptosis

1 reference

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mTOR, translation initiation and cancer

1 reference

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Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.

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Oncogenic PI3K and its role in cancer

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The activation of Akt/PKB signaling pathway and cell survival.

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Survival of acute myeloid leukemia cells requires PI3 kinase activation

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Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable

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Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia

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Constitutive phosphoinositide 3-kinase/Akt activation represents a favorable prognostic factor in de novo acute myelogenous leukemia patients.

1 reference

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p53 mutations in human cancers

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Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations

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Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

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Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.

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A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

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A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species.

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Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia

1 reference

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PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

1 reference

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21 January 2018

Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.158

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Phosphorylation of HDM2 by Akt.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.158

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Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1 reference

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The Akt-mTOR tango and its relevance to cancer

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TOR signaling in growth and metabolism

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Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax : Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity

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Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

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The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

1 reference

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The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change

1 reference

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21 January 2018

Substitutions of potentially phosphorylatable serine residues of Bax reveal how they may regulate its interaction with mitochondria

1 reference

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p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation

1 reference

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Regulation of protein synthesis by inducible wild-type p53 in human lung carcinoma cells

1 reference

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The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites

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Constitutive phosphorylation of the S6 ribosomal protein via mTOR and ERK signaling in the peripheral blasts of acute leukemia patients

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Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.

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Response and determinants of cancer cell susceptibility to PI3K inhibitors: combined targeting of PI3K and Mek1 as an effective anticancer strategy

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The impact of Epstein-Barr virus status on clinical outcome in diffuse large B-cell lymphoma

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PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways

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The prognostic significance of p16(INK4a)/p14(ARF) locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia

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Analysis of the p53 and MDM-2 gene in acute myeloid leukemia

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Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

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Identifiers

10.1038/LEU.2008.158

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18548093

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18548093

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