Examining polyglutamine peptide length: a connection between collapsed conformations and increased aggregation (Q37392379)

20 August 2017

Examining polyglutamine peptide length: a connection between collapsed conformations and increased aggregation (English)

1 reference

20 August 2017

Robert H Walters

1

1 reference

PMCID

2764006

20 August 2017

Regina M Murphy

series ordinal

2

1 reference

PMCID

2764006

20 August 2017

language of work or name

English

0 references

publication date

20 August 2009

1 reference

20 August 2017

15

1 reference

Journal of Molecular Biology

inferred from page(s)

published in

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20 August 2017

393

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20 August 2017

4

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20 August 2017

978-992

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Thermodynamics of beta-sheet formation in polyglutamine

20 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2764006

Single homopolypeptide chains collapse into mechanically rigid conformations

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2764006

Model discrimination and mechanistic interpretation of kinetic data in protein aggregation studies

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2764006

Kinetics of contact formation and end-to-end distance distributions of swollen disordered peptides

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2764006

Atomistic simulations of the effects of polyglutamine chain length and solvent quality on conformational equilibria and spontaneous homodimerization

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2764006

Polyglutamine neurodegeneration: protein misfolding revisited.

9 September 2017

1 reference

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Polyglutamine diseases: emerging concepts in pathogenesis and therapy

9 September 2017

1 reference

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Nucleocytoplasmic trafficking and transcription effects of huntingtin in Huntington's disease

9 September 2017

1 reference

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Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2764006

Normal-repeat-length polyglutamine peptides accelerate aggregation nucleation and cytotoxicity of expanded polyglutamine proteins

9 September 2017

1 reference

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End-to-end distance distributions and intrachain diffusion constants in unfolded polypeptide chains indicate intramolecular hydrogen bond formation

9 September 2017

1 reference

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Effects of denaturants on the dynamics of loop formation in polypeptides

9 September 2017

1 reference

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Failure of Energy Transfer between Identical Aromatic Molecules on Excitation at the Long Wave Edge of the Absorption Spectrum

9 September 2017

1 reference

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polyglutamine aggregation nucleation: thermodynamics of a highly unfavorable protein folding reaction

9 September 2017

1 reference

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Polyproline and the "spectroscopic ruler" revisited with single-molecule fluorescence.

9 September 2017

1 reference

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A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo

9 September 2017

1 reference

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Conformation of prion protein repeat peptides probed by FRET measurements and molecular dynamics simulations

9 September 2017

1 reference

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Polymer models of protein stability, folding, and interactions.

9 September 2017

1 reference

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Huntingtin aggregation and toxicity in Huntington's disease

9 September 2017

1 reference

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Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

9 September 2017

1 reference

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Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation

9 September 2017

1 reference

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Beyond the Qs in the polyglutamine diseases

9 September 2017

1 reference

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Solubilization and disaggregation of polyglutamine peptides

9 September 2017

1 reference

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Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease

9 September 2017

1 reference

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Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations

9 September 2017

1 reference

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Folding-unfolding transitions in single titin molecules characterized with laser tweezers.

9 September 2017

1 reference

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Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic

9 September 2017

1 reference

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Resonance energy transfer: methods and applications

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2764006

Random coil conformation for extended polyglutamine stretches in aqueous soluble monomeric peptides.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2764006

Effect of acid predissolution on fibril size and fibril flexibility of synthetic beta-amyloid peptide

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2764006

The intrinsic stiffness of polyglutamine peptides

26 June 2018

1 reference

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Sensitive biochemical aggregate detection reveals aggregation onset before symptom development in cellular and murine models of Huntington's disease

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2764006

Reconsidering the mechanism of polyglutamine peptide aggregation

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2764006

Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2764006

Effects of chain length on the aggregation of model polyglutamine peptides: molecular dynamics simulations

2 September 2018

1 reference

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Conformational distribution of a 14-residue peptide in solution: a fluorescence resonance energy transfer study.

2 September 2018

1 reference

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Kinetics of interior loop formation in semiflexible chains.

2 September 2018

1 reference

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Structural and functional analysis of ataxin-2 and ataxin-3.

2 September 2018

1 reference

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Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

2 September 2018

1 reference

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Neurodegeneration. A glutamine-rich trail leads to transcription factors

2 September 2018

1 reference

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Amyloid-like features of polyglutamine aggregates and their assembly kinetics

2 September 2018

1 reference

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Solution structure of polyglutamine tracts in GST-polyglutamine fusion proteins

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2764006

Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2764006

Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse.

2 September 2018

1 reference

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Pathogenic and Non-pathogenic Polyglutamine Tracts Have Similar Structural Properties: Towards a Length-dependent Toxicity Gradient

2 September 2018

1 reference

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Cooperative effects of cofilin (ADF) on actin structure suggest allosteric mechanism of cofilin function

3 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19699209

12 December 2020

inferred from PubMed ID database lookup

Interaction of alpha-dansylated peptide inhibitors with porcine pepsin: detection of complex formation by fluorescence energy transfer and chromatography and evidence for a two-step binding scheme

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19699209

12 December 2020

inferred from PubMed ID database lookup

A toxic monomeric conformer of the polyglutamine protein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19699209

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.JMB.2009.08.034

1 reference

20 August 2017

1 reference

20 August 2017

1 reference

PMCID

2764006