Molecular properties and CYP2D6 substrates: central nervous system therapeutics case study and pattern analysis of a substrate database (Q37415785)

20 August 2017

Molecular properties and CYP2D6 substrates: central nervous system therapeutics case study and pattern analysis of a substrate database (English)

1 reference

20 August 2017

0 references

Laura K Chico

1

1 reference

20 August 2017

Heather A Behanna

2

1 reference

20 August 2017

Wenhui Hu

3

1 reference

20 August 2017

Guifa Zhong

4

1 reference

20 August 2017

Saktimayee Mitra Roy

5

1 reference

20 August 2017

D Martin Watterson

6

1 reference

20 August 2017

6 August 2009

1 reference

Drug Metabolism and Disposition

20 August 2017

1 reference

20 August 2017

37

1 reference

20 August 2017

11

1 reference

20 August 2017

2204-2211

1 reference

20 August 2017

What are decision trees?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774985

DrugBank: a knowledgebase for drugs, drug actions and drug targets

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774985

The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774985

In silico predictions of blood-brain barrier penetration: considerations to "keep in mind".

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774985

Comparative molecular field analysis and QSAR on substrates binding to cytochrome p450 2D6.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774985

Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774985

Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774985

The influence of drug-like concepts on decision-making in medicinal chemistry

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774985

Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774985

Influence of Lipophilicity on the Interactions ofN-Alkyl-4-phenyl-1,2,3,6-tetrahydropyridines and Their Positively Charged N-Alkyl-4-phenylpyridinium Metabolites with Cytochrome P450 2D6

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774985

Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774985

Importance of amine pKa and distribution coefficient in the metabolism of fluorinated propranolol derivatives. Preparation, identification of metabolite regioisomers, and metabolism by CYP2D6.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774985

Characterization of dextromethorphan O- and N-demethylation catalyzed by highly purified recombinant human CYP2D6.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774985

Pharmacophoric fingerprint method (TOPP) for 3D-QSAR modeling: application to CYP2D6 metabolic stability

2 September 2018

1 reference

12 December 2020

Measurement of Michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach

1 reference

12 December 2020

The biotransformation of [14C]minaprine in man and five animals species

1 reference

12 December 2020

A refined substrate model for human cytochrome P450 2D6

1 reference

12 December 2020

1 reference

12 December 2020

Generation of a set of simple, interpretable ADMET rules of thumb

1 reference

12 December 2020

Identifiers

DOI

10.1124/DMD.109.028134

1 reference

20 August 2017

1 reference

20 August 2017

PubMed publication ID

19661215

1 reference