Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells. (Q37459500)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19435818%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

title

Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells (English)

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28 January 2020

1 reference

1 reference

5

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28 January 2020

author name string

Xiaoying Zhang

1

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28 January 2020

Ulka Shrikhande

2

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28 January 2020

Bethany M Alicie

3

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28 January 2020

Qing Zhou

4

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28 January 2020

language of work or name

1 reference

12 May 2009

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Molecular Cancer Research

28 January 2020

published in

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28 January 2020

volume

7

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28 January 2020

issue

5

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28 January 2020

page(s)

634-644

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The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells

28 January 2020

cites work

1 reference

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SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

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Nucleocytoplasmic trafficking of the Syk protein tyrosine kinase

23 August 2017

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Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo

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Syk tyrosine kinase participates in beta1-integrin signaling and inflammatory responses in airway epithelial cells

23 August 2017

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23 August 2017

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23 August 2017

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Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization

23 August 2017

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FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

23 August 2017

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Syk, a protein-tyrosine kinase, suppresses the cell motility and nuclear factor kappa B-mediated secretion of urokinase type plasminogen activator by inhibiting the phosphatidylinositol 3'-kinase activity in breast cancer cells

23 August 2017

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Cadherin and catenin alterations in human cancer

23 August 2017

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Syk expression and novel function in a wide variety of tissues

23 August 2017

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Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr

23 August 2017

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Cortactin: coupling membrane dynamics to cortical actin assembly

23 August 2017

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Vav proteins, adaptors and cell signaling.

23 August 2017

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The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression

23 August 2017

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Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization

23 August 2017

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The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells

23 August 2017

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Rho GTPases and their effector proteins

23 August 2017

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Tyrosine kinase SYK: essential functions for immunoreceptor signalling

23 August 2017

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Cadherins and their connections: adhesion junctions have broader functions.

23 August 2017

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Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase

23 August 2017

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Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323

23 August 2017

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Inactivation of the E-cadherin-mediated cell adhesion system in human cancers

23 August 2017

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Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3

23 August 2017

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beta-1 Integrins mediate tumour cell adhesion to quiescent endothelial cells in vitro.

23 August 2017

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Physical and functional association of cortactin with Syk in human leukemic cell line K562

23 August 2017

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Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine

23 August 2017

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Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia

23 August 2017

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Cortactin associates with N-cadherin adhesions and mediates intercellular adhesion strengthening in fibroblasts

23 August 2017

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Syk tyrosine kinase is linked to cell motility and progression in squamous cell carcinomas of the head and neck

23 August 2017

1 reference

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Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppression

14 September 2017

1 reference

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The non-receptor-associated tyrosine kinase Syk is a regulator of metastatic behavior in human melanoma cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

EphA2 induction of fibronectin creates a permissive microenvironment for malignant cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Progressive loss of Syk and abnormal proliferation in breast cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Beta1 integrin promotes but is not essential for metastasis of ras-myc transformed fibroblasts.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Rescue of the mutant phenotype by reexpression of full-length vinculin in null F9 cells; effects on cell locomotion by domain deleted vinculin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Cross-linking of integrins induces tyrosine phosphorylation of the proto-oncogene product Vav and the protein tyrosine kinase Syk in human factor-dependent myeloid cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. A possible signaling role for the Syk tyrosine kinase.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Expression and signaling activity of Wnt-5a/discoidin domain receptor-1 and Syk plays distinct but decisive roles in breast cancer patient survival.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Vinculin and alpha-catenin: shared and unique functions in adherens junctions

26 June 2018

1 reference

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Transformation of human breast epithelial cells by c-Ha-ras oncogene

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Clinical significance of nuclear expression of spleen tyrosine kinase (Syk) in gastric cancer

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Reactivation of SYK expression by inhibition of DNA methylation suppresses breast cancer cell invasiveness

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Syk is required for integrin signaling in neutrophils

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Hypermethylation leads to silencing of the SYK gene in human breast cancer.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Regulation of E-cadherin/Catenin association by tyrosine phosphorylation.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Tyrosine phosphorylation of cortactin associated with Syk accompanies thromboxane analogue-induced platelet shape change.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Anti-beta 1 integrin IgG inhibits pulmonary macrometastasis and the size of micrometastases from a murine mammary carcinoma.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migration

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788757

Expression of Syk in invasive breast cancer: correlation to proliferation and invasiveness

3 December 2018

1 reference

12 December 2020

Inhibition of signaling through the B cell antigen receptor by the protooncogene product, c-Cbl, requires Syk tyrosine 317 and the c-Cbl phosphotyrosine-binding domain

1 reference

12 December 2020

Reduced expression of the Syk gene is correlated with poor prognosis in human breast cancer

1 reference

12 December 2020

Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3

1 reference

12 December 2020

Signaling by adhesion in human neutrophils: activation of the p72syk tyrosine kinase and formation of protein complexes containing p72syk and Src family kinases in neutrophils spreading over fibrinogen

1 reference

12 December 2020

Attachment characteristics and involvement of integrins in adhesion of breast cancer cell lines to extracellular bone matrix components

1 reference

12 December 2020

10.1158/1541-7786.MCR-08-0371

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19435818%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19435818%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference