In vivo gene regulation using tetracycline-regulatable systems (Q37460085)

20 August 2017

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title

In vivo gene regulation using tetracycline-regulatable systems (English)

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20 August 2017

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5

Fabienne Rolling

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author name string

Knut Stieger

1

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20 August 2017

Brahim Belbellaa

2

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20 August 2017

Caroline Le Guiner

3

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20 August 2017

Philippe Moullier

4

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20 August 2017

Fabienne Rolling

5

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20 August 2017

language of work or name

English

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publication date

23 April 2009

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Advanced Drug Delivery Reviews

20 August 2017

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20 August 2017

61

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20 August 2017

7-8

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20 August 2017

527-541

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Targeting of Krüppel-associated box-containing zinc finger proteins to centromeric heterochromatin. Implication for the gene silencing mechanisms.

20 August 2017

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12 December 2020

Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors

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12 December 2020

Effective high-capacity gutless adenoviral vectors mediate transgene expression in human glioma cells.

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12 December 2020

Improved ecdysone receptor-based inducible gene regulation system

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12 December 2020

Regulation of gene expression in vivo following transduction by two separate rAAV vectors

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12 December 2020

Tetracycline transcriptional silencer tightly controls transgene expression after in vivo intramuscular electrotransfer: application to interleukin 10 therapy in experimental arthritis.

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A humanized system for pharmacologic control of gene expression

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12 December 2020

Transiently transfected and stably integrated HIV-1 LTR responds differentially to the silencing activity of the Krüppel-associated box (KRAB) transcriptional repressor domain

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12 December 2020

Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances

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12 December 2020

Switching transgene expression in the brain using an adenoviral tetracycline-regulatable system

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12 December 2020

Long-term and tight control of gene expression in mouse skeletal muscle by a new hybrid human transcription factor

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12 December 2020

Cell-type-specific and regulatable transgenesis in the adult brain: adenovirus-encoded combined transcriptional targeting and inducible transgene expression

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12 December 2020

Krüppel-associated box-mediated repression of RNA polymerase II promoters is influenced by the arrangement of basal promoter elements

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12 December 2020

Tetracycline-inducible viral interleukin-10 intraocular gene transfer, using adeno-associated virus in experimental autoimmune uveoretinitis.

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12 December 2020

Gene therapy progress and prospects: transcription regulatory systems.

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12 December 2020

The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression

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12 December 2020

A novel single tetracycline-regulative adenoviral vector for tumor-specific Bax gene expression and cell killing in vitro and in vivo.

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12 December 2020

Inducible long-term gene expression in brain with adeno-associated virus gene transfer

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12 December 2020

Regulatable gene expression systems for gene therapy

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12 December 2020

Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference

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12 December 2020

Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regions

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12 December 2020

A variety of RNA polymerases II and III-dependent promoter classes is repressed by factors containing the Krüppel-associated/finger preceding box of zinc finger proteins.

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12 December 2020

Efficient Tet-dependent expression of human factor IX in vivo by a new self-regulating lentiviral vector

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12 December 2020

Adeno-associated virus-mediated ILK gene silencing in the rat NAc core

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12 December 2020

Subantimicrobial dose doxycycline: a unique treatment for rosacea.

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12 December 2020

Optimal design of a single recombinant adeno-associated virus derived from serotypes 1 and 2 to achieve more tightly regulated transgene expression from nonhuman primate muscle

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12 December 2020

The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression.

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12 December 2020

A single lentivirus vector mediates doxycycline-regulated expression of transgenes in the brain

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12 December 2020

The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor

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12 December 2020

Gene transfer of a chimeric trans-activator is immunogenic and results in short-lived transgene expression

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12 December 2020

Mechanisms leading to sustained reversion of beta-thalassemia in mice by doxycycline-controlled Epo delivery from muscles

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12 December 2020

SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

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12 December 2020

The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins

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12 December 2020

KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.

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12 December 2020

Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum, using a tetracycline-dependent lentiviral vector

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12 December 2020

Sustained tetracycline-regulated transgene expression in vivo in rat retinal ganglion cells using a single type 2 adeno-associated viral vector

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12 December 2020

Controlled delivery of glial cell line-derived neurotrophic factor by a single tetracycline-inducible AAV vector.

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12 December 2020

Tumor inhibition by genomically integrated inducible RNAi-cassettes

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12 December 2020

Conformational changes of the Tet repressor induced by tetracycline trapping

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12 December 2020

Regulated and prolonged expression of mIFN(alpha) in immunocompetent mice mediated by a helper-dependent adenovirus vector

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12 December 2020

Tetracycline-reversible silencing of eukaryotic promoters

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12 December 2020

Immunization against the transgene but not the TetON switch reduces expression from gutless adenoviral vectors in the brain

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12 December 2020

Regulation of rod phototransduction machinery by ciliary neurotrophic factor

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12 December 2020

Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses.

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12 December 2020

A novel doxycycline inducible autoregulatory plasmid which displays "on"/"off" regulation suited to gene therapy applications

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12 December 2020

Liver-specific expression of interferon gamma following adenoviral gene transfer controls hepatitis B virus replication in mice.

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12 December 2020

Control of erythropoietin secretion by doxycycline or mifepristone in mice bearing polymer-encapsulated engineered cells

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12 December 2020

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice

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12 December 2020

Inducible nonviral gene expression in the treatment of osteochondral defects.

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12 December 2020

Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines

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12 December 2020

Tightly regulated gene expression in human hematopoietic stem cells after transduction with helper-dependent Ad5/35 vectors

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12 December 2020

Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts

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12 December 2020

Ocular immune privilege: therapeutic opportunities from an experiment of nature

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12 December 2020

Efficient control of gene expression in the hematopoietic system using a single Tet-on inducible lentiviral vector

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12 December 2020

Targeting of tetracycline-regulatable transgene expression specifically to neuronal and glial cell populations using adenoviral vectors

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12 December 2020

Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter

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12 December 2020

Tetracycline-regulated cardiac gene expression in vivo.

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12 December 2020

Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD

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12 December 2020

Retrovirus-mediated tk gene therapy of implanted human breast cancer in nude mice under the regulation of Tet-On

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12 December 2020

Controlled transgene expression by E1-E4-defective adenovirus vectors harbouring a "tet-on" switch system

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12 December 2020

Gene transfer into individual muscle fibers and conditional gene expression in living animals

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12 December 2020

Tight regulation from a single tet-off rAAV vector as demonstrated by flow cytometry and quantitative, real-time PCR.

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12 December 2020

Long-term inducible gene expression in the eye via adeno-associated virus gene transfer in nonhuman primates.

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12 December 2020

Update on rosacea and anti-inflammatory-dose doxycycline

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12 December 2020

Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons

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12 December 2020

Inducible shRNA expression for application in a prostate cancer mouse model

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12 December 2020

Stringent control of gene expression in vivo by using novel doxycycline-dependent trans-activators

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12 December 2020

Pharmacological regulation of protein expression from adeno-associated viral vectors in the eye.

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12 December 2020

Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: application to experimental arthritis

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12 December 2020

Tetracycline-regulated gene expression following direct gene transfer into mouse skeletal muscle

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12 December 2020

Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson's disease.

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12 December 2020

Exogenously regulated stem cell-mediated gene therapy for bone regeneration.

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12 December 2020

Construction of an rtTA2(s)-m2/tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primates

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12 December 2020

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

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12 December 2020

Doxycycline-regulated lentiviral vector system with a novel reverse transactivator rtTA2S-M2 shows a tight control of gene expression in vitro and in vivo

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12 December 2020

Regulated and Liver-Specific Tamarin Alpha Interferon Gene Delivery by a Helper-Dependent Adenoviral Vector

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12 December 2020

Immune responses against tetracycline-dependent transactivators affect long-term expression of mouse erythropoietin delivered by a helper-dependent adenoviral vector

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12 December 2020

Antibiotic options for treating community-acquired MRSA.

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12 December 2020

Immediate and long-term safety of recombinant adeno-associated virus injection into the nonhuman primate muscle

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12 December 2020

Genomic structure and chromosomal location of the rat gene encoding the zinc finger transcription factor Kid-1.

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12 December 2020

Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2(s)-M2 tetracycline transactivator and repressor system.

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12 December 2020

A versatile tool for conditional gene expression and knockdown

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12 December 2020

Overexpression of p27(Kip1) by doxycycline-regulated adenoviral vectors inhibits endothelial cell proliferation and migration and impairs angiogenesis.

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12 December 2020

Transient growth factor delivery sustains regenerated axons after spinal cord injury.

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12 December 2020

Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil

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12 December 2020

Coelectrotransfer to skeletal muscle of three plasmids coding for antiangiogenic factors and regulatory factors of the tetracycline-inducible system: tightly regulated expression, inhibition of transplanted tumor growth, and antimetastatic effect

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12 December 2020

Suicide gene therapy of human breast cancer in SCID mice model by the regulation of Tet-On

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12 December 2020

Tightly regulated long-term erythropoietin expression in vivo using tet-inducible recombinant adeno-associated viral vectors

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12 December 2020

Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease.

1 reference

12 December 2020

Tn10 tet operator mutations affecting Tet repressor recognition

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12 December 2020

Long-term doxycycline-regulated transgene expression in the retina of nonhuman primates following subretinal injection of recombinant AAV vectors

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12 December 2020

Transcriptional activation by tetracyclines in mammalian cells

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12 December 2020

Regulation of human factor IX expression using doxycycline-inducible gene expression system

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12 December 2020

Immune responses to gene product of inducible promoters

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12 December 2020

Recombinant AAV-mediated HSVtk gene transfer with direct intratumoral injections and Tet-On regulation for implanted human breast cancer

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12 December 2020

The use and safety of doxycycline hyclate and other second-generation tetracyclines.

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12 December 2020

In vitro- and in vivo-induced transgene expression in human embryonic stem cells and derivatives

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12 December 2020

Short-term BMP-2 expression is sufficient for in vivo osteochondral differentiation of mesenchymal stem cells

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12 December 2020

Modulation of neuronal survival and axonal growth in vivo by tetracycline-regulated neurotrophin expression.

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12 December 2020

Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential

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12 December 2020

Control of dopamine-secretion by Tet-Off system in an in vivo model of parkinsonian rat.

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12 December 2020

HLA-A*0201-restricted cytolytic responses to the rtTA transactivator dominant and cryptic epitopes compromise transgene expression induced by the tetracycline on system.

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12 December 2020

Krüppel-associated boxes are potent transcriptional repression domains

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12 December 2020

Highly efficient regulation of gene expression by tetracycline in a replication-defective herpes simplex viral vector

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12 December 2020

New complex Ad vectors incorporating both rtTA and tTS deliver tightly regulated transgene expression both in vitro and in vivo.

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12 December 2020

Enhancement of cell-specific transgene expression from a Tet-Off regulatory system using a transcriptional amplification strategy in the rat brain

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12 December 2020

KRAB-containing zinc-finger repressor proteins

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12 December 2020

Insulators coupled to a minimal bidirectional tet cassette for tight regulation of rAAV-mediated gene transfer in the mammalian brain

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12 December 2020

Molecular targets for retinal vascular diseases

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12 December 2020

Intrathecal coelectrotransfer of a tetracycline-inducible, three-plasmid-based system to achieve tightly regulated antinociceptive gene therapy for mononeuropathic rats

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12 December 2020

Oral administration of doxycycline allows tight control of transgene expression: a key step towards gene therapy of retinal diseases.

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12 December 2020

Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus

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12 December 2020

Tetracycline-inducible transgene expression mediated by a single AAV vector.

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12 December 2020

Manipulation of gene expression by an ecdysone-inducible gene switch in tumor xenografts

1 reference

12 December 2020

Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer.

1 reference

12 December 2020

Long-term doxycycline-regulated secretion of erythropoietin by encapsulated myoblasts

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12 December 2020

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

1 reference

12 December 2020

Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity

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12 December 2020

A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells

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12 December 2020

Recombinant AAV-mediated delivery of a tet-inducible reporter gene to the rat retina

1 reference

12 December 2020

Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector

1 reference

12 December 2020

Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system.

1 reference

12 December 2020

Regulated, electroporation-mediated delivery of pro-opiomelanocortin gene suppresses chronic constriction injury-induced neuropathic pain in rats

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12 December 2020

Lentiviral vectors: regulated gene expression

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12 December 2020

Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro

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12 December 2020

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

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12 December 2020

Second-generation tetracycline-regulatable promoter: repositioned tet operator elements optimize transactivator synergy while shorter minimal promoter offers tight basal leakiness

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12 December 2020

Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials

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12 December 2020

Conditional repression of the E2 transcription unit in E1-E3-deleted adenovirus vectors is correlated with a strong reduction in viral DNA replication and late gene expression in vitro

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12 December 2020

Antimalarial drugs in pregnancy: a review.

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12 December 2020

Control of erythropoietin delivery by doxycycline in mice after intramuscular injection of adeno-associated vector

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12 December 2020

A tetracycline-regulated adenoviral expression system for in vivo delivery of transgenes to lung and liver

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12 December 2020

Oral doxycycline versus intravenous ceftriaxone for European Lyme neuroborreliosis: a multicentre, non-inferiority, double-blind, randomised trial

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12 December 2020

4-Epidoxycycline: an alternative to doxycycline to control gene expression in conditional mouse models

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12 December 2020

10.1016/J.ADDR.2008.12.016

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DOI

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20 August 2017

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