Patents related to therapeutic activation of K(ATP) and K(2P) potassium channels for neuroprotection: ischemic/hypoxic/anoxic injury and general anesthetics (Q37481320)

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scientific article published on April 2009

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English	Patents related to therapeutic activation of K(ATP) and K(2P) potassium channels for neuroprotection: ischemic/hypoxic/anoxic injury and general anesthetics	scientific article published on April 2009

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scholarly article

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

Patents related to therapeutic activation of K(ATP) and K(2P) potassium channels for neuroprotection: ischemic/hypoxic/anoxic injury and general anesthetics (English)

1 reference

Europe PubMed Central

20 August 2017

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author name string

Susan I V Judge

1

1 reference

Europe PubMed Central

20 August 2017

Paul J Smith

2

1 reference

Europe PubMed Central

20 August 2017

language of work or name

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publication date

1 April 2009

1 reference

Europe PubMed Central

20 August 2017

Expert Opinion on Therapeutic Patents

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Europe PubMed Central

20 August 2017

19

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Europe PubMed Central

20 August 2017

4

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Europe PubMed Central

20 August 2017

433-460

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Europe PubMed Central

20 August 2017

Guide to Receptors and Channels (GRAC), 3rd edition

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Potassium channel blockers and openers as CNS neurologic therapeutic agents

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

ATP-regulated K+ channels in cardiac muscle

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Membrane current through adenosine-triphosphate-regulated potassium channels in guinea-pig ventricular cells

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Glucose dependent K+-channels in pancreatic beta-cells are regulated by intracellular ATP.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Adenosine-5'-triphosphate-sensitive ion channels in neonatal rat cultured central neurones.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive K+ channels.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

SUR, ABC proteins targeted by KATP channel openers.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

The sulphonylurea receptor may be an ATP-sensitive potassium channel.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Interaction of diazoxide, tolbutamide and ATP4- on nucleotide-dependent K+ channels in an insulin-secreting cell line.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Iptakalim protects against hypoxic brain injury through multiple pathways associated with ATP-sensitive potassium channels

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Pial microvascular responses to transient bilateral common carotid artery occlusion: effects of hypertonic glycerol

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Activation of ATP-sensitive potassium channels prevents the cleavage of cytosolic mu-calpain and abrogates the elevation of nuclear c-Fos and c-Jun expressions after hypoxic-ischemia in neonatal rat brain

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Hypothermic preconditioning increases survival of purkinje neurons in rat cerebellar slices after an in vitro simulated ischemia

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Diazoxide induces delayed pre‐conditioning in cultured rat cortical neurons

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Neuroprotection by ATP-dependent potassium channels in rat neocortical brain slices during hypoxia.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Increased hypoxic tolerance by chemical inhibition of oxidative phosphorylation: "chemical preconditioning".

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Mitochondrial ATP-sensitive K+ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

epsilonPKC phosphorylates the mitochondrial K(+) (ATP) channel during induction of ischemic preconditioning in the rat hippocampus

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Enhanced neuronal damage after ischemic insults in mice lacking Kir6.2-containing ATP-sensitive K+ channels

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Nicorandil attenuates NF-kappaB activation, adhesion molecule expression, and cytokine production in patients with coronary artery bypass surgery

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Remote ischemic preconditioning of the recipient reduces myocardial ischemia-reperfusion injury of the denervated donor heart via a Katp channel-dependent mechanism

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Sevoflurane-induced preconditioning of rat brain in vitro and the role of KATP channels

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Zinc inhibits glutamate release via activation of pre-synaptic K channels and reduces ischaemic damage in rat hippocampus

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Neuroprotective effect of KR-31378 via KATP channel opening against ischemic insult

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Intracellular pH and KATP channel activity in dorsal vagal neurons of juvenile rats in situ during metabolic disturbances

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Adenosine A(1) receptor antagonist and mitochondrial ATP-sensitive potassium channel blocker attenuate the tolerance to focal cerebral ischemia in rats

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

B-type natriuretic peptide limits infarct size in rat isolated hearts via KATP channel opening

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Role of transporters and ion channels in neuronal injury under hypoxia

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Regulation of extracellular glutamate levels in the long-term anoxic turtle striatum: coordinated activity of glutamate transporters, adenosine, K (ATP) (+) channels and GABA.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

KR-31378, a novel benzopyran analog, attenuates hypoxia-induced cell death via mitochondrial KATP channel and protein kinase C-epsilon in heart-derived H9c2 cells

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

ATP-independent anoxic activation of ATP-sensitive K+ channels in dorsal vagal neurons of juvenile mice in situ

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Distribution and phenotype of neurons containing the ATP-sensitive K+ channel in rat brain.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Evidence for mitochondrial K+ channels and their role in cardioprotection

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

K(ATP) channels and preconditioning: a re-examination of the role of mitochondrial K(ATP) channels and an overview of alternative mechanisms

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

KATP channel openers: structure-activity relationships and therapeutic potential

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Regulation by sulfanylurea receptor type 1 of a non-selective cation channel involved in cytotoxic edema of reactive astrocytes

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Drugs acting on SUR1 to treat CNS ischemia and trauma

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

ATP-sensitive potassium channels: novel potential roles in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Inhalational anesthetics as preconditioning agents in ischemic brain

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Anesthetic-mediated protection/preconditioning during cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Neuroprotection by KATP channels.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Adenosine and adenine nucleotides as regulators of cerebral blood flow: roles of acidosis, cell swelling, and KATP channels

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Glucose-sensing neurons of the hypothalamus

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Roles of KATP channels as metabolic sensors in acute metabolic changes

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Roles of ATP-sensitive K+ channels as metabolic sensors: studies of Kir6.x null mice

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

H2O2 signaling in the nigrostriatal dopamine pathway via ATP-sensitive potassium channels: issues and answers.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

K(ATP) channel pharmacogenomics: from bench to bedside

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

KATP channels as molecular sensors of cellular metabolism

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

KATP channel interaction with adenine nucleotides.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Protective role of neuronal KATP channels in brain hypoxia

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Inhibition of potassium channels in critical illness

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implications

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Human ether-a-go-go-related (HERG) gene and ATP-sensitive potassium channels as targets for adverse drug effects

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Physiological and pathophysiological roles of ATP-sensitive K+ channels

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

TASK, a human background K+ channel to sense external pH variations near physiological pH

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

YKC1 encodes the depolarization‐activated K+ channel in the plasma membrane of yeast

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

A pH-sensitive yeast outward rectifier K+ channel with two pore domains and novel gating properties.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

The structure, function and distribution of the mouse TWIK-1 K+ channel

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Changes in expression of some two-pore domain potassium channel genes (KCNK) in selected brain regions of developing mice.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Traumatic brain injury-induced acute gene expression changes in rat cerebral cortex identified by GeneChip analysis

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Altered neuronal expression of TASK1 and TASK3 potassium channels in rodent and human autoimmune CNS inflammation

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Polyunsaturated fatty acids are potent neuroprotectors

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Hypoxic depolarization of cerebellar granule neurons by specific inhibition of TASK-1

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Polymodal regulation of hTREK1 by pH, arachidonic acid, and hypoxia: physiological impact in acidosis and alkalosis

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Alterations in the expression of lipid and mechano-gated two-pore domain potassium channel genes in rat brain following chronic cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Enhanced expressions of arachidonic acid-sensitive tandem-pore domain potassium channels in rat experimental acute cerebral ischemia

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

The effects of hypoxia on the modulation of human TREK-1 potassium channels

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

The lipid-activated two-pore domain K+ channel TREK-1 is resistant to hypoxia: implication for ischaemic neuroprotection

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Alpha-linolenic acid and riluzole treatment confer cerebral protection and improve survival after focal brain ischemia

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Recombinant hTASK1 is an O(2)-sensitive K(+) channel

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

O2 sensing by recombinant TWIK-related halothane-inhibitable K+ channel-1 background K+ channels heterologously expressed in human embryonic kidney cells

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Structural requirements for O2 sensing by the human tandem-P domain channel, hTREK1

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Hydrogen peroxide selectively increases TREK-2 currents via myosin light chain kinases.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

TREK-1, a K+ channel involved in neuroprotection and general anesthesia

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Desensitization of mechano-gated K2P channels

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Identification of a region in the TASK3 two pore domain potassium channel that is critical for its blockade by methanandamide.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

The M1P1 loop of TASK3 K2P channels apposes the selectivity filter and influences channel function.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Control of cardiac rhythm by ORK1, a Drosophila two-pore domain potassium channel

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

A Ba2+-resistant, acid-sensitive K+ conductance in Na+-absorbing H441 human airway epithelial cells.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Physiology and pharmacology of two-pore domain potassium channels

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Two-pore domain K+ channels-molecular sensors

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

The neuronal background K2P channels: focus on TREK1

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Neuronal two-pore-domain potassium channels and their regulation by G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

K2P channels and their protein partners.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Properties and modulation of mammalian 2P domain K+ channels.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Recent advance and possible future in TREK-2: a two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

The TASK background K2P channels: chemo- and nutrient sensors.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Protective effects of TASK-3 (KCNK9) and related 2P K channels during cellular stress.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Two-pore domain potassium channels: new sites of local anesthetic action and toxicity

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

The TREK K2P channels and their role in general anaesthesia and neuroprotection

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Starring TREK-1: the next generation of vascular K+ channels.

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

The role of k+ channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Regulation of recombinant human brain tandem P domain K+ channels by hypoxia: a role for O2 in the control of neuronal excitability?

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Intracellular ATP directly blocks K+ channels in pancreatic B-cells

1 reference

https://api.crossref.org/works/10.1517%2F13543770902765151

21 January 2018

Identifiers

10.1517/13543770902765151

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

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