Cardionomics: a new integrative approach for screening cardiotoxicity of drug candidates (Q37481432)

20 August 2017

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title

Cardionomics: a new integrative approach for screening cardiotoxicity of drug candidates (English)

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20 August 2017

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Judith K Gwathmey

1

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20 August 2017

Katya Tsaioun

series ordinal

2

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20 August 2017

Roger J Hajjar

series ordinal

3

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20 August 2017

language of work or name

English

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publication date

1 June 2009

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Expert Opinion on Drug Metabolism & Toxicology

20 August 2017

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20 August 2017

5

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20 August 2017

6

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20 August 2017

647-660

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Developmental basis for electrophysiological heterogeneity in the ventricular and outflow tract myocardium as a substrate for life-threatening ventricular arrhythmias

20 August 2017

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Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group

21 January 2018

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Role of intracellular calcium handling in force-interval relationships of human ventricular myocardium

21 January 2018

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Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a

21 January 2018

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Mg-ATPase and Ca+ activated myosin AtPase activity in ventricular myofibrils from non-failing and diseased human hearts--effects of calcium sensitizing agents MCI-154, DPI 201-106, and caffeine

21 January 2018

1 reference

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Calcium-sensitizing inotropic agents in the treatment of heart failure: A critical view

21 January 2018

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Myofilament calcium regulation in human myocardium

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902932915

Chronic treatment with carvedilol improves ventricular function and reduces myocyte apoptosis in an animal model of heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902932915

Differential effect of DPI 201-106 on the sensitivity of the myofilaments to Ca2+ in intact and skinned trabeculae from control and myopathic human hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250902932915

Role of intracellular sodium in the regulation of intracellular calcium and contractility. Effects of DPI 201-106 on excitation-contraction coupling in human ventricular myocardium

21 January 2018

1 reference

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Fingerprint profile of alcohol-associated heart failure in human hearts

21 January 2018

1 reference

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Human cardiac-specific cDNA array for idiopathic dilated cardiomyopathy: sex-related differences

21 January 2018

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The significance of mitochondrial toxicity testing in drug development

21 January 2018

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Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells

21 January 2018

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Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

21 January 2018

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Multisite control of the Crabtree effect in ascites hepatoma cells.

21 January 2018

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Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants

21 January 2018

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Cell biology of atherosclerosis

21 January 2018

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Sarco/endoplasmic reticulum Ca2+-ATPase gene transfer reduces vascular smooth muscle cell proliferation and neointima formation in the rat.

21 January 2018

1 reference

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Alteration in temporal kinetics of Ca2+ signaling and control of growth and proliferation

21 January 2018

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Differential activation of transcription factors induced by Ca2+ response amplitude and duration

21 January 2018

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Phosphatidylinositol 3-Kinase and Calcium-Activated Transcription Pathways Are Required for VLDL-Induced Smooth Muscle Cell Proliferation

21 January 2018

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NFAT4 movement in native smooth muscle. A role for differential Ca(2+) signaling

21 January 2018

1 reference

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Constitutively active glycogen synthase kinase-3beta gene transfer sustains apoptosis, inhibits proliferation of vascular smooth muscle cells, and reduces neointima formation after balloon injury in rats

21 January 2018

1 reference

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A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization

21 January 2018

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Drug eluting coronary stents

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902932915

Cardiac excitation-contraction coupling

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902932915

Calcium fluxes involved in control of cardiac myocyte contraction

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902932915

Calcium cycling in heart failure: the arrhythmia connection

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902932915

Cellular basis of triggered arrhythmias in heart failure

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902932915

Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport

21 January 2018

1 reference

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Molecular basis of arrhythmias

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902932915

Molecular aspects of arrhythmias associated with cardiomyopathies

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902932915

Electrical remodeling in a canine model of ischemic cardiomyopathy

21 January 2018

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Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure

21 January 2018

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Novel therapeutic approaches for heart failure by normalizing calcium cycling

21 January 2018

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FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

21 January 2018

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Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.

21 January 2018

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Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902932915

Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression

21 January 2018

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Ryanodine receptor-targeted anti-arrhythmic therapy

21 January 2018

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Mapping arrhythmias in the failing heart: from Langendorff to patient

21 January 2018

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Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425250902932915

Action potential dynamics explain arrhythmic vulnerability in human heart failure: a clinical and modeling study implicating abnormal calcium handling

21 January 2018

1 reference

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Efficacy of Implantable Cardioverter–Defibrillators for the Prevention of Sudden Death in Patients with Hypertrophic Cardiomyopathy

21 January 2018

1 reference

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10.1517/17425250902932915

21 January 2018

Identifiers

DOI

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20 August 2017

1 reference