Facilitating replication under stress: an oncogenic function of MYC? (Q37492244)

20 August 2017

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title

Facilitating replication under stress: an oncogenic function of MYC? (English)

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20 August 2017

3

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20 August 2017

Steffi Herold

1

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PubMed ID

19461668

20 August 2017

Barbara Herkert

series ordinal

2

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PubMed ID

19461668

20 August 2017

language of work or name

English

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publication date

1 June 2009

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20 August 2017

Nature Reviews Cancer

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20 August 2017

9

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20 August 2017

6

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20 August 2017

441-444

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https://scigraph.springernature.com/pub.10.1038/nrc2640

20 August 2017

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Hepatic Stem-like Phenotype and Interplay of Wnt/β-Catenin and Myc Signaling in Aggressive Childhood Liver Cancer

31 March 2020

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Myc-driven murine prostate cancer shares molecular features with human prostate tumors

31 March 2020

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The MYC protein activates transcription of the alpha-prothymosin gene.

31 March 2020

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c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

31 March 2020

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

31 March 2020

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

31 March 2020

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Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts

31 March 2020

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Transient excess of MYC activity can elicit genomic instability and tumorigenesis

31 March 2020

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Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis

31 March 2020

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ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

31 March 2020

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The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo.

31 March 2020

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Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

31 March 2020

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Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase

31 March 2020

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Could MYC induction of mitochondrial biogenesis be linked to ROS production and genomic instability?

31 March 2020

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Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis

31 March 2020

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Myc's Mastery of Mitochondrial Mischief

31 March 2020

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MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species

31 March 2020

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E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination

31 March 2020

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HIF-dependent antitumorigenic effect of antioxidants in vivo

31 March 2020

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HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

31 March 2020

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HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma

31 March 2020

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Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes

31 March 2020

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A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

31 March 2020

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c-MYC protein is degraded in response to UV irradiation.

31 March 2020

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Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

31 March 2020

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Negative regulation of the mammalian UV response by Myc through association with Miz-1

31 March 2020

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Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

31 March 2020

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TopBP1 activates the ATR-ATRIP complex

31 March 2020

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Non-transcriptional control of DNA replication by c-Myc

31 March 2020

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ATR and ATM regulate the timing of DNA replication origin firing

31 March 2020

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miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression

31 March 2020

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Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes.

31 March 2020

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Global regulation of nucleotide biosynthetic genes by c-Myc

31 March 2020

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A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools

31 March 2020

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HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

31 March 2020

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Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

31 March 2020

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ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background

31 March 2020

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

31 March 2020

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

31 March 2020

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C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells

31 March 2020

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

31 March 2020

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ATR signaling can drive cells into senescence in the absence of DNA breaks

31 March 2020

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DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization.

31 March 2020

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Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19461668

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Myc-induced cyclin D2 genomic instability in murine B cell neoplasms.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19461668

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRC2640

1 reference

20 August 2017

1 reference

PubMed ID

19461668