TWEAK/Fn14 Axis: A Promising Target for the Treatment of Cardiovascular Diseases. (Q37494039)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24478772%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

TWEAK/Fn14 Axis: A Promising Target for the Treatment of Cardiovascular Diseases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24478772%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

main subject

cardiovascular disease

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24478772%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

author name string

Luis M Blanco-Colio

series ordinal

1

1 reference

20 August 2017

20 January 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24478772%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

published in

Frontiers in Immunology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24478772%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24478772%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

page(s)

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24478772%20AND%20SRC:MED&resulttype=core&format=json

Genetic deletion or TWEAK blocking antibody administration reduce atherosclerosis and enhance plaque stability in mice

6 March 2020

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Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice

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23 August 2017

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The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting

23 August 2017

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23 August 2017

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23 August 2017

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Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis

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Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin

23 August 2017

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TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules

23 August 2017

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23 August 2017

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HMGB1 expression and secretion are increased via TWEAK-Fn14 interaction in atherosclerotic plaques and cultured monocytes

23 August 2017

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6 September 2017

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6 September 2017

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B-cell stage and context-dependent requirements for survival signals from BAFF and the B-cell receptor.

6 September 2017

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Receptor activator of nuclear factor kappaB ligand is a novel inducer of tissue factor in macrophages

6 September 2017

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The CD163-expressing macrophages recognize and internalize TWEAK: potential consequences in atherosclerosis.

14 September 2017

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Cytokine cooperation in renal tubular cell injury: the role of TWEAK.

14 September 2017

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Tumor necrosis factor-like weak inducer of apoptosis inhibits skeletal myogenesis through sustained activation of nuclear factor-kappaB and degradation of MyoD protein.

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14 September 2017

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14 September 2017

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14 September 2017

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The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation

14 September 2017

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The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways

14 September 2017

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Tumor necrosis factor receptor superfamily 12 may destabilize atherosclerotic plaques by inducing matrix metalloproteinases

28 September 2017

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Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study

28 September 2017

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Soluble TWEAK is markedly upregulated in patients with ST-elevation myocardial infarction and related to an adverse short-term outcome.

28 September 2017

1 reference

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Tumor necrosis factor-related weak inducer of apoptosis augments matrix metalloproteinase 9 (MMP-9) production in skeletal muscle through the activation of nuclear factor-kappaB-inducing kinase and p38 mitogen-activated protein kinase: a potential r

26 June 2018

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The nuclear factor kappa-B signaling pathway participates in dysregulation of vascular smooth muscle cells in vitro and in human atherosclerosis

26 June 2018

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Phenotypic and genetic characterization of a unique B lymphocyte deficiency in strain A/WySnJ mice.

26 June 2018

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The relationships between serum sTWEAK, FGF-23 levels, and carotid atherosclerosis in renal transplant patients.

26 June 2018

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BAFF receptor deficiency reduces the development of atherosclerosis in mice--brief report.

2 September 2018

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B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions

2 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

Tumor necrosis factor-like weak inducer of apoptosis is a mitogen for liver progenitor cells

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

CD70-driven chronic immune activation is protective against atherosclerosis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 during cardiac remodelling in rats.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

Decreased soluble TWEAK levels predict an adverse prognosis in patients with chronic stable heart failure.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

The multi-functionality of CD40L and its receptor CD40 in atherosclerosis.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

FGF-inducible 14-kDa protein (Fn14) is regulated via the RhoA/ROCK kinase pathway in cardiomyocytes and mediates nuclear factor-kappaB activation by TWEAK.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

TWEAK/Fn14 pathway: a nonredundant role in intestinal damage in mice through a TWEAK/intestinal epithelial cell axis.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

Induction of the cytokine TWEAK and its receptor Fn14 in ischemic stroke

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

Serum levels of the atherosclerosis biomarker sTWEAK are decreased in type 2 diabetes and end-stage renal disease

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

Proinflammatory effects of tumour necrosis factor-like weak inducer of apoptosis (TWEAK) on human gingival fibroblasts.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

TWEAK-Fn14 pathway inhibition protects the integrity of the neurovascular unit during cerebral ischemia.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

Tumor necrosis factor-like weak inducer of apoptosis increases the permeability of the neurovascular unit through nuclear factor-kappa B pathway activation.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

Anti-TWEAK monoclonal antibodies reduce immune cell infiltration in the central nervous system and severity of experimental autoimmune encephalomyelitis.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

NF-kappaB activation and Fas ligand overexpression in blood and plaques of patients with carotid atherosclerosis: potential implication in plaque instability

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

A conduit system distributes chemokines and small blood-borne molecules through the splenic white pulp

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

Building up the blood-brain barrier.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

Requirement for CD154 in the progression of atherosclerosis.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

Impact of soluble TWEAK and CD163/TWEAK ratio on long-term cardiovascular mortality in patients with peripheral arterial disease

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

Soluble TWEAK plasma levels predict expansion of human abdominal aortic aneurysms

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

Differences in the predictive value of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in advanced ischemic and non-ischemic heart failure

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

TWEAK-Fn14 interaction enhances plasminogen activator inhibitor 1 and tissue factor expression in atherosclerotic plaques and in cultured vascular smooth muscle cells

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

Peripheral Artery Disease Is Associated With a High CD163/TWEAK Plasma Ratio

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3895871

Lower plasma soluble TWEAK concentration in patients with newly diagnosed hypertension

3 December 2018

1 reference

12 December 2020

Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- mice

1 reference

12 December 2020

Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization

1 reference

12 December 2020

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis-Induced Neurodegeneration

1 reference

12 December 2020

Soluble TWEAK is associated with atherosclerotic burden in patients with chronic kidney disease

1 reference

12 December 2020

Leukocyte CD40L deficiency affects the CD25(+) CD4 T cell population but does not affect atherosclerosis

1 reference

12 December 2020

Tumor Necrosis Factor–Like Weak Inducer of Apoptosis (TWEAK) Enhances Vascular and Renal Damage Induced by Hyperlipidemic Diet in ApoE-Knockout Mice

1 reference

12 December 2020

Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cells

1 reference

12 December 2020

Fn14-Fc fusion protein regulates atherosclerosis in ApoE-/- mice and inhibits macrophage lipid uptake in vitro

1 reference

12 December 2020

Soluble TWEAK and cardiovascular morbidity and mortality in chronic kidney disease patients.

1 reference

12 December 2020

Adventitial infiltrates associated with advanced atherosclerotic plaques: structural organization suggests generation of local humoral immune responses

1 reference

12 December 2020

Circulating sTWEAK improves the prediction of coronary artery disease

1 reference

12 December 2020

TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity

1 reference

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.3389/FIMMU.2014.00003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24478772%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24478772%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24478772%20AND%20SRC:MED&resulttype=core&format=json