Histone acetyltransferase inhibitors and preclinical studies (Q37497374)

20 August 2017

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title

Histone acetyltransferase inhibitors and preclinical studies (English)

1 reference

20 August 2017

Lucia Altucci

4

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Antonello Mai

object named as

Antonello Mai

series ordinal

3

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author name string

Fabio Manzo

series ordinal

1

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PubMed ID

19473103

20 August 2017

Francesco Paolo Tambaro

series ordinal

2

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PubMed ID

19473103

20 August 2017

language of work or name

English

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publication date

1 June 2009

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Expert Opinion on Therapeutic Patents

20 August 2017

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20 August 2017

19

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20 August 2017

761-774

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20 August 2017

6

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Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin.

20 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

The many HATs of transcription coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Anticancer activities of histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

A decade of histone acetylation: marking eukaryotic chromosomes with specific codes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Methylation of histone H3 mediates the association of the NuA3 histone acetyltransferase with chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Structure and ligand of a histone acetyltransferase bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Molecular recognition of histone H3 by the WD40 protein WDR5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Histone H4-K16 acetylation controls chromatin structure and protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

The silencing complex SAS-I links histone acetylation to the assembly of repressed chromatin by CAF-I and Asf1 in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Characterization of the yeast trimeric-SAS acetyltransferase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Acetylation: a regulatory modification to rival phosphorylation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Regulation of E2F1 activity by acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

E2F transcriptional activation requires TRRAP and GCN5 cofactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Implications of small molecule activators and inhibitors of histone acetyltransferases in chromatin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

(-)-Epigallocatechin-3-gallate suppresses osteoclast differentiation and ameliorates experimental arthritis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Epigenetics--an epicenter of gene regulation: histones and histone-modifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Specific inhibition of p300-HAT alters global gene expression and represses HIV replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Histone deacetylation in epigenetics: an attractive target for anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Histone Deacetylase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Exploring the connection unit in the HDAC inhibitor pharmacophore model: novel uracil-based hydroxamates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Epi-drugs to fight cancer: from chemistry to cancer treatment, the road ahead

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-gamma Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Role of curcumin in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Characterization of alkyl phenols in cashew (Anacardium occidentale) products and assay of their antioxidant capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha /IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated prot

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Inhibition of homodimerization of Toll-like receptor 4 by curcumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Cells lacking DNA topoisomerase II beta are resistant to genistein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Curcumin as a DNA topoisomerase II poison

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Curcumin impairs tumor suppressor p53 function in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Neutral sphingomyelinase activation in endothelial and glial cell death induced by amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902895727

10.1517/13543770902895727

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19473103