Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function (Q37498587)

20 August 2017

Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function (English)

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20 August 2017

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12

Elisabetta Dejana

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20 August 2017

1

Christine Jean

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20 August 2017

Xiao Lei Chen

2

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20 August 2017

Ju-Ock Nam

3

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20 August 2017

Isabelle Tancioni

4

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20 August 2017

Sean Uryu

5

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20 August 2017

Christine Lawson

6

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20 August 2017

Kristy K Ward

7

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20 August 2017

Colin T Walsh

8

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20 August 2017

Nichol L G Miller

9

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20 August 2017

Majid Ghassemian

10

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20 August 2017

Patric Turowski

11

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20 August 2017

Sara Weis

13

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20 August 2017

David A Cheresh

14

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20 August 2017

David D Schlaepfer

15

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20 August 2017

language of work or name

English

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publication date

1 January 2014

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20 August 2017

17

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based on heuristic

inferred from page(s)

published in

Journal of Cell Biology

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20 August 2017

204

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2

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20 August 2017

247-263

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describes a project that uses

20 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3897185/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Nuclear FAK: a new mode of gene regulation from cellular adhesions

23 August 2017

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Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression.

23 August 2017

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Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo

23 August 2017

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The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination

23 August 2017

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Molecular characterization of circulating tumor cells in patients with ovarian cancer improves their prognostic significance -- a study of the OVCAD consortium

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23 August 2017

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FAK promotes recruitment of talin to nascent adhesions to control cell motility

23 August 2017

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VEGF-induced vascular permeability is mediated by FAK.

23 August 2017

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Significance of vascular endothelial growth factor in growth and peritoneal dissemination of ovarian cancer

23 August 2017

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Circulating serologic and molecular biomarkers in malignant melanoma

23 August 2017

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Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment

23 August 2017

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Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability

23 August 2017

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Endothelial FAK is required for tumour angiogenesis

23 August 2017

1 reference

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Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development

23 August 2017

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Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.

23 August 2017

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Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

23 August 2017

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PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.

23 August 2017

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Antitumor activity of targeting SRC kinases in endothelial and myeloid cell compartments of the tumor microenvironment

23 August 2017

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Targeting focal adhesion kinase signaling in tumor growth and metastasis

23 August 2017

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23 August 2017

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Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling.

23 August 2017

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Molecular basis of metastasis.

23 August 2017

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The role of adherens junctions and VE-cadherin in the control of vascular permeability

23 August 2017

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Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.

23 August 2017

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Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271

23 August 2017

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Structural basis for the autoinhibition of focal adhesion kinase

23 August 2017

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Gene alterations identified by expression profiling in tumor-associated endothelial cells from invasive ovarian carcinoma

23 August 2017

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VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin

23 August 2017

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23 August 2017

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23 August 2017

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Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells

23 August 2017

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23 August 2017

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Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis

23 August 2017

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23 August 2017

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6 September 2017

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A clinically relevant, syngeneic model of spontaneous, highly metastatic B16 mouse melanoma

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897185

Conditional deletion of the focal adhesion kinase FAK alters remodeling of the blood-brain barrier in glioma

14 September 2017

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Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration

14 September 2017

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Polyethylenimine-complexed plasmid particles targeting focal adhesion kinase function as melanoma tumor therapeutics

14 September 2017

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Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model.

14 September 2017

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Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility.

14 September 2017

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Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors.

28 September 2017

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Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site.

2 September 2018

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Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897185

Focal adhesion kinase is expressed in the angiogenic blood vessels of malignant astrocytic tumors in vivo and promotes capillary tube formation of brain microvascular endothelial cells.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3897185

ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24446483

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.201307067

1 reference

20 August 2017

1 reference

20 August 2017

1 reference