MHC class I antigen presentation: learning from viral evasion strategies (Q37508563)

20 August 2017

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title

MHC class I antigen presentation: learning from viral evasion strategies (English)

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20 August 2017

Ted H Hansen

1

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20 August 2017

Marlene Bouvier

series ordinal

2

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20 August 2017

language of work or name

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1 July 2009

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Nature Reviews Immunology

20 August 2017

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20 August 2017

9

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20 August 2017

503-513

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20 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nri2575

20 August 2017

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cites work

The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex

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Molecular architecture of the TAP-associated MHC class I peptide-loading complex

21 January 2018

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Distinct functions of tapasin revealed by polymorphism in MHC class I peptide loading

21 January 2018

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The Ig-like domain of tapasin influences intermolecular interactions

21 January 2018

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Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading

21 January 2018

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A charged amino acid residue in the transmembrane/cytoplasmic region of tapasin influences MHC class I assembly and maturation.

21 January 2018

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Cowpox virus evades CTL recognition and inhibits the intracellular transport of MHC class I molecules

21 January 2018

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Bap29/31 influences the intracellular traffic of MHC class I molecules

21 January 2018

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Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules

21 January 2018

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Molecular machinations of the MHC-I peptide loading complex

21 January 2018

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Regulation of MHC class I assembly and peptide binding

31 March 2020

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The convergent roles of tapasin and HLA-DM in antigen presentation.

31 March 2020

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A comparison of viral immune escape strategies targeting the MHC class I assembly pathway

31 March 2020

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Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond

31 March 2020

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

31 March 2020

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The proteasome: paradigm of a self-compartmentalizing protease

31 March 2020

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Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1.

31 March 2020

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Inhibition of proteasomal degradation by the gly-Ala repeat of Epstein-Barr virus is influenced by the length of the repeat and the strength of the degradation signal

31 March 2020

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Gamma-herpesvirus latency requires T cell evasion during episome maintenance

31 March 2020

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In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma herpes virus

31 March 2020

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Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mimics Epstein-Barr virus EBNA1 immune evasion through central repeat domain effects on protein processing

31 March 2020

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Gly-Ala repeats induce position- and substrate-specific regulation of 26 S proteasome-dependent partial processing

31 March 2020

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Epstein-Barr virus oncogenesis and the ubiquitin-proteasome system.

31 March 2020

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Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex

31 March 2020

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Structure and mechanism of ABC transporters

31 March 2020

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A viral inhibitor of peptide transporters for antigen presentation

31 March 2020

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Herpes simplex virus turns off the TAP to evade host immunity

31 March 2020

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The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP

31 March 2020

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A viral ER-resident glycoprotein inactivates the MHC-encoded peptide transporter.

31 March 2020

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The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation.

31 March 2020

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Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP.

31 March 2020

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Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing

31 March 2020

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A CD8+ T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates

31 March 2020

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Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation

31 March 2020

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Cell lines transfected with the TAP inhibitor ICP47 allow testing peptide binding to a variety of HLA class I molecules

31 March 2020

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HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

31 March 2020

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Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47

31 March 2020

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Herpes simplex virus inhibitor ICP47 destabilizes the transporter associated with antigen processing (TAP) heterodimer

31 March 2020

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Allosteric crosstalk between peptide-binding, transport, and ATP hydrolysis of the ABC transporter TAP

31 March 2020

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The active site of ICP47, a herpes simplex virus-encoded inhibitor of the major histocompatibility complex (MHC)-encoded peptide transporter associated with antigen processing (TAP), maps to the NH2-terminal 35 residues

31 March 2020

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The active domain of the herpes simplex virus protein ICP47: a potent inhibitor of the transporter associated with antigen processing

31 March 2020

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The human cytomegalovirus gene product US6 inhibits ATP binding by TAP

31 March 2020

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Molecular mechanism and structural aspects of transporter associated with antigen processing inhibition by the cytomegalovirus protein US6.

31 March 2020

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Physical and functional interactions of the cytomegalovirus US6 glycoprotein with the transporter associated with antigen processing

31 March 2020

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Signaling of a varicelloviral factor across the endoplasmic reticulum membrane induces destruction of the peptide-loading complex and immune evasion

31 March 2020

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Peptides induce ATP hydrolysis at both subunits of the transporter associated with antigen processing

31 March 2020

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Functional dissection of the transmembrane domains of the transporter associated with antigen processing (TAP).

31 March 2020

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The first N-terminal transmembrane helix of each subunit of the antigenic peptide transporter TAP is essential for independent tapasin binding

31 March 2020

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Insights into MHC Class I Peptide Loading from the Structure of the Tapasin-ERp57 Thiol Oxidoreductase Heterodimer

31 March 2020

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Retention of empty MHC class I molecules by tapasin is essential to reconstitute antigen presentation in invertebrate cells

31 March 2020

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Analysis of interactions in a tapasin/class I complex provides a mechanism for peptide selection

31 March 2020

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A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes

31 March 2020

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Tapasin enhances MHC class I peptide presentation according to peptide half-life

31 March 2020

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Thiol oxidation and reduction in major histocompatibility complex class I-restricted antigen processing and presentation

31 March 2020

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Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP

31 March 2020

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Structural and functional dissection of human cytomegalovirus US3 in binding major histocompatibility complex class I molecules

31 March 2020

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Human cytomegalovirus inhibits tapasin-dependent peptide loading and optimization of the MHC class I peptide cargo for immune evasion

31 March 2020

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HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading.

31 March 2020

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Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes

31 March 2020

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Multiple residues in the transmembrane helix and connecting peptide of mouse tapasin stabilize the transporter associated with the antigen-processing TAP2 subunit

31 March 2020

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Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance

31 March 2020

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Retention of adenovirus E19 glycoprotein in the endoplasmic reticulum is essential to its ability to block antigen presentation

31 March 2020

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An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens

31 March 2020

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The E3/19K protein of adenovirus type 2 binds to the domains of histocompatibility antigens required for CTL recognition

31 March 2020

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Identification of class I MHC regions which bind to the adenovirus E3-19k protein

31 March 2020

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A short sequence in the COOH-terminus makes an adenovirus membrane glycoprotein a resident of the endoplasmic reticulum

31 March 2020

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The endoplasmic reticulum lumenal domain of the adenovirus type 2 E3-19K protein binds to peptide-filled and peptide-deficient HLA-A*1101 molecules

31 March 2020

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Allele- and locus-specific recognition of class I MHC molecules by the immunomodulatory E3-19K protein from adenovirus

31 March 2020

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Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP

31 March 2020

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Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2

31 March 2020

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Cowpox virus exploits the endoplasmic reticulum retention pathway to inhibit MHC class I transport to the cell surface

31 March 2020

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Definition and transfer of a serological epitope specific for peptide-empty forms of MHC class I.

31 March 2020

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Recognition of open conformers of classical MHC by chaperones and monoclonal antibodies

31 March 2020

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The optimization of peptide cargo bound to MHC class I molecules by the peptide-loading complex

31 March 2020

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An essential function of tapasin in quality control of HLA-G molecules

31 March 2020

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Intracellular transport of membrane glycoproteins: two closely related histocompatibility antigens differ in their rates of transit to the cell surface

31 March 2020

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Allele and locus-specific differences in cell surface expression and the association of HLA class I heavy chain with beta 2-microglobulin: differential effects of inhibition of glycosylation on class I subunit association

31 March 2020

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The majority of H2-M3 is retained intracellularly in a peptide-receptive state and traffics to the cell surface in the presence of N-formylated peptides

31 March 2020

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Differences among various class I molecules in competition for beta2m in vivo

31 March 2020

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One step at a time: endoplasmic reticulum-associated degradation

31 March 2020

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Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome

31 March 2020

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Viral immune evasion molecules attack the ER peptide-loading complex and exploit ER-associated degradation pathways

31 March 2020

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The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol

31 March 2020

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Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

31 March 2020

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Signal peptide peptidase is required for dislocation from the endoplasmic reticulum

31 March 2020

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Signal peptide-dependent inhibition of MHC class I heavy chain translation by rhesus cytomegalovirus

31 March 2020

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A membrane protein required for dislocation of misfolded proteins from the ER

31 March 2020

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A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

31 March 2020

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SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins

31 March 2020

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SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.

31 March 2020

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Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation

31 March 2020

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Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

31 March 2020

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MHC class I ubiquitination by a viral PHD/LAP finger protein.

31 March 2020

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K3-mediated evasion of CD8(+) T cells aids amplification of a latent gamma-herpesvirus.

31 March 2020

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Virus subversion of the MHC class I peptide-loading complex

31 March 2020

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Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3

31 March 2020

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The viral E3 ubiquitin ligase mK3 uses the Derlin/p97 endoplasmic reticulum-associated degradation pathway to mediate down-regulation of major histocompatibility complex class I proteins

31 March 2020

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Ubiquitination of MHC class I heavy chains is essential for dislocation by human cytomegalovirus-encoded US2 but not US11.

31 March 2020

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Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase

31 March 2020

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N-terminal ubiquitination: more protein substrates join in.

31 March 2020

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Requirements for the selective degradation of CD4 receptor molecules by the human immunodeficiency virus type 1 Vpu protein in the endoplasmic reticulum.

31 March 2020

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Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment.

31 March 2020

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Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor

31 March 2020

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The protein translocation channel binds proteasomes to the endoplasmic reticulum membrane

31 March 2020

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Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation

31 March 2020

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31 March 2020

ER stress and diseases.

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Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination

31 March 2020

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MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

31 March 2020

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Novel regulation of MHC class II function in B cells

31 March 2020

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Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses

31 March 2020

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Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis

31 March 2020

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Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins

31 March 2020

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The trafficking and regulation of membrane receptors by the RING-CH ubiquitin E3 ligases.

31 March 2020

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Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity

31 March 2020

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Functional organization of MIR2, a novel viral regulator of selective endocytosis

31 March 2020

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A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition

31 March 2020

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Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation

31 March 2020

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Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules

31 March 2020

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Kaposi sarcoma herpesvirus K5 removes CD31/PECAM from endothelial cells

31 March 2020

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Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

31 March 2020

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HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

31 March 2020

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Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

31 March 2020

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HIV-1 Nef-Induced Upregulation of DC-SIGN in Dendritic Cells Promotes Lymphocyte Clustering and Viral Spread

31 March 2020

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HIV-1 Nef impairs MHC class II antigen presentation and surface expression

31 March 2020

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Mechanism for down-regulation of CD28 by Nef.

31 March 2020

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Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner

31 March 2020

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Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein

31 March 2020

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HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail

31 March 2020

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A cytomegalovirus glycoprotein re-routes MHC class I complexes to lysosomes for degradation.

31 March 2020

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HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells

31 March 2020

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Early region 3 of adenovirus type 19 (subgroup D) encodes an HLA-binding protein distinct from that of subgroups B and C

31 March 2020

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12 December 2020

Slower processing, weaker beta 2-M association, and lower surface expression of H-2Ld are influenced by its amino terminus.

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12 December 2020

Cutting edge: adenovirus E19 has two mechanisms for affecting class I MHC expression.

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12 December 2020

Differential association between two human MHC class I antigens and an adenoviral glycoprotein

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12 December 2020

Reduced allorecognition of adenovirus-2 infected cells

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12 December 2020

Down-regulation of HLA antigens by the adenovirus type 2 E3/19K protein in a T-lymphoma cell line.

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12 December 2020

Requirements for the association of adenovirus type 2 E3/19K wild-type and mutant proteins with HLA antigens

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12 December 2020

Identification of amino acids within the MHC molecule important for the interaction with the adenovirus protein E3/19K.

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12 December 2020

Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP

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12 December 2020

Association of human class I MHC alleles with the adenovirus E3/19K protein

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12 December 2020

An extensive region of an MHC class I alpha 2 domain loop influences interaction with the assembly complex.

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12 December 2020

Inhibition of major histocompatibility complex class I antigen presentation in pig and primate cells by herpes simplex virus type 1 and 2 ICP47

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12 December 2020

Identifiers

DOI

10.1038/NRI2575

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Dimensions Publication ID

20 August 2017

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