Peptide deformylase--a promising therapeutic target for tuberculosis and antibacterial drug discovery (Q37521070)

20 August 2017

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title

Peptide deformylase--a promising therapeutic target for tuberculosis and antibacterial drug discovery (English)

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20 August 2017

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Anshika Sharma

1

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20 August 2017

Gopal K Khuller

series ordinal

2

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20 August 2017

Sadhna Sharma

series ordinal

3

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20 August 2017

language of work or name

English

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publication date

1 July 2009

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Expert Opinion on Therapeutic Targets

20 August 2017

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20 August 2017

13

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20 August 2017

7

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20 August 2017

753-765

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M. tuberculosis persistence, latency, and drug tolerance

20 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Molecular approaches to target discovery:--evaluating targets for anti-tuberculosis drug discovery programmes

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

Targeting the formation of the cell wall core of M. tuberculosis

21 January 2018

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Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target

21 January 2018

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Synthesis of methyl 5-S-alkyl-5-thio-D-arabinofuranosides and evaluation of their antimycobacterial activity

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

Synthesis and biological aspects of mycolic acids: an important target against Mycobacterium tuberculosis.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

Type II NADH: menaquinone oxidoreductase of Mycobacterium tuberculosis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

Phenothiazines as anti-multi-drug resistant tubercular agents.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

Drug targets in mycobacterial sulfur metabolism

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

Structural studies of shikimate 5-dehydrogenase from Mycobacterium tuberculosis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

Identification of gene targets against dormant phase Mycobacterium tuberculosis infections

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

Targeting iron acquisition by Mycobacterium tuberculosis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

Small molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

BB-3497, a peptide deformylase inhibitor, is active against Mycobacterium tuberculosis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

Novel approaches to developing new antibiotics for bacterial infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

A survey of polypeptide deformylase function throughout the eubacterial lineage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

N-formylmethionyl-sRNA as the initiator of protein synthesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903005590

A new human peptide deformylase inhibitable by actinonin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Characterization of a human peptide deformylase: implications for antibacterial drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Peptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

In vitro activity of a new antibiotic, NVP-PDF386 (VRC4887), against Chlamydia pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Therapeutic potential of peptide deformylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Bacterial Peptide deformylase inhibitors: a new class of antibacterial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

PDF inhibitors: an emerging class of antibacterial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

21 January 2018

N-FORMYL-METHIONYL-S-RNA

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Amidohydrolase activity of Escherichia coli extracts with formylated amino acids and dipeptides as substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Methionine aminopeptidase gene of Escherichia coli is essential for cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Processing of the initiation methionine from proteins: properties of the Escherichia coli methionine aminopeptidase and its gene structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Exit biology: battle for the nascent chain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Insights into the substrate specificity of plant peptide deformylase, an essential enzyme with potential for the development of novel biotechnology applications in agriculture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

The crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Peptide deformylase as an antibacterial target: a critical assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

YkrB is the main peptide deformylase in Bacillus subtilis, a eubacterium containing two functional peptide deformylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Characterization of peptide deformylase2 from B. cereus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Resistance of Streptococcus pneumoniae to deformylase inhibitors is due to mutations in defB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Origins of the different metal preferences of Escherichia coli peptide deformylase and Bacillus thermoproteolyticus thermolysin: a comparative quantum mechanical/molecular mechanical study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Enzymatic properties of Escherichia coli peptide deformylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Purification, characterization, and inhibition of peptide deformylase from Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Isolation and crystallization of functionally competent Escherichia coli peptide deformylase forms containing either iron or nickel in the active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Characterization of cobalt(II)-substituted peptide deformylase: function of the metal ion and the catalytic residue Glu-133.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Zinc is the metal cofactor of Borrelia burgdorferi peptide deformylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Solution structure of nickel-peptide deformylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Structure of peptide deformylase and identification of the substrate binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Crystal structure of the Escherichia coli peptide deformylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Iron center, substrate recognition and mechanism of peptide deformylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Energetic rationale for an unexpected and abrupt reversal of guanidinium chloride-induced unfolding of peptide deformylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Insight into the antibacterial drug design and architectural mechanism of peptide recognition from the E. faecium peptide deformylase structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Peptide deformylase of eukaryotic protists: a target for new antiparasitic agents?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Presence of N-formyl- and N-acetyl-methionine in the proteins of honey bee thorax

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Amino acid identities in the three redox center-carrying polypeptides of cytochrome bc1/b6f complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Rice peptide deformylase PDF1B is crucial for development of chloroplasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Type 3 peptide deformylases are required for oxidative phosphorylation in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Characterization of an eukaryotic peptide deformylase from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Deformylase as a novel antibacterial target.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Protease inhibitors: current status and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

α-Substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Structure--activity relationships of the peptide deformylase inhibitor BB-3497: modification of the P2' and P3' side chains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Prediction of the binding modes between BB-83698 and peptide deformylase from Bacillus stearothermophilus by docking and molecular dynamics simulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Theoretical study of the catalytic mechanism and metal-ion dependence of peptide deformylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

High-throughput identification of inhibitors of human mitochondrial peptide deformylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Discovery and refinement of a new structural class of potent peptide deformylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Antipneumococcal activity of LBM415, a new peptide deformylase inhibitor, compared with those of other agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Proteomic approach to understanding antibiotic action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Proteomic study of peptide deformylase inhibition in Streptococcus pneumoniae and Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Macrolactins O-R, glycosylated 24-membered lactones from Bacillus sp. AH159-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Design and synthesis of macrocyclic peptidyl hydroxamates as peptide deformylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Peptide deformylase inhibitors with activity against respiratory tract pathogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

In vitro activities of nine peptide deformylase inhibitors and five comparator agents against respiratory and skin pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Peptide deformylase inhibitors as potent antimycobacterial agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

The plastid-like organelle of apicomplexan parasites as drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Genes required for mycobacterial growth defined by high density mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Structure-function relationships within the peptide deformylase family. Evidence for a conserved architecture of the active site involving three conserved motifs and a metal ion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Structure analysis of peptide deformylases from Streptococcus pneumoniae, Staphylococcus aureus, Thermotoga maritima and Pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

The carboxy-terminal end of the peptide deformylase from Mycobacterium tuberculosis is indispensable for its enzymatic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Three consecutive arginines are important for the mycobacterial peptide deformylase enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Identification of regions involved in enzymatic stability of peptide deformylase of Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

Peptide deformylase inhibitors of Mycobacterium tuberculosis: synthesis, structural investigations, and biological results

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903005590

10.1517/14728220903005590

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference