Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates (Q37524238)

20 August 2017

Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates (English)

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20 August 2017

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Allegra CJ

1

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20 August 2017

Drake JC

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2

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20 August 2017

Jolivet J

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3

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20 August 2017

Chabner BA

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4

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20 August 2017

language of work or name

English

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publication date

1 August 1985

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Proceedings of the National Academy of Sciences of the United States of America

20 August 2017

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20 August 2017

82

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20 August 2017

15

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20 August 2017

4881-4885

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Characterization of the enzyme complex involving the folate-requiring enzymes of de novo purine biosynthesis

20 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390461

Enzymatic synthesis and function of folylpolyglutamates

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390461

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390461

Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390461

Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390461

Transport, binding, and polyglutamation of methotrexate in freshly isolated rat hepatocytes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390461

Methotrexate polyglutamate synthesis by cultured human breast cancer cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390461

The pharmacology and clinical use of methotrexate

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390461

Reversal of methotrexate binding to dihydrofolate reductase by dihydrofolate. Studies with pure enzyme and computer modeling using network thermodynamics

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390461

Synthesis and biological evaluation of poly-gamma-glutamyl derivatives of methotrexate.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390461

1 Measurement of molecular weights by electrophoresis on SDS-acrylamide gel

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390461

7,8-Dihydropteroyl oligo-γ-L-glutamates. Synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390461

A rapid assay for 5-amino-4-imidazolecarboxamide ribotide transformylase

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390461

Prolonged inhibition of DNA synthesis associated with the accumulation of methotrexate polyglutamates by cultured human cells

25 June 2018

1 reference

12 December 2020

Purification of a complex catalyzing folate cofactor synthesis and transformylation in de novo purine biosynthesis

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12 December 2020

Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate

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12 December 2020

On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver

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12 December 2020

Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo

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12 December 2020

Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro

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12 December 2020

A simple procedure for the synthesis of high specific activity tritiated (6S)-5-formyltetrahydrofolate

1 reference

12 December 2020

Enzymic preparation of the 1,L-diastereoisomer of tetrahydrofolic acid

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.82.15.4881

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20 August 2017

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20 August 2017

PubMed publication ID

3860829

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