A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease (Q37524888)

20 August 2017

A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease (English)

1 reference

20 August 2017

phase I clinical trial

0 references

sickle-cell disease

0 references

phase II clinical trial

0 references

author

Marvin E. Reid

3

1 reference

20 August 2017

4

Elliott P Vichinsky

1 reference

20 August 2017

Abdullah Kutlar

1

1 reference

20 August 2017

Kenneth Ataga

2

1 reference

20 August 2017

Lynne Neumayr

5

1 reference

20 August 2017

Loray Blair-Britt

6

1 reference

20 August 2017

Richard Labotka

7

1 reference

20 August 2017

Jonathan Glass

8

1 reference

20 August 2017

Jeffrey R Keefer

9

1 reference

20 August 2017

William A Wargin

10

1 reference

20 August 2017

Ronald Berenson

11

1 reference

20 August 2017

Susan P Perrine

12

1 reference

20 August 2017

7 August 2012

1 reference

American Journal of Hematology

20 August 2017

1 reference

20 August 2017

87

1 reference

20 August 2017

11

1 reference

20 August 2017

1017-1021

1 reference

Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG).

20 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Fetal hemoglobin in sickle cell anemia

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Evaluation of safety and pharmacokinetics of sodium 2,2 dimethylbutyrate, a novel short chain fatty acid derivative, in a phase 1, double-blind, placebo-controlled, single-dose, and repeat-dose studies in healthy volunteers.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

The inherited diseases of hemoglobin are an emerging global health burden

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Allogeneic hematopoietic stem-cell transplantation for sickle cell disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Discovering the genetics underlying foetal haemoglobin production in adults.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Erythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

BCL11A represses HBG transcription in K562 cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Fetal globin stimulant therapies in the beta-hemoglobinopathies: principles and current potential

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Sickle cell disease: new insights into pathophysiology and treatment.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Short-chain fatty acids induce gamma-globin gene expression by displacement of a HDAC3-NCoR repressor complex

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Enhancement of growth and survival and alterations in Bcl-family proteins in beta-thalassemic erythroid progenitors by novel short-chain fatty acid derivatives

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Drug metabolism and variability among patients in drug response

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Predicting clinical severity in sickle cell anaemia.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Pharmacologic modulation of fetal hemoglobin.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Structural bases of the inhibitory effects of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Levels of fetal hemoglobin necessary for treatment of sickle cell disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Participation of hemoglobins A and F in polymerization of sickle hemoglobin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Natural history of sickle cell anemia in Saudi Arabs. A study of 270 subjects

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

The effect of fetal hemoglobin on the survival characteristics of sickle cells

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Fetal hemoglobin in sickle cell anemia: determinants of response to hydroxyurea. Multicenter Study of Hydroxyurea.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Sickle cell anemia patients have low erythropoietin levels for their degree of anemia

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Hydroxyurea-induced augmentation of fetal hemoglobin production in patients with sickle cell anemia.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Induction of fetal hemoglobin synthesis in children with sickle cell anemia on low-dose oral sodium phenylbutyrate therapy

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Pathogenesis and treatment of sickle cell disease

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

F reticulocyte response in sickle cell anemia treated with recombinant human erythropoietin: a double-blind study.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Mortality in sickle cell disease. Life expectancy and risk factors for early death.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904792

Transcriptional silencing of fetal hemoglobin by BCL11A.

2 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FAJH.23306

Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FAJH.23306

Clinical trials in sickle cell disease: Adopting the combination chemotherapy paradigm

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FAJH.23306

Benign sickle-cell anaemia

21 January 2018

1 reference

12 December 2020

Alterations in protein-DNA interactions in the gamma-globin gene promoter in response to butyrate therapy

1 reference

12 December 2020

Fetal haemoglobin production and the sickle gene in the oases of Eastern Saudi Arabia

1 reference

12 December 2020

Analysis of hemoglobin F production in Saudi Arabian families with sickle cell anemia

1 reference

12 December 2020

An analysis of fetal hemoglobin variation in sickle cell disease: the relative contributions of the X-linked factor, beta-globin haplotypes, alpha-globin gene number, gender, and age

1 reference

12 December 2020

2-deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia

1 reference

12 December 2020

The significance of the paucity of sickle cells in newborn Negro infants

1 reference

12 December 2020

Pain in sickle cell disease. Rates and risk factors

1 reference

12 December 2020

A Short-Term Trial of Butyrate to Stimulate Fetal-Globin-Gene Expression in the β-Globin Disorders

1 reference

12 December 2020

https://api.fatcat.wiki/v0/release/kctscxl2bnbvld7xcrbvhgn57e

Identifiers

1 reference

30 July 2022

release_kctscxl2bnbvld7xcrbvhgn57e

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/kctscxl2bnbvld7xcrbvhgn57e

30 July 2022

https://api.fatcat.wiki/v0/release/kctscxl2bnbvld7xcrbvhgn57e

1 reference

30 July 2022

https://api.fatcat.wiki/v0/release/kctscxl2bnbvld7xcrbvhgn57e

PubMed publication ID

1 reference

30 July 2022