Emerging connection between centrosome and DNA repair machinery (Q37525988)

20 August 2017

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title

Emerging connection between centrosome and DNA repair machinery (English)

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20 August 2017

Mikio Shimada

1

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PubMed ID

19542690

20 August 2017

Kenshi Komatsu

series ordinal

2

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20 August 2017

20 June 2009

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Journal of Radiation Research

20 August 2017

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20 August 2017

50

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20 August 2017

4

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20 August 2017

295-301

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Genotoxic stress leads to centrosome amplification in breast cancer cell lines that have an inactive G1/S cell cycle checkpoint

20 August 2017

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Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity

21 January 2018

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Formation of the tetraploid intermediate is associated with the development of cells with more than four centrioles in the elastase-simian virus 40 tumor antigen transgenic mouse model of pancreatic cancer.

21 January 2018

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Genetic instabilities in human cancers

21 January 2018

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Centrosome amplification drives chromosomal instability in breast tumor development

21 January 2018

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Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

21 January 2018

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Cyclin-dependent kinase control of centrosome duplication

21 January 2018

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Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts

21 January 2018

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Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

21 January 2018

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Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication

21 January 2018

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Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

21 January 2018

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Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.

21 January 2018

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Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

21 January 2018

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Centrosomal localization of DNA damage checkpoint proteins

21 January 2018

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Mutations in the pericentrin (PCNT) gene cause primordial dwarfism

21 January 2018

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Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling

21 January 2018

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FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex

21 January 2018

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Centrosome function in normal and tumor cells

21 January 2018

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BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number

21 January 2018

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A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.

21 January 2018

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Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination

21 January 2018

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The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly

21 January 2018

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Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division

21 January 2018

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Positional cloning of the gene for Nijmegen breakage syndrome

21 January 2018

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Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

21 January 2018

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Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability

21 January 2018

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Nbs1 is required for ATR-dependent phosphorylation events

21 January 2018

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The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells

21 January 2018

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NBS1 and its functional role in the DNA damage response

21 January 2018

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NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

21 January 2018

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Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11.

21 January 2018

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PolyADP-ribosylation and cancer

21 January 2018

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Involvement of poly(ADP-Ribose) polymerase 1 and poly(ADP-Ribosyl)ation in regulation of centrosome function

21 January 2018

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Cohesin protein SMC1 is a centrosomal protein

21 January 2018

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Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.

21 January 2018

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Induction of centrosome amplification and chromosome instability in human bladder cancer cells by p53 mutation and cyclin E overexpression

21 January 2018

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Abnormal centrosome amplification in the absence of p53.

21 January 2018

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Chk2 activation dependence on Nbs1 after DNA damage

21 January 2018

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Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans

21 January 2018

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An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1269/JRR.09039

1 reference

20 August 2017

1 reference

PubMed ID

19542690