Sphingolipids as determinants of apoptosis and chemoresistance in the MCF-7 cell model system (Q37527497)

20 August 2017

1 reference

title

Sphingolipids as determinants of apoptosis and chemoresistance in the MCF-7 cell model system (English)

1 reference

20 August 2017

0 references

1 reference

William D Meacham

1

1 reference

20 August 2017

James W Antoon

2

1 reference

20 August 2017

Matthew E Burow

3

1 reference

20 August 2017

Amanda P Struckhoff

4

1 reference

20 August 2017

Barbara S Beckman

5

1 reference

20 August 2017

publication date

22 June 2009

1 reference

Experimental Biology and Medicine

20 August 2017

published in

1 reference

20 August 2017

volume

234

1 reference

20 August 2017

issue

11

1 reference

20 August 2017

page(s)

1253-1263

1 reference

Principles of bioactive lipid signalling: lessons from sphingolipids

20 August 2017

cites work

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Effects of sphingosine and other sphingolipids on protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Physiological and pathological actions of sphingosine 1-phosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Targeting sphingosine-1-phosphate for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Autocrine and paracrine roles of sphingosine-1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Sphingosine kinase transmits estrogen signaling in human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Tumor radiosensitivity and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Use of cellular and cytokine adjuvants in the immunotherapy of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Laser microdissection and microarray analysis of breast tumors reveal ER-alpha related genes and pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Identification of key processes underlying cancer phenotypes using biologic pathway analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

The Fas/Fas-ligand system: a mechanism for immune evasion in human breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Dexamethasone protection from TNF-alpha-induced cell death in MCF-7 cells requires NF-kappaB and is independent from AKT.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Anticlusterin treatment of breast cancer cells increases the sensitivities of chemotherapy and tamoxifen and counteracts the inhibitory action of dexamethasone on chemotherapy-induced cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Regulation of c-jun expression during hypoxic and low-glucose stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Can NF-kappaB be a target for novel and efficient anti-cancer agents?

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

NF-kappa B-mediated chemoresistance in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Activation of nuclear factor-kappa B is linked to resistance to neoadjuvant chemotherapy in breast cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Bax directly induces release of cytochrome c from isolated mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Functional estrogen receptors in the mitochondria of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

The protein kinase B/Akt signalling pathway in human malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Combining nanoliposomal ceramide with sorafenib synergistically inhibits melanoma and breast cancer cell survival to decrease tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Bioinformatics-based discovery and characterization of an AKT-selective inhibitor 9-chloro-2-methylellipticinium acetate (CMEP) in breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Tamoxifen-stimulated growth of breast cancer due to p21 loss

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

The oral mTOR inhibitor RAD001 (everolimus) in combination with letrozole in patients with advanced breast cancer: results of a phase I study with pharmacokinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug-resistant cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)- retinamide in neuroblastoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Taxol-induced ceramide generation and apoptosis in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Combined cytotoxic action of paclitaxel and ceramide against the human Tu138 head and neck squamous carcinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Novel ceramide analogs as potential chemotherapeutic agents in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Fumonisin B1 induces necrotic cell death in BV-2 cells and murine cultured astrocytes and is antiproliferative in BV-2 cells while N2A cells and primary cortical neurons are resistant

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Cardiovascular changes associated with intravenous administration of fumonisin B1 in horses

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Positively charged ceramide is a potent inducer of mitochondrial permeabilization.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Targeting ceramide metabolism--a strategy for overcoming drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

PI3K/Akt/mTOR pathway as a target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

Chemotherapy-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0902-MR-77

21 January 2018

Identifiers

DOI

10.3181/0902-MR-77

1 reference

20 August 2017

1 reference