Apoptosis and cancer: the genesis of a research field (Q37529250)

20 August 2017

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title

Apoptosis and cancer: the genesis of a research field (English)

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20 August 2017

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Thomas G Cotter

1

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20 August 2017

language of work or name

English

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publication date

1 July 2009

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20 August 2017

published in

Nature Reviews Cancer

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20 August 2017

volume

9

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20 August 2017

issue

7

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20 August 2017

page(s)

501-507

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

20 August 2017

cites work

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A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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CD95(APO-1/Fas)-mediated apoptosis in normal and malignant liver, colon, and hematopoietic cells

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Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

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Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma

31 March 2020

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Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

31 March 2020

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Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

31 March 2020

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Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

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IL3-dependent cells die by apoptosis on removal of their growth factor

31 March 2020

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Oncogenic potential of bcl-2 demonstrated by gene transfer.

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bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

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Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

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Caspase-activation pathways in apoptosis and immunity

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12 December 2020

Mitochondrial membrane permeabilization in cell death

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

31 March 2020

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MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

31 March 2020

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

31 March 2020

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

31 March 2020

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

31 March 2020

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Induction of apoptosis by the Bcl-2 homologue Bak

31 March 2020

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

31 March 2020

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BID: a novel BH3 domain-only death agonist

31 March 2020

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Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

31 March 2020

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Bcl-2 family proteins and cancer

31 March 2020

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miR-15 and miR-16 induce apoptosis by targeting BCL2

31 March 2020

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

31 March 2020

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

31 March 2020

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BID regulation by p53 contributes to chemosensitivity

31 March 2020

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PUMA induces the rapid apoptosis of colorectal cancer cells

31 March 2020

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PUMA, a novel proapoptotic gene, is induced by p53

31 March 2020

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Bad-deficient mice develop diffuse large B cell lymphoma

31 March 2020

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A role for proapoptotic BID in the DNA-damage response

31 March 2020

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

31 March 2020

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Apoptosis and expression of Bcl-2, Bcl-XL, and Bax in renal cell carcinomas.

31 March 2020

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Loss of heterozygosity at the bcl-2 gene locus and expression of bcl-2 in human gastric and colorectal carcinomas.

31 March 2020

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Predictive value of P53, BCL-2, and BAX in advanced head and neck carcinoma

31 March 2020

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Survivin, bcl-2, bax, and bcl-X gene expression in sentinel lymph nodes from melanoma patients.

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Survival of patients with metastatic breast carcinoma: importance of prognostic markers of the primary tumor.

31 March 2020

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Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis

31 March 2020

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A multivariate analysis of tumour biological factors predicting response to cytotoxic treatment in advanced breast cancer

31 March 2020

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Prognostic significance of apoptosis regulators in breast cancer.

31 March 2020

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Can expression of apoptosis genes, bcl-2 and bax, predict survival and responsiveness to chemotherapy in node-negative breast cancer patients?

31 March 2020

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Diagnosing and exploiting cancer's addiction to blocks in apoptosis

31 March 2020

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bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

31 March 2020

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BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

31 March 2020

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BCL-2 family antagonists for cancer therapy

31 March 2020

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Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas

31 March 2020

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Induction of apoptosis in fibroblasts by c-myc protein

31 March 2020

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Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

31 March 2020

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Myc potentiates apoptosis by stimulating Bax activity at the mitochondria

31 March 2020

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c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death

31 March 2020

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Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.

31 March 2020

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c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-XL

31 March 2020

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Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo

31 March 2020

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Reversible tumorigenesis by MYC in hematopoietic lineages

31 March 2020

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Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion

31 March 2020

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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

31 March 2020

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Transcriptional regulation by p53: one protein, many possibilities

31 March 2020

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Monoclonal antibody-mediated tumor regression by induction of apoptosis.

31 March 2020

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A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor

31 March 2020

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The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

31 March 2020

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Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family

31 March 2020

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Lethal effect of the anti-Fas antibody in mice

31 March 2020

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The TRAIL apoptotic pathway in cancer onset, progression and therapy

31 March 2020

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Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family

31 March 2020

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Identification and characterization of a new member of the TNF family that induces apoptosis

31 March 2020

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Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

31 March 2020

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Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

31 March 2020

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p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs

31 March 2020

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A role for CD95 ligand in preventing graft rejection

31 March 2020

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Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

31 March 2020

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Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells--a mechanism of immune evasion?

31 March 2020

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Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape

31 March 2020

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Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts.

31 March 2020

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

31 March 2020

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

31 March 2020

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Prognostic significance of p53, bcl-2 and Ki-67 in high risk superficial bladder cancer

31 March 2020

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12 December 2020

Expression of bcl-2 in small cell lung carcinoma cells.

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12 December 2020

Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis

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12 December 2020

Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma

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12 December 2020

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

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12 December 2020

BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma

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12 December 2020

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death.

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12 December 2020

Early work on the function of Bcl-2, an interview with David Vaux

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12 December 2020

Regulation of apoptosis in interleukin-3-dependent hemopoietic cells by interleukin-3 and calcium ionophores

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12 December 2020

Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification

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12 December 2020

bcl-w, a novel member of the bcl-2 family, promotes cell survival

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12 December 2020

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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12 December 2020

bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia

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12 December 2020

Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell.

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12 December 2020

Antisense-mediated inhibition of BCL2 protooncogene expression and leukemic cell growth and survival: comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides

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12 December 2020

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis

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12 December 2020

Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells

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12 December 2020

Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma

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12 December 2020

Identifiers

DOI

10.1038/NRC2663

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20 August 2017

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