LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism (Q37543834)

20 August 2017

1 reference

title

LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism (English)

1 reference

20 August 2017

4

Hans Clevers

1 reference

20 August 2017

Marnix Jansen

1

1 reference

PubMed ID

19584313

20 August 2017

Jean Paul Ten Klooster

series ordinal

2

1 reference

PubMed ID

19584313

20 August 2017

G Johan Offerhaus

series ordinal

3

1 reference

20 August 2017

1 July 2009

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20 August 2017

Physiological Reviews

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20 August 2017

89

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20 August 2017

3

1 reference

20 August 2017

777-798

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LKB1-dependent signaling pathways

20 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Unregulated smooth-muscle myosin in human intestinal neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

AMP-activated protein kinase in the heart: role during health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

The selectivity of protein kinase inhibitors: a further update

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

21 January 2018

The intestinal stem cell

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Identification of stem cells in small intestine and colon by marker gene Lgr5

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

The hamartoma-adenoma-carcinoma sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Emerging roles of pseudokinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Analysis of the LKB1-STRAD-MO25 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Genetic defects underlying Peutz-Jeghers syndrome (PJS) and exclusion of the polarity-associated MARK/Par1 gene family as potential PJS candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Peutz-Jeghers syndrome polyps are polyclonal with expanded progenitor cell compartment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

STRAD in Peutz-Jeghers syndrome and sporadic cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Characterization of an alternative splice variant of LKB1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

MAPs, MARKs and microtubule dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Metformin and reduced risk of cancer in diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Peutz-Jeghers syndrome and management recommendations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

The PAR proteins: fundamental players in animal cell polarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Frequency and spectrum of cancers in the Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Exonic STK11 deletions are not a rare cause of Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

De novo germline mutation in the serine-threonine kinase STK11/LKB1 gene associated with Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

LKB1 modulates lung cancer differentiation and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Enhanced stem cell survival in familial adenomatous polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Mammalian SAD kinases are required for neuronal polarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Mechanisms of asymmetric stem cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Asymmetric cell divisions promote stratification and differentiation of mammalian skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Energy-dependent regulation of cell structure by AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Prevalence and specificity of LKB1 genetic alterations in lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Peutz-Jeghers syndrome: clinicopathology and molecular alterations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

LKB1 and AMPK maintain epithelial cell polarity under energetic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

AMPK and PPARdelta agonists are exercise mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Colorectal cancer: mutations in a signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Lkb1 deficiency causes prostate neoplasia in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

The genetics of hereditary colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Calcineurin is required for translational control of protein synthesis in rat pancreatic acini

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Tenets of PTEN tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

LKB1 and lung cancer: more than the usual suspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

The LKB1 tumor suppressor negatively regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Histopathological mimicry in mucosal prolapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Mammalian AMP-activated protein kinase subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Lkb1 is required for TGFbeta-mediated myofibroblast differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Peutz-Jeghers syndrome: 78-year follow-up of the original family

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

BDNF instructs the kinase LKB1 to grow an axon

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Psychosocial impact of Peutz-Jeghers Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

The GC kinase Fray and Mo25 regulate Drosophila asymmetric divisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

AMP-activated protein kinase regulates the assembly of epithelial tight junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

ONCOGENESIS: Landscaping the Cancer Terrain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00026.2008

10.1152/PHYSREV.00026.2008

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19584313