Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome (Q37544962)

20 August 2017

Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome (English)

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20 August 2017

14

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5 June 2020

15

Antonio Tito Fojo

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5 June 2020

author name string

Ping-Yuan Wang

1

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5 June 2020

Jie Li

2

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5 June 2020

Farzana L Walcott

3

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5 June 2020

Ju-Gyeong Kang

4

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5 June 2020

Matthew F Starost

5

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5 June 2020

S Lalith Talagala

6

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Jie Zhuang

7

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5 June 2020

Ji-Hoon Park

8

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5 June 2020

Rebecca D Huffstutler

9

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5 June 2020

Christina M Bryla

10

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5 June 2020

Phuong L Mai

11

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5 June 2020

Michael Pollak

12

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Christina M Annunziata

13

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Paul M Hwang

16

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5 June 2020

language of work or name

English

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publication date

21 November 2016

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Journal of Clinical Investigation

20 August 2017

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5 June 2020

volume

127

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5 June 2020

issue

1

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5 June 2020

page(s)

132-136

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TP53 mutation, mitochondria and cancer

5 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199691

Targeting mitochondria metabolism for cancer therapy

23 August 2017

1 reference

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PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

23 August 2017

1 reference

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Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

23 August 2017

1 reference

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SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker

23 August 2017

1 reference

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Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity

23 August 2017

1 reference

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Metformin improves healthspan and lifespan in mice

23 August 2017

1 reference

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Increased oxidative metabolism in the Li-Fraumeni syndrome

23 August 2017

1 reference

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Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma

23 August 2017

1 reference

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Metformin prevents tobacco carcinogen--induced lung tumorigenesis

23 August 2017

1 reference

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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199691

Polo-like kinases mediate cell survival in mitochondrial dysfunction

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199691

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

23 August 2017

1 reference

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Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss

23 August 2017

1 reference

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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

23 August 2017

1 reference

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

23 August 2017

1 reference

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Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

23 August 2017

1 reference

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Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.

23 August 2017

1 reference

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Unravelling mechanisms of p53-mediated tumour suppression

6 September 2017

1 reference

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A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199691

Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199691

Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death

28 September 2017

1 reference

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Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?

25 June 2018

1 reference

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The mitochondrial complex I inhibitor rotenone induces endoplasmic reticulum stress and activation of GSK-3β in cultured rat retinal cells.

1 September 2018

1 reference

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Mutant p53 protein localized in the cytoplasm inhibits autophagy

1 September 2018

1 reference

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199691

1 September 2018

Identifiers

DOI

10.1172/JCI88668

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5 June 2020

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5 June 2020

1 reference