Alternative splicing of G protein-coupled receptors: physiology and pathophysiology (Q37560684)

21 August 2017

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title

Alternative splicing of G protein-coupled receptors: physiology and pathophysiology (English)

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G protein-coupled receptor

21 August 2017

main subject

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pathophysiology

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alternative mRNA splicing, via spliceosome

inferred from title

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Danijela Markovic

1

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21 August 2017

R A John Challiss

series ordinal

2

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21 August 2017

publication date

23 July 2009

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Cellular and Molecular Life Sciences

21 August 2017

published in

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21 August 2017

volume

66

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21 August 2017

issue

20

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21 August 2017

page(s)

3337-3352

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TGF-beta(1) regulation of human AT(1) receptor mRNA splice variants harboring exon 2.

21 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS00018-009-0093-4

Secretin receptors in normal and diseased human pancreas: marked reduction of receptor binding in ductal neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0093-4

Differential signaling of T cell generation of IL-4 by wild-type and short-deletion variant of type 2 G protein-coupled receptor for vasoactive intestinal peptide (VPAC2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0093-4

Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0093-4

Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery

21 January 2018

1 reference

12 December 2020

Focus on the splicing of secretin GPCRs transmembrane-domain 7.

1 reference

12 December 2020

Identification of the intracellular region of the leukotriene B4 receptor type 1 that is specifically involved in Gi activation

1 reference

12 December 2020

The expression of the pituitary growth hormone-releasing hormone receptor and its splice variants in normal and neoplastic human tissues

1 reference

12 December 2020

Agonist-independent activation of Src tyrosine kinase by a cholecystokinin-2 (CCK2) receptor splice variant

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12 December 2020

A novel GIP receptor splice variant influences GIP sensitivity of pancreatic beta-cells in obese mice

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12 December 2020

Postnatal expression of V2 vasopressin receptor splice variants in the rat cerebellum.

1 reference

12 December 2020

Neurokinin-1 (NK-1) receptor and brain-derived neurotrophic factor (BDNF) gene expression is differentially modulated in the rat spinal dorsal horn and hippocampus during inflammatory pain

1 reference

12 December 2020

Molecular biology of 5-HT receptors

1 reference

12 December 2020

Identification of a novel melanocortin 2 receptor splice variant in murine adipocytes: implications for post-transcriptional control of expression during adipogenesis.

1 reference

12 December 2020

Alternative splicing of the G protein-coupled receptor superfamily in human airway smooth muscle diversifies the complement of receptors

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12 December 2020

The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology.

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12 December 2020

Antagonists of growth hormone-releasing hormone arrest the growth of MDA-MB-468 estrogen-independent human breast cancers in nude mice

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12 December 2020

Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules

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12 December 2020

Sex steroid hormones change the differential distribution of the isoforms of the D2 dopamine receptor messenger RNA in the rat brain

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12 December 2020

G-protein-coupled receptors and melanoma

1 reference

12 December 2020

Identification and characterisation of a novel splice variant of the human CB1 receptor

1 reference

12 December 2020

Expression and function of NPSR1/GPRA in the lung before and after induction of asthma-like disease

1 reference

12 December 2020

A new LH receptor splice mutation responsible for male hypogonadism with subnormal sperm production in the propositus, and infertility with regular cycles in an affected sister

1 reference

12 December 2020

"Phenotypic" pharmacology: the influence of cellular environment on G protein-coupled receptor antagonist and inverse agonist pharmacology.

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12 December 2020

Aberrant RNA splicing and its functional consequences in cancer cells

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12 December 2020

Expression cloning of a human corticotropin-releasing-factor receptor

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12 December 2020

The human relaxin receptor (LGR7): expression in the fetal membranes and placenta

1 reference

12 December 2020

The dopamine D3 receptor interacts with itself and the truncated D3 splice variant d3nf: D3-D3nf interaction causes mislocalization of D3 receptors

1 reference

12 December 2020

A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channels

1 reference

12 December 2020

Prognostic and functional significance of thromboxane synthase gene overexpression in invasive bladder cancer

1 reference

12 December 2020

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

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12 December 2020

The Onset of Labor Alters Corticotropin-Releasing Hormone Type 1 Receptor Variant Expression in Human Myometrium: Putative Role of Interleukin-1β

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12 December 2020

Alternative splicing determines the post-endocytic sorting fate of G-protein-coupled receptors

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12 December 2020

A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes

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12 December 2020

Prostaglandins and leukotrienes: advances in eicosanoid biology

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12 December 2020

The Secretin GPCRs descended from the family of Adhesion GPCRs.

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12 December 2020

Inactivating mutations of LH and FSH receptors--from genotype to phenotype.

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12 December 2020

Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors

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12 December 2020

Wild-type and splice-variant secretin receptors in lung cancer: overexpression in carcinoid tumors and peritumoral lung tissue.

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12 December 2020

The spliceosome: design principles of a dynamic RNP machine

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12 December 2020

Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin

1 reference

12 December 2020

The expression of growth hormone-releasing hormone (GHRH) and its receptor splice variants in human breast cancer lines; the evaluation of signaling mechanisms in the stimulation of cell proliferation

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12 December 2020

The adhesion GPCRs: a unique family of G protein-coupled receptors with important roles in both central and peripheral tissues

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12 December 2020

Role of corticotropin-releasing hormone in onset of labour

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12 December 2020

A variant of the human corticotropin-releasing factor (CRF) receptor: cloning, expression and pharmacology

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12 December 2020

Lack of association between genetic variation in G-protein-coupled receptor for asthma susceptibility and childhood asthma and atopy

1 reference

12 December 2020

Impact of GPCRs in clinical medicine: monogenic diseases, genetic variants and drug targets

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12 December 2020

Activation of extracellular-regulated kinase pathways in ovarian granulosa cells by the novel growth factor type 1 follicle-stimulating hormone receptor. Role in hormone signaling and cell proliferation

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12 December 2020

A natural variant type II G protein-coupled receptor for vasoactive intestinal peptide with altered function

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12 December 2020

Antagonists of growth hormone-releasing hormone in oncology

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12 December 2020

A new mRNA splice variant coding for the human EP3-I receptor isoform.

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12 December 2020

Maternal corticotropin-releasing hormone is increased with impending preterm birth

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12 December 2020

Metabotropic glutamate receptors in acutely isolated hippocampal astrocytes: developmental changes of mGluR5 mRNA and functional expression.

1 reference

12 December 2020

Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers.

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12 December 2020

Characterization of GPRA, a novel G protein-coupled receptor related to asthma

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12 December 2020

Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression

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12 December 2020

The human placenta and fetal membranes express the corticotropin-releasing hormone receptor 1alpha (CRH-1alpha) and the CRH-C variant receptor

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12 December 2020

Expression of corticotropin-releasing hormone receptor type 1 and type 2 in human pregnant myometrium

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12 December 2020

A gene expression map for the euchromatic genome of Drosophila melanogaster.

1 reference

12 December 2020

Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth

1 reference

12 December 2020

Characterization of a common susceptibility locus for asthma-related traits

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12 December 2020

Activation of orphan receptors by the hormone relaxin

1 reference

12 December 2020

International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function

1 reference

12 December 2020

The PACAP receptor: generation by alternative splicing of functional diversity among G protein-coupled receptors in nerve cells

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12 December 2020

Immunomodulation by Tachykinin Neuropeptides

1 reference

12 December 2020

The delta e13 isoform of the calcitonin receptor forms a six-transmembrane domain receptor with dominant-negative effects on receptor surface expression and signaling.

1 reference

12 December 2020

Pharmacological characterization of human and murine neuropeptide s receptor variants

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12 December 2020

Detection of somatostatin receptor subtype 2 (SSTR2) in established tumors and tumor cell lines: evidence for SSTR2 heterogeneity

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12 December 2020

Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense?

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12 December 2020

Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.

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12 December 2020

Structural domains determining signalling characteristics of the CRH-receptor type 1 variant R1beta and response to PKC phosphorylation.

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12 December 2020

The histamine H3 receptor: from gene cloning to H3 receptor drugs

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12 December 2020

Alternative splicing of the D2 dopamine receptor messenger ribonucleic acid is modulated by activated sex steroid receptors in the MMQ prolactin cell line

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12 December 2020

Differential responses of corticotropin-releasing hormone receptor type 1 variants to protein kinase C phosphorylation

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12 December 2020

Identification of a tachykinin NK(2) receptor splice variant and its expression in human and rat tissues

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12 December 2020

Biochemical Characterization of Two Different Forms of the Substance P Receptor in Rat Submaxillary Gland

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12 December 2020

Update on human alpha1-adrenoceptor subtype signaling and genomic organization.

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12 December 2020

Spliceosome-mediated RNA trans-splicing

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12 December 2020

Identification of novel splice variants of Adhesion G protein-coupled receptors

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12 December 2020

Headless splice variant acting as dominant negative calcitonin receptor

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12 December 2020

The alternatively spliced deltae13 transcript of the rabbit calcitonin receptor dimerizes with the C1a isoform and inhibits its surface expression

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12 December 2020

Splice variants of G protein-coupled receptors

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12 December 2020

Multiple D2 dopamine receptors produced by alternative RNA splicing

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12 December 2020

Intracellular mechanisms regulating corticotropin-releasing hormone receptor-2beta endocytosis and interaction with extracellularly regulated kinase 1/2 and p38 mitogen-activated protein kinase signaling cascades.

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12 December 2020

VPAC and PAC receptors: From ligands to function

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12 December 2020

Developmental regulation of metabotropic glutamate receptor 1 splice variants in olfactory bulb mitral cells.

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12 December 2020

Multiple opiate receptors: déjà vu all over again

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12 December 2020

Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors

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12 December 2020

Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor

1 reference

12 December 2020

Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta

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12 December 2020

Alternative isoform regulation in human tissue transcriptomes

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12 December 2020

Neurokinin 1 receptor isoforms and the control of innate immunity

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12 December 2020

Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor

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12 December 2020

An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing

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12 December 2020

Prominence of the dopamine D2 short isoform in dopaminergic pathways

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12 December 2020

Trans-acting factors regulate the expression of CD44 splice variants.

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12 December 2020

Somatostatin receptors

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12 December 2020

Structural diversity of G protein-coupled receptors and significance for drug discovery

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12 December 2020

Alternative splicing unmasks dendritic and axonal targeting signals in metabotropic glutamate receptor 1

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12 December 2020

The connection between splicing and cancer.

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12 December 2020

Stimulation of proliferation of MCF-7 breast cancer cells by a transfected splice variant of growth hormone-releasing hormone receptor.

1 reference

12 December 2020

Alternative splicing: an important mechanism for myometrial gene regulation that can be manipulated to target specific genes associated with preterm labour

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12 December 2020

Luteinizing hormone receptor ectodomain splice variant misroutes the full-length receptor into a subcompartment of the endoplasmic reticulum.

1 reference

12 December 2020

A soluble mouse brain splice variant of type 2alpha corticotropin-releasing factor (CRF) receptor binds ligands and modulates their activity

1 reference

12 December 2020

Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function.

1 reference

12 December 2020

Internalization of the TXA2 receptor alpha and beta isoforms. Role of the differentially spliced cooh terminus in agonist-promoted receptor internalization

1 reference

12 December 2020

Isoforms of the rat calcitonin receptor: consequences for ligand binding and signal transduction

1 reference

12 December 2020

Human angiotensin II type 1 receptor isoforms encoded by messenger RNA splice variants are functionally distinct

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12 December 2020

Why are human G-protein-coupled receptors predominantly intronless?

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12 December 2020

Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor

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12 December 2020

Two novel transcripts for human endothelin B receptor produced by RNA editing/alternative splicing from a single gene

1 reference

12 December 2020

A misspliced form of the cholecystokinin-B/gastrin receptor in pancreatic carcinoma: role of reduced sellular U2AF35 and a suboptimal 3'-splicing site leading to retention of the fourth intron

1 reference

12 December 2020

Novel down-regulatory mechanism of the surface expression of the vasopressin V2 receptor by an alternative splice receptor variant.

1 reference

12 December 2020

Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.

1 reference

12 December 2020

Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor

1 reference

12 December 2020

Homer: a protein that selectively binds metabotropic glutamate receptors

1 reference

12 December 2020

Growth hormone-releasing hormone: an autocrine growth factor for small cell lung carcinoma.

1 reference

12 December 2020

Discovery of naturally occurring splice variants of the rat histamine H3 receptor that act as dominant-negative isoforms

1 reference

12 December 2020

Developmental expression and subcellular localization of wallaby gonadotropin-releasing hormone receptor and its splice variants.

1 reference

12 December 2020

Human corticotropin-releasing hormone receptor: differences in subtype expression between pregnant and nonpregnant myometria.

1 reference

12 December 2020

Differential signal transduction by five splice variants of the PACAP receptor

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12 December 2020

Prostanoid receptors: subtypes and signaling

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12 December 2020

A novel corticotropin-releasing factor receptor splice variant exhibits dominant negative activity: a putative link to stress-induced heart disease

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12 December 2020

Putative alternative trans-splicing of leukocyte adhesion-GPCR pre-mRNAs generates functional chimeric receptors

1 reference

12 December 2020

7TM receptors: the splicing on the cake

1 reference

12 December 2020

Differential expression of 5'-UTR splice variants of the adenosine A2A receptor gene in human granulocytes: identification, characterization, and functional impact on activation

1 reference

12 December 2020

Cloning, expression, and functional characterization of relaxin receptor (leucine-rich repeat-containing g protein-coupled receptor 7) splice variants from human fetal membranes

1 reference

12 December 2020

Tissue-specific transcription start sites and alternative splicing of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor gene: a new PTH/PTHrP receptor splice variant that lacks the signal peptide

1 reference

12 December 2020

Inhibition of growth and metastases of MDA-MB-435 human estrogen-independent breast cancers by an antagonist of growth hormone-releasing hormone

1 reference

12 December 2020

Structural determinants critical for localization and signaling within the seventh transmembrane domain of the type 1 corticotropin releasing hormone receptor: lessons from the receptor variant R1d.

1 reference

12 December 2020

Placental corticotrophin-releasing hormone and its receptors in human pregnancy and labour: still a scientific enigma

1 reference

12 December 2020

Alternative splicing in the nervous system: an emerging source of diversity and regulation

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12 December 2020

Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation

1 reference

12 December 2020

Expression of growth hormone-releasing hormone receptor splice variant 1 in primary human melanomas

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12 December 2020

Splicing in disease: disruption of the splicing code and the decoding machinery

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12 December 2020

Metabotropic glutamate receptors.

1 reference

12 December 2020

CRF1 receptor splicing in epidermal keratinocytes: potential biological role and environmental regulations

1 reference

12 December 2020

Novel role of thromboxane receptors beta isoform in bladder cancer pathogenesis.

1 reference

12 December 2020

Detection of full-length and truncated neurokinin-1 receptor mRNA expression in human brain regions

1 reference

12 December 2020

Pharmacological evaluation of alpha and beta human tachykinin NK(2) receptor splice variants expressed in CHO cells

1 reference

12 December 2020

A role for SC35 and hnRNPA1 in the determination of amyloid precursor protein isoforms

1 reference

12 December 2020

Initial sequencing and analysis of the human genome

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12 December 2020

Behavioral sensitization, alternative splicing, and d3 dopamine receptor-mediated inhibitory function

1 reference

12 December 2020

Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas

1 reference

12 December 2020

10.1007/S00018-009-0093-4

Identifiers

DOI

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21 August 2017

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