Advances in the pulmonary delivery of poorly water-soluble drugs: influence of solubilization on pharmacokinetic properties (Q37565681)

21 August 2017

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title

Advances in the pulmonary delivery of poorly water-soluble drugs: influence of solubilization on pharmacokinetic properties (English)

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21 August 2017

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Justin A Tolman

1

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PubMed ID

19640248

21 August 2017

Robert O Williams

series ordinal

2

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PubMed ID

19640248

21 August 2017

language of work or name

English

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publication date

1 January 2010

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Drug Development and Industrial Pharmacy

21 August 2017

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21 August 2017

36

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21 August 2017

1

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21 August 2017

1-30

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Inhalation therapy: an historical review.

21 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Particle engineering for pulmonary drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Inhaled nanoparticles--a current review.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

The lung as a route for systemic delivery of therapeutic proteins and peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Systemic delivery of drugs to humans via inhalation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Inhaling medicines: delivering drugs to the body through the lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

The lungs as a portal of entry for systemic drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

A mechanistic approach to understanding the factors affecting drug absorption: a review of fundamentals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

When poor solubility becomes an issue: from early stage to proof of concept

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

A model of the lung interstitial-lymphatic system.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Inhalation of a dry powder tobramycin PulmoSphere formulation in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Safety of inhaled and intranasal corticosteroids: lessons for the new millennium

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Monitoring the initial pulmonary absorption of two different beclomethasone dipropionate aerosols employing a human lung reperfusion model

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Equivalent lung deposition of budesonide in vivo: a comparison of dry powder inhalers using a pharmacokinetic method

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Pulmonary distribution and clearance of two beclomethasone liposome formulations in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Pharmacokinetics of inhaled drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Single-dose and steady-state pharmacokinetic and pharmacodynamic evaluation of therapeutically clinically equivalent doses of inhaled fluticasone propionate and budesonide, given as Diskus or Turbohaler dry-powder inhalers to healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Plasma concentrations of inhaled corticosteroids in relation to airflow obstruction in asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Pharmacokinetics and systemic effects of inhaled fluticasone propionate in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Pharmacokinetics and systemic activity of fluticasone via Diskus and pMDI, and of budesonide via Turbuhaler

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Fluticasone propionate plasma concentration and systemic effect: effect of delivery device and duration of administration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

A study comparing the clinical pharmacokinetics, pharmacodynamics, and tolerability of triamcinolone acetonide HFA-134a metered-dose inhaler and budesonide dry-powder inhaler following inhalation administration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

The pharmacokinetics of nebulized nanocrystal budesonide suspension in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Pharmacokinetics of a novel submicron budesonide dispersion for nebulized delivery in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Beclomethasone dipropionate: absolute bioavailability, pharmacokinetics and metabolism following intravenous, oral, intranasal and inhaled administration in man

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Pharmacokinetics of inhaled monodisperse beclomethasone as a function of particle size

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Development of a dry powder inhaler, the Ultrahaler, containing triamcinolone acetonide using in vitro-in vivo relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Rate-limiting steps of oral absorption for poorly water-soluble drugs in dogs; prediction from a miniscale dissolution test and a physiologically-based computer simulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Advances and challenges in management of invasive mycoses

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

The contribution of animal models of aspergillosis to understanding pathogenesis, therapy and virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Newer systemic antifungal agents : pharmacokinetics, safety and efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Therapy of systemic fungal infections: a pharmacologic perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Characterization of itraconazole/2-hydroxypropyl-beta-cyclodextrin inclusion complex in aqueous propylene glycol solution

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Formulation of parenteral microemulsion containing itraconazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Amphotericin B: current understanding of mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Safety of aerosolized liposomal versus deoxycholate amphotericin B formulations for prevention of invasive fungal infections following lung transplantation: a retrospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Amphotericin B disposition after aerosol inhalation in lung transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Nebulized amphotericin B concentration and distribution in the respiratory tract of lung-transplanted patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Enhanced aqueous dissolution of a poorly water soluble drug by novel particle engineering technology: spray-freezing into liquid with atmospheric freeze-drying.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Novel ultra-rapid freezing particle engineering process for enhancement of dissolution rates of poorly water-soluble drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Nanoparticle engineering processes for enhancing the dissolution rates of poorly water soluble drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

High bioavailability from nebulized itraconazole nanoparticle dispersions with biocompatible stabilizers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Cryogenic liquids, nanoparticles, and microencapsulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Targeted high lung concentrations of itraconazole using nebulized dispersions in a murine model.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Single dose and multiple dose studies of itraconazole nanoparticles.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Increasing exposure levels cause an abrupt change in the absorption and metabolism of acutely inhaled benzo(a)pyrene in the isolated, ventilated, and perfused lung of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Novel poloxamer-based nanoemulsions to enhance the intestinal absorption of active compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

New peptide and protein drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Challenges for the oral delivery of macromolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Novel delivery technologies for protein and peptide therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Is the oral route possible for peptide and protein drug delivery?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Prospects of formulating proteins/peptides as aerosols for pulmonary drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Lung deposition and pharmacokinetics of cyclosporine after aerosolization in lung transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Treatment of refractory acute allograft rejection with aerosolized cyclosporine in lung transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Preclinical safety evaluation of inhaled cyclosporine in propylene glycol.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Amorphous cyclosporin nanodispersions for enhanced pulmonary deposition and dissolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Antidepressant properties of substance P antagonists: relationship to monoaminergic mechanisms?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Improvement of pulmonary absorption of cyclopeptide FK224 in rats by co-formulating with beta-cyclodextrin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Comparison of the lung absorption of FK224 inhaled from a pressurized metered dose inhaler and a dry powder inhaler by healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Current perspectives of solubilization: potential for improved bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Unexpected “gas” casualties in Moscow: A medical toxicology perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Pharmacokinetics of inhaled liposome-encapsulated fentanyl.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Pulmonary administration of aerosolised fentanyl: pharmacokinetic analysis of systemic delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Enhancing intestinal drug solubilisation using lipid-based delivery systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

How the lung handles drugs: pharmacokinetics and pharmacodynamics of inhaled corticosteroids.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

21 January 2018

Penetration enhancers

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Dosimetric adjustments for interspecies extrapolation of inhaled poorly soluble particles (PSP).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

The utility of cyclodextrins for enhancing oral bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Cyclodextrins in drug delivery: an updated review

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Plasma protein binding of amphotericin B and pharmacokinetics of bound versus unbound amphotericin B after administration of intravenous liposomal amphotericin B (AmBisome) and amphotericin B deoxycholate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

Comparative study of budesonide as a nebulized suspension vs pressurized metered-dose inhaler in adult asthmatics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03639040903092319

10.3109/03639040903092319

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

19640248