Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin. (Q37570030)

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16 January 2020

title

Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin (English)

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16 January 2020

6

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16 January 2020

author name string

Lars C Petersen

1

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16 January 2020

Ditte M Karpf

2

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16 January 2020

Henrik Agersø

3

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16 January 2020

Mette B Hermit

4

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16 January 2020

Hermann Pelzer

5

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16 January 2020

Timothy C Nichols

7

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16 January 2020

Mirella Ezban

8

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16 January 2020

language of work or name

English

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publication date

18 November 2010

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British Journal of Haematology

16 January 2020

published in

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16 January 2020

volume

152

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16 January 2020

page(s)

99-107

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16 January 2020

issue

1

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Differential response to bypassing agents complicates treatment in patients with haemophilia and inhibitors

16 January 2020

cites work

1 reference

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Recombinant factor VIIa (rFVIIa): its potential role as a hemostatic agent

23 August 2017

1 reference

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Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity.

23 August 2017

1 reference

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Pharmacokinetics of recombinant activated factor VII (rFVIIa).

23 August 2017

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The clearance of thrombin-antithrombin and related serpin-enzyme complexes from the circulation: role of various hepatocyte receptors

23 August 2017

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Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells

23 August 2017

1 reference

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Effect of recombinant factor VIIa on the hemostatic defect in dogs with hemophilia A, hemophilia B, and von Willebrand disease

23 August 2017

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The effect of cell surface glycosaminoglycans (GAGs) on the inactivation of factor VIIa--tissue factor activity by antithrombin III.

23 August 2017

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Incorporation of an active site inhibitor in factor VIIa alters the affinity for tissue factor

28 September 2017

1 reference

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Measurement of basal levels of factor VIIa in hemophilia A and B patients

28 September 2017

1 reference

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Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelys

28 September 2017

1 reference

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Faster onset of effect and greater efficacy of NN1731 compared with rFVIIa, aPCC and FVIII in tail bleeding in hemophilic mice

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918443

Evaluation of the safety and pharmacokinetics of a fast-acting recombinant FVIIa analogue, NN1731, in healthy male subjects

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918443

Hemostatic biomarkers in dogs with chronic congestive heart failure

1 September 2018

1 reference

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Factor VIIa analogue (V158D/E296V/M298Q-FVIIa) normalises clot formation in whole blood from patients with severe haemophilia A.

1 September 2018

1 reference

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A variant of recombinant factor VIIa with enhanced procoagulant and antifibrinolytic activities in an in vitro model of hemophilia

1 September 2018

1 reference

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Unresponsiveness to factor VIII inhibitor bypassing agents during haemostatic treatment for life-threatening massive bleeding in a patient with haemophilia A and a high responding inhibitor

1 September 2018

1 reference

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Whole blood clot formation phenotypes in hemophilia A and rare coagulation disorders. Patterns of response to recombinant factor VIIa

1 September 2018

1 reference

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Improved hemostasis with superactive analogs of factor VIIa in a mouse model of hemophilia A.

1 September 2018

1 reference

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Complex-dependent inhibition of factor VIIa by antithrombin III and heparin.

1 September 2018

1 reference

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Pharmacokinetics and pharmacodynamics of recombinant factor VIIa

1 September 2018

1 reference

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Plasma elimination kinetics for factor VII are independent of its activation to factor VIIa and complex formation with plasma inhibitors

1 September 2018

1 reference

12 December 2020

Factor VIIa-antithrombin complexes in patients with arterial and venous thrombosis

1 reference

12 December 2020

Prolonged effect of GlycoPEGylated rFVIIa (40k-PEG-rFVIIa) in rabbits correlates to activity in plasma

1 reference

12 December 2020

Accelerating ability of synthetic oligosaccharides on antithrombin inhibition of proteinases of the clotting and fibrinolytic systems. Comparison with heparin and low-molecular-weight heparin

1 reference

12 December 2020

Regulation of factor VIIa activity in plasma: evidence that antithrombin III is the sole plasma protease inhibitor of human factor VIIa

1 reference

12 December 2020

Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation

1 reference

12 December 2020

10.1111/J.1365-2141.2010.08432.X

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21083658%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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16 January 2020

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