Targeting FtsZ for antibacterial therapy: a promising avenue (Q37573808)

21 August 2017

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title

Targeting FtsZ for antibacterial therapy: a promising avenue (English)

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21 August 2017

Sonia Kapoor

1

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21 August 2017

Dulal Panda

series ordinal

2

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21 August 2017

language of work or name

English

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publication date

1 September 2009

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Expert Opinion on Therapeutic Targets

21 August 2017

published in

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21 August 2017

volume

13

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21 August 2017

issue

9

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21 August 2017

page(s)

1037-1051

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A global view of antibiotic resistance

21 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

FtsZ ring structure associated with division in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Bacterial cell division: the mechanism and its precison

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

The regulation of bacterial cell division: a time and place for it.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Assembly dynamics of the bacterial MinCDE system and spatial regulation of the Z ring

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

The prokaryotic cytoskeleton: a putative target for inhibitors and antibiotics?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

FtsZ: a novel target for tuberculosis drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Cell-division inhibitors: new insights for future antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Concentration and Assembly of the Division Ring Proteins FtsZ, FtsA, and ZipA during the Escherichia coli Cell Cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Assembly Dynamics of the Bacterial Cell Division Protein FtsZ: Poised at the Edge of Stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Rapid assembly dynamics of the Escherichia coli FtsZ-ring demonstrated by fluorescence recovery after photobleaching

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Kinetic modeling of the assembly, dynamic steady state, and contraction of the FtsZ ring in prokaryotic cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

FtsZ condensates: an in vitro electron microscopy study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Temperature shift experiments with an ftsZ84(Ts) strain reveal rapid dynamics of FtsZ localization and indicate that the Z ring is required throughout septation and cannot reoccupy division sites once constriction has initiated

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

FtsZ ring in bacterial cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Tubulin and FtsZ form a distinct family of GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

GTP-dependent polymerization of Escherichia coli FtsZ protein to form tubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Guanine nucleotide-dependent assembly of FtsZ into filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Ca2+-mediated GTP-dependent dynamic assembly of bacterial cell division protein FtsZ into asters and polymer networks in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

An analysis of FtsZ assembly using small angle X-ray scattering and electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Glutamate-induced assembly of bacterial cell division protein FtsZ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Effects of pH and ionic strength on the assembly and bundling of FtsZ protofilaments: a possible role of electrostatic interactions in the bundling of protofilaments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Essential cell division protein FtsZ assembles into one monomer-thick ribbons under conditions resembling the crowded intracellular environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

ZipA is a MAP-Tau homolog and is essential for structural integrity of the cytokinetic FtsZ ring during bacterial cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

SepF increases the assembly and bundling of FtsZ polymers and stabilizes FtsZ protofilaments by binding along its length

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Escherichia coli FtsZ polymers contain mostly GTP and have a high nucleotide turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

FtsZ filament dynamics at steady state: subunit exchange with and without nucleotide hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

The interactions of cell division protein FtsZ with guanine nucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Straight and curved conformations of FtsZ are regulated by GTP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

The structure of FtsZ filaments in vivo suggests a force-generating role in cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Antibacterial drug discovery and structure-based design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

ftsZ is an essential cell division gene in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Spatial control of bacterial division-site placement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

SlmA, a nucleoid-associated, FtsZ binding protein required for blocking septal ring assembly over Chromosomes in E. coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Coordination of cell division and chromosome segregation by a nucleoid occlusion protein in Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Shape determination in Bacillus subtilis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Overview of cell shape: cytoskeletons shape bacterial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Force generation by a dynamic Z-ring in Escherichia coli cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Modeling the physics of FtsZ assembly and force generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Reconstitution of contractile FtsZ rings in liposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

In vivo characterization of Escherichia coli ftsZ mutants: effects on Z-ring structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

ftsZ mutations affecting cell division frequency, placement and morphology in Bacillus subtilis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Mutants of FtsZ targeting the protofilament interface: effects on cell division and GTPase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

New temperature-sensitive alleles of ftsZ in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

21 January 2018

Bacterial cell division.

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Rational identification of new antibacterial drug targets that are essential for viability using a genomics-based approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

FtsZ, a prokaryotic homolog of tubulin?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Structural/functional homology between the bacterial and eukaryotic cytoskeletons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

The tubulin ancestor, FtsZ, draughtsman, designer and driving force for bacterial cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Molecules of the bacterial cytoskeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Dynamic Filaments of the Bacterial Cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Totarol inhibits bacterial cytokinesis by perturbing the assembly dynamics of FtsZ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Structural mechanisms underlying nucleotide-dependent self-assembly of tubulin and its relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Has nature already identified all useful antibacterial targets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

An inhibitor of FtsZ with potent and selective anti-staphylococcal activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Crystal structure of the bacterial cell-division protein FtsZ

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Crystal structure of the SOS cell division inhibitor SulA and in complex with FtsZ

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Structural insights into the conformational variability of FtsZ

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Computational chemistry-driven decision making in lead generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Synergism between natural products and antibiotics against infectious diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Sanguinarine blocks cytokinesis in bacteria by inhibiting FtsZ assembly and bundling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding. A possible mechanism for its antiproliferative activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Inhibition of bacterial cell division protein FtsZ by cinnamaldehyde.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Berberine targets assembly of Escherichia coli cell division protein FtsZ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

A new 2-carbamoyl pteridine that inhibits mycobacterial FtsZ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

A 4-aminofurazan derivative-A189-inhibits assembly of bacterial cell division protein FtsZ in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Parallel solid synthesis of inhibitors of the essential cell division FtsZ enzyme as a new potential class of antibacterials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Sublethal concentrations of the aminoglycoside amikacin interfere with cell division without affecting chromosome dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Peptides as protein binding site mimetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Inhibiting protein-protein interactions using designed molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Division protein interaction web: identification of a phylogenetically conserved common interactome between Streptococcus pneumoniae and Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Protein interaction networks in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

FtsZ and the division of prokaryotic cells and organelles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

A metabolic sensor governing cell size in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Unique and overlapping roles for ZipA and FtsA in septal ring assembly in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

ZipA is required for recruitment of FtsK, FtsQ, FtsL, and FtsN to the septal ring in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

A widely conserved bacterial cell division protein that promotes assembly of the tubulin-like protein FtsZ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

A membrane protein, EzrA, regulates assembly dynamics of FtsZ by interacting with the C-terminal tail of FtsZ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

The ClpX chaperone modulates assembly of the tubulin-like protein FtsZ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Cell division inhibitors SulA and MinCD prevent formation of the FtsZ ring

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

A division inhibitor and a topological specificity factor coded for by the minicell locus determine proper placement of the division septum in E. coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

The MinC component of the division site selection system in Escherichia coli interacts with FtsZ to prevent polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Assembly of cell division proteins at the E. coli cell center

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Diverse paths to midcell: assembly of the bacterial cell division machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Direct binding of FtsZ to ZipA, an essential component of the septal ring structure that mediates cell division in E. coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

The bacterial cell-division protein ZipA and its interaction with an FtsZ fragment revealed by X-ray crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Solution structure of ZipA, a crucial component of Escherichia coli cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Development of a fluorescence polarization assay to screen for inhibitors of the FtsZ/ZipA interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Microtubule assembly dynamics: an attractive target for anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Can virulence factors be viable antibacterial targets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Outer membrane permeability and antibiotic resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Crystallizing new approaches for antimicrobial drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Evidence for functional overlap among multiple bacterial cell division proteins: compensating for the loss of FtsK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

An altered FtsA can compensate for the loss of essential cell division protein FtsN in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Compensation for the loss of the conserved membrane targeting sequence of FtsA provides new insights into its function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

Escherichia coli cell-division gene ftsZ encodes a novel GTP-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

The essential bacterial cell-division protein FtsZ is a GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903173257

10.1517/14728220903173257

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference