30 years and a long way into p53 research (Q37589207)

21 August 2017

30 years and a long way into p53 research (English)

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21 August 2017

Pierre Hainaut

1

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PubMed ID

19717093

21 August 2017

Klas G Wiman

series ordinal

2

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21 August 2017

1 September 2009

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Lancet Oncology Commission

21 August 2017

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21 August 2017

10

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21 August 2017

9

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21 August 2017

913-919

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Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

21 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Mutations in the p53 gene occur in diverse human tumour types

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Sun protection factor p53

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Sunburn and p53 in the onset of skin cancer

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

The history of tumor virology

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

T antigen is bound to a host protein in SY40-transformed cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Identification and partial characterization of new antigens from simian virus 40-transformed mouse cells

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Abelson murine leukemia virus-induced tumors elicit antibodies against a host cell protein, P50

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Cloning and expression analysis of full length mouse cDNA sequences encoding the transformation associated protein p53.

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

The cellular oncogene p53 can be activated by mutagenesis.

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytes.

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Wild-type p53 can inhibit oncogene-mediated focus formation

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

The p53 proto-oncogene can act as a suppressor of transformation

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

p53 mutations in human cancers

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Cancer. p53, guardian of the genome

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

p53 is required for radiation-induced apoptosis in mouse thymocytes

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Identification of p53 as a sequence-specific DNA-binding protein

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

A transcriptionally active DNA-binding site for human p53 protein complexes

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Definition of a consensus binding site for p53

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Wild-type p53 activates transcription in vitro

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

WAF1, a potential mediator of p53 tumor suppression

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

mdm2 expression is induced by wild type p53 activity

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

The p53-mdm-2 autoregulatory feedback loop

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

1 reference

7 January 2021

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Regulation of p53 stability by Mdm2

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Mdm2 promotes the rapid degradation of p53

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

DNA damage induces phosphorylation of the amino terminus of p53

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

A novel protein with strong homology to the tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

p53 isoforms can regulate p53 transcriptional activity.

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

p53 protein variants: structural and functional similarities with p63 and p73 isoforms

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Regulation of human p53 activity and cell localization by alternative splicing

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

p53 Stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Pharmacological rescue of mutant p53 conformation and function

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

An oncogene-induced DNA damage model for cancer development

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Restoration of p53 function leads to tumour regression in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Modeling the therapeutic efficacy of p53 restoration in tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

p53 mutant mice that display early ageing-associated phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

MicroRNA-125b is a novel negative regulator of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

p53-mediated activation of miRNA34 candidate tumor-suppressor genes.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

A microRNA component of the p53 tumour suppressor network

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https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Transcriptional activation of miR-34a contributes to p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

The p53 knowledgebase: an integrated information resource for p53 research.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

p53 isoforms - a conspiracy to kidnap p53 tumor suppressor activity?

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2809%2970198-6

7 January 2021

10.1016/S1470-2045(09)70198-6

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

19717093