The role of the complement system and the activation fragment C5a in the central nervous system (Q37599686)

21 August 2017

The role of the complement system and the activation fragment C5a in the central nervous system (English)

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21 August 2017

Trent M Woodruff

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author name string

Rahasson R Ager

2

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21 August 2017

Andrea J Tenner

3

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21 August 2017

Peter G Noakes

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21 August 2017

Stephen M Taylor

5

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21 August 2017

11 September 2009

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21 August 2017

NeuroMolecular Medicine

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21 August 2017

12

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21 August 2017

2

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21 August 2017

179-192

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https://scigraph.springernature.com/pub.10.1007/s12017-009-8085-y

21 August 2017

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cites work

The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis

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12 December 2020

Identification of complement 5a-like receptor (C5L2) from astrocytes: characterization of anti-inflammatory properties

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12 December 2020

Antibody-independent activation of the complement system by mitochondria is mediated by cardiolipin

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12 December 2020

Expression of the anaphylatoxin C5a receptor in the oligodendrocyte lineage.

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12 December 2020

Identification of four novel human G protein-coupled receptors expressed in the brain

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12 December 2020

Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes

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12 December 2020

Role of complement anaphylatoxin receptors (C3aR, C5aR) in the development of the rat cerebellum

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12 December 2020

Protective immune responses against West Nile virus are primed by distinct complement activation pathways

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12 December 2020

Expression of complement C4 and C9 genes by human astrocytes.

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12 December 2020

Immune surveillance of the human central nervous system (CNS): different migration pathways of immune cells through the blood-brain barrier and blood-cerebrospinal fluid barrier in healthy persons

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12 December 2020

Complement: a novel factor in basal and ischemia-induced neurogenesis

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12 December 2020

Protective effect of C5a receptor inhibition after murine reperfused stroke

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12 December 2020

Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo

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12 December 2020

Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons

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12 December 2020

Kinetics of anaphylatoxin C5a receptor expression during experimental allergic encephalomyelitis

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12 December 2020

Complement activation by neurofibrillary tangles in Alzheimer's disease.

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12 December 2020

Complement components of the innate immune system in health and disease in the CNS.

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12 December 2020

Localization and cell association of C1q in Alzheimer's disease brain

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12 December 2020

C5 deficiency and C5a or C5aR blockade protects against cerebral malaria

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12 December 2020

Molecular organization of C9 within the membrane attack complex of complement. Induction of circular C9 polymerization by the C5b-8 assembly

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12 December 2020

Innate immunity in viral encephalitis: role of C5

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12 December 2020

A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells

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12 December 2020

Complement component C1q inhibits beta-amyloid- and serum amyloid P-induced neurotoxicity via caspase- and calpain-independent mechanisms.

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12 December 2020

Expression of a functional C5a receptor in regenerating hepatocytes and its involvement in a proliferative signaling pathway in rat

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12 December 2020

Increased complement biosynthesis by microglia and complement activation on neurons in Huntington's disease

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12 December 2020

Expression of C5a receptor in mouse brain: role in signal transduction and neurodegeneration.

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12 December 2020

Complement C1-inhibitor expression in Alzheimer's disease.

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12 December 2020

Expression of the receptors for the C5a anaphylatoxin, interleukin-8 and FMLP by human astrocytes and microglia

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12 December 2020

Experimental diffuse axonal injury induces enhanced neuronal C5a receptor mRNA expression in rats.

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12 December 2020

Interleukin-1 and tumor necrosis factor-mediated regulation of C3 gene expression in human astroglioma cells

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12 December 2020

beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.

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12 December 2020

Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system.

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12 December 2020

Spontaneous classical pathway activation and deficiency of membrane regulators render human neurons susceptible to complement lysis

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12 December 2020

Synergistic neuroprotective effects of C3a and C5a receptor blockade following intracerebral hemorrhage

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12 December 2020

Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease

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12 December 2020

Complement activation in amyloid plaques in Alzheimer's dementia.

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12 December 2020

Cytokines associated with amyloid plaques in Alzheimer's disease brain stimulate human glial and neuronal cell cultures to secrete early complement proteins, but not C1-inhibitor.

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12 December 2020

Complement activation on human neuroblastoma cell lines in vitro: route of activation and expression of functional complement regulatory proteins.

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12 December 2020

Studies on the interactions between C-reactive protein and complement proteins.

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12 December 2020

Neuronal expression of a functional receptor for the C5a complement activation fragment

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12 December 2020

C5b-9 complement complex in autoimmune demyelination and multiple sclerosis: dual role in neuroinflammation and neuroprotection

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12 December 2020

Production and interferon-gamma-mediated regulation of complement component C2 and factors B and D by the astroglioma cell line U105-MG

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12 December 2020

Systemic complement depletion diminishes perihematomal brain edema in rats

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12 December 2020

Complement regulator loss on apoptotic neuronal cells causes increased complement activation and promotes both phagocytosis and cell lysis

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12 December 2020

The expression of complement regulatory proteins by adult human oligodendrocytes

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12 December 2020

Complement activation in experimental human malaria infection.

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12 December 2020

Blocking the receptor for C5a in patients with rheumatoid arthritis does not reduce synovial inflammation

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12 December 2020

Antibody-independent killing of gram-negative bacteria via the classical pathway of complement

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12 December 2020

The Membrane Attack Complex of Complement Causes Severe Demyelination Associated with Acute Axonal Injury

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12 December 2020

Complement C5a receptor-mediated signaling may be involved in neurodegeneration in Alzheimer's disease

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12 December 2020

Oligodendrocyte cell death in pathogenesis of multiple sclerosis: Protection of oligodendrocytes from apoptosis by complement

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12 December 2020

Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel disease

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12 December 2020

The complement factor C5a receptor is upregulated in NFL-/- mouse motor neurons

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12 December 2020

Complement gene expression in neuroblastoma and astrocytoma cell lines of human origin

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12 December 2020

Neuronal localization of C1q in preclinical Alzheimer's disease

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12 December 2020

Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells

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12 December 2020

Human astrocytes express membrane cofactor protein (CD46), a regulator of complement activation

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12 December 2020

Complement and cytokine gene expression in cultured microglial derived from postmortem human brains

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12 December 2020

Expression of cytokines by human astrocytomas following stimulation by C3a and C5a anaphylatoxins: specific increase in interleukin-6 mRNA expression

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12 December 2020

Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide

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12 December 2020

Role of complement in motor neuron disease: animal models and therapeutic potential of complement inhibitors.

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12 December 2020

The complement-derived anaphylatoxin C5a increases microglial GLT-1 expression and glutamate uptake in a TNF-alpha-independent manner

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12 December 2020

Early plasma complement C3a levels correlate with functional outcome after aneurysmal subarachnoid hemorrhage

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12 December 2020

Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity.

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12 December 2020

Anaphylatoxin C5a receptor mRNA is strongly expressed in Kupffer and stellate cells and weakly in sinusoidal endothelial cells but not in hepatocytes of normal rat liver.

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12 December 2020

Complement C5a anaphylatoxin fragment causes apoptosis in TGW neuroblastoma cells

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12 December 2020

Blockade of the C5a receptor fails to protect against experimental autoimmune encephalomyelitis in rats

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12 December 2020

Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation

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12 December 2020

C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism

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12 December 2020

Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity.

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12 December 2020

Disruption of the C5a receptor gene fails to protect against experimental allergic encephalomyelitis.

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12 December 2020

Evidence for a functional role of the second C5a receptor C5L2.

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12 December 2020

Antibody-independent C1 activation by E. coli

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12 December 2020

The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)

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12 December 2020

Detection of mosaic protein mRNA in human astrocytes.

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12 December 2020

Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease.

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12 December 2020

Functional roles for C5a receptors in sepsis

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12 December 2020

Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions

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12 December 2020

Gene expression analysis of the murine model of amyotrophic lateral sclerosis: studies of the Leu126delTT mutation in SOD1.

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12 December 2020

Expression of C5a in the brain does not exacerbate experimental autoimmune encephalomyelitis.

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12 December 2020

Primary cultures of murine astrocytes produce C3 and factor B, two components of the alternative pathway of complement activation.

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12 December 2020

The receptor for complement anaphylatoxin C3a is expressed by myeloid cells and nonmyeloid cells in inflamed human central nervous system: analysis in multiple sclerosis and bacterial meningitis.

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12 December 2020

Complement: an inflammatory pathway fulfilling multiple roles at the interface of innate immunity and development.

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12 December 2020

Generation of C5a by phagocytic cells

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12 December 2020

The role of complement anaphylatoxin C5a in neurodegeneration: implications in Alzheimer's disease.

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12 December 2020

Activation of complement in the central nervous system: roles in neurodegeneration and neuroprotection

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12 December 2020

Generation of C5a in the absence of C3: a new complement activation pathway

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12 December 2020

Expression of a complete and functional complement system by human neuronal cells in vitro

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12 December 2020

C5a receptor expression by TGW neuroblastoma cells

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12 December 2020

Molecular cloning and characterization of the human anaphylatoxin C3a receptor

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12 December 2020

Expression of the complement classical pathway by human glioma in culture. A model for complement expression by nerve cells.

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12 December 2020

Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation.

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12 December 2020

Detection of complement protein mRNA in human astrocytes by the polymerase chain reaction

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12 December 2020

Complement gene expression in human brain: comparison between normal and Alzheimer disease cases

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12 December 2020

Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphotoxin-alpha following closed head injury in mice

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12 December 2020

Complement-targeted therapeutics

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12 December 2020

Expression of decay-accelerating factor (CD55), membrane cofactor protein (CD46) and CD59 in the human astroglioma cell line, D54-MG, and primary rat astrocytes

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12 December 2020

Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines

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12 December 2020

Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G-protein and the rearrangement of the actin cytoskeleton

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12 December 2020

Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS.

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12 December 2020

Detection of the membrane inhibitor of reactive lysis (CD59) in diseased neurons of Alzheimer brain

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12 December 2020

C1q binding and C1 activation by various isolated cellular membranes.

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12 December 2020

Complement regulatory protein expression by a human oligodendrocyte cell line: cytokine regulation and comparison with astrocytes.

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12 December 2020

The classical complement cascade mediates CNS synapse elimination

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12 December 2020

Cell mediators of inflammation in the Alzheimer disease brain

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12 December 2020

Expression of complement components of the alternative pathway by glioma cell lines

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12 December 2020

Complement activation contributes to hypoxic-ischemic brain injury in neonatal rats.

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12 December 2020

Complement anaphylatoxin C5a neuroprotects through mitogen-activated protein kinase-dependent inhibition of caspase 3.

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12 December 2020

Expression of complement messenger RNAs and proteins by human oligodendroglial cells.

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12 December 2020

Induction of decay-accelerating factor by cytokines or the membrane-attack complex protects vascular endothelial cells against complement deposition

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12 December 2020

Molecular and cellular characterization of the membrane attack complex, C5b-9, in Alzheimer's disease

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12 December 2020

Characterization of C3a and C5a receptors in rat cerebellar granule neurons during maturation. Neuroprotective effect of C5a against apoptotic cell death

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12 December 2020

Interferon-gamma regulation of C3 gene expression in human astroglioma cells

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12 December 2020

Complement consumption in children with Plasmodium falciparum malaria

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12 December 2020

Plaque complement activation and cognitive loss in Alzheimer's disease

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12 December 2020

Identification and characterization of complement C3 receptors on human astrocytes

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12 December 2020

Chemotaxis by a CNS macrophage, the microglia

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12 December 2020

Microglial cell migration stimulated by ATP and C5a involve distinct molecular mechanisms: quantification of migration by a novel near-infrared method

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12 December 2020

An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2

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12 December 2020

Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease.

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12 December 2020

Complement C1 inhibitor is produced by brain tissue and is cleaved in Alzheimer disease

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12 December 2020

Type 1 astrocytes and oligodendrocyte-type 2 astrocyte glial progenitors migrate toward distinct molecules

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12 December 2020

Enhanced expression of chemotactic receptors in multiple sclerosis lesions.

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12 December 2020

Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity.

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12 December 2020

Bacterial meningitis: complement gene expression in the central nervous system

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12 December 2020

Expression of a functional anaphylatoxin C3a receptor by astrocytes.

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12 December 2020

Human oligodendrocytes are not sensitive to complement. A study of CD59 expression in the human central nervous system

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12 December 2020

Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung

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12 December 2020

Deletion of the complement anaphylatoxin C3a receptor attenuates, whereas ectopic expression of C3a in the brain exacerbates, experimental autoimmune encephalomyelitis

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12 December 2020

Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria

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12 December 2020

Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer's disease

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12 December 2020

Expression of Receptors for Complement Anaphylatoxins C3a and C5a Following Permanent Focal Cerebral Ischemia in the Mouse

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12 December 2020

Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration

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12 December 2020

Control of the complement system.

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12 December 2020

Mechanisms of C5a and C3a complement fragment-induced [Ca2+]i signaling in mouse microglia

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12 December 2020

Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat.

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12 December 2020

The relative importance of local and systemic complement production in ischaemia, transplantation and other pathologies.

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12 December 2020

Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist.

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12 December 2020

TNF-alpha-mediated expression of the receptor for anaphylatoxin C5a on neurons in experimental Listeria meningoencephalitis

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12 December 2020

Alterations in plasma complement levels after human ischemic stroke.

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12 December 2020

The chemotactic receptor for human C5a anaphylatoxin

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12 December 2020

Liposome-induced activation of the classical complement pathway does not require immunoglobulin

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12 December 2020

10.1007/S12017-009-8085-Y

Identifiers

DOI

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21 August 2017

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