Cyclotides: macrocyclic peptides with applications in drug design and agriculture (Q37606347)

21 August 2017

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title

Cyclotides: macrocyclic peptides with applications in drug design and agriculture (English)

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21 August 2017

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1

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21 August 2017

Joshua S Mylne

2

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Norelle L Daly

object named as

Norelle L Daly

series ordinal

3

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publication date

1 October 2009

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Cellular and Molecular Life Sciences

21 August 2017

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21 August 2017

67

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21 August 2017

1

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21 August 2017

9-16

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https://scigraph.springernature.com/pub.10.1007/s00018-009-0159-3

21 August 2017

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cites work

Variations in cyclotide expression in viola species

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12 December 2020

Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins

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12 December 2020

Biosynthesis of a fully functional cyclotide inside living bacterial cells.

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12 December 2020

Squash trypsin inhibitors from Momordica cochinchinensis exhibit an atypical macrocyclic structure

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12 December 2020

Studies on the membrane interactions of the cyclotides kalata B1 and kalata B6 on model membrane systems by surface plasmon resonance

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12 December 2020

Mechanism of action of cytotoxic cyclotides: cycloviolacin O2 disrupts lipid membranes.

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12 December 2020

Protease-catalysed protein splicing: a new post-translational modification?

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12 December 2020

Evaluation and improvement of the properties of the novel cystine-knot microprotein McoEeTI for oral administration.

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12 December 2020

Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity.

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12 December 2020

The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity

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12 December 2020

Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes

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12 December 2020

Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity

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12 December 2020

Despite a Conserved Cystine Knot Motif, Different Cyclotides Have Different Membrane Binding Modes

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12 December 2020

Cyclic peptides from Oldenlandia affinis DC. Molecular and biological properties

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12 December 2020

Cyclotides as natural anti-HIV agents.

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12 December 2020

15N cyclotides by whole plant labeling

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12 December 2020

The biological activity of the prototypic cyclotide kalata b1 is modulated by the formation of multimeric pores

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12 December 2020

Circular proteins from Melicytus (Violaceae) refine the conserved protein and gene architecture of cyclotides

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12 December 2020

Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms.

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12 December 2020

Chemical synthesis and folding pathways of large cyclic polypeptides: studies of the cystine knot polypeptide kalata B1.

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12 December 2020

Novel strategies for isolation and characterization of cyclotides: the discovery of bioactive macrocyclic plant polypeptides in the Violaceae

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12 December 2020

Dissecting defense-related and developmental transcriptional responses of maize during Ustilago maydis infection and subsequent tumor formation

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12 December 2020

Chemistry. Seamless proteins tie up their loose ends

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12 December 2020

A global assembly line for cyanobactins

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12 December 2020

A novel plant protein-disulfide isomerase involved in the oxidative folding of cystine knot defense proteins.

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12 December 2020

Quantitative analysis of backbone-cyclised peptides in plants

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12 December 2020

Arabidopsis protein disulfide isomerase-5 inhibits cysteine proteases during trafficking to vacuoles before programmed cell death of the endothelium in developing seeds

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12 December 2020

Insecticidal plant cyclotides and related cystine knot toxins

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12 December 2020

Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae

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12 December 2020

Seven novel macrocyclic polypeptides from Viola arvensis

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12 December 2020

Oldenlandia affinis (R&S;) DC. A plant containing uteroactive peptides used in African traditional medicine

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12 December 2020

Discovery of cyclotide-like protein sequences in graminaceous crop plants: ancestral precursors of circular proteins?

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12 December 2020

Cyclotides: a novel type of cytotoxic agents

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12 December 2020

Peptide AS-48: prototype of a new class of cyclic bacteriocins.

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12 December 2020

Oxidative folding of cyclic cystine knot proteins.

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12 December 2020

Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif

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12 December 2020

An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides

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12 December 2020

Divalent cation coordination and mode of membrane interaction in cyclotides: NMR spatial structure of ternary complex Kalata B7/Mn2+/DPC micelle

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12 December 2020

Backbone cyclised peptides from plants show molluscicidal activity against the rice pest Pomacea canaliculata (golden apple snail).

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12 December 2020

The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug delivery

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12 December 2020

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12 December 2020

An asparaginyl endopeptidase mediates in vivo protein backbone cyclization.

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12 December 2020

Inhibition of platelet aggregation by grafting RGD and KGD sequences on the structural scaffold of small disulfide-rich proteins

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12 December 2020

A comparison of the self-association behavior of the plant cyclotides kalata B1 and kalata B2 via analytical ultracentrifugation.

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12 December 2020

Key role of glutamic acid for the cytotoxic activity of the cyclotide cycloviolacin O2.

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12 December 2020

Distribution and evolution of circular miniproteins in flowering plants

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12 December 2020

Total chemical synthesis of proteins

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12 December 2020

Plant cell culture technology-harnessing a biological approach for competitive cyclotides production

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12 December 2020

Plant cyclotides: an unusual class of defense compounds.

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12 December 2020

Potential therapeutic applications of the cyclotides and related cystine knot mini-proteins

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12 December 2020

The anthelmintic activity of the cyclotides: natural variants with enhanced activity

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12 December 2020

Fractionation Protocol for the Isolation of Polypeptides from Plant Biomass

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12 December 2020

Chemical synthesis and biosynthesis of the cyclotide family of circular proteins

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12 December 2020

Gene family encoding the major toxins of lethal Amanita mushrooms

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12 December 2020

Acyclic permutants of naturally occurring cyclic proteins. Characterization of cystine knot and beta-sheet formation in the macrocyclic polypeptide kalata B1.

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12 December 2020

Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides

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12 December 2020

Twists, knots, and rings in proteins. Structural definition of the cyclotide framework

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12 December 2020

A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins

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12 December 2020

Biosynthesis and insecticidal properties of plant cyclotides: the cyclic knotted proteins from Oldenlandia affinis

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12 December 2020

Biosynthesis of circular proteins in plants

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12 December 2020

Circling the enemy: cyclic proteins in plant defence

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12 December 2020

Formation of cyclotides and variations in cyclotide expression in Oldenlandia affinis suspension cultures

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12 December 2020

Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature?

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12 December 2020

Reversible antifouling effect of the cyclotide cycloviolacin O2 against barnacles

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12 December 2020

Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides.

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12 December 2020

Identification of two suites of cyclotide precursor genes from metallophyte Viola baoshanensis: cDNA sequence variation, alternative RNA splicing and potential cyclotide diversity

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12 December 2020

Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep.

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12 December 2020

Conformation and mode of membrane interaction in cyclotides. Spatial structure of kalata B1 bound to a dodecylphosphocholine micelle

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12 December 2020

The chemistry and biology of cyclotides.

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12 December 2020

Immobilized protease-assisted synthesis of engineered cysteine-knot microproteins.

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12 December 2020

Circular proteins--no end in sight

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12 December 2020

10.1007/S00018-009-0159-3

Identifiers

DOI

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21 August 2017

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PubMed ID

19795188