Molecular changes in pancreatic cancer (Q37614592)

21 August 2017

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title

Molecular changes in pancreatic cancer (English)

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21 August 2017

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Thomas M Gress

2

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author name string

Malte Buchholz

series ordinal

1

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21 August 2017

1 October 2009

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Expert Review of Anticancer Therapy

21 August 2017

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21 August 2017

9

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21 August 2017

10

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21 August 2017

1487-1497

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Pancreatic cancer: basic and clinical aspects

21 August 2017

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https://api.crossref.org/works/10.1586%2FERA.09.107

An introduction to pancreatic adenocarcinoma genetics, pathology and therapy.

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

21 January 2018

Cancer statistics, 2007

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https://api.crossref.org/works/10.1586%2FERA.09.107

A new approach to managing intraductal papillary mucinous pancreatic neoplasms

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Finishing the euchromatic sequence of the human genome

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Identification of genetic alterations in pancreatic cancer by the combined use of tissue microdissection and array-based comparative genomic hybridisation.

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Genomic DNA-chip hybridization reveals a higher incidence of genomic amplifications in pancreatic cancer than conventional comparative genomic hybridization and leads to the identification of novel candidate genes

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Genome-wide aberrations in pancreatic adenocarcinoma.

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Gene expression profiles of pancreatic cancer and stromal desmoplasia

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Expression profiling of microdissected pancreatic adenocarcinomas

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Discovery of novel tumor markers of pancreatic cancer using global gene expression technology

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Gene expression profiles of microdissected pancreatic ductal adenocarcinoma.

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Expression profiling identifies microRNA signature in pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma.

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Proteomic profiling of pancreatic cancer for biomarker discovery

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Pancreatic cancer proteome: the proteins that underlie invasion, metastasis, and immunologic escape

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry.

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

CpG island methylation profile of pancreatic intraepithelial neoplasia

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Epigenetic alterations in intraductal papillary mucinous neoplasms of the pancreas

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Epigenetic down-regulation of CDKN1C/p57KIP2 in pancreatic ductal neoplasms identified by gene expression profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Precursors to invasive pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

The pathology of ductal-type pancreatic carcinomas and pancreatic intraepithelial neoplasia: insights for clinicians

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Update on the pathology and genetics of exocrine pancreatic tumors with ductal phenotype: precursor lesions and new tumor entities

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Identification of pancreatic cancer stem cells

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Notch signalling controls pancreatic cell differentiation

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Notch signaling: where pancreatic cancer and differentiation meet?

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Notch signaling controls multiple steps of pancreatic differentiation

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Hedgehog/Ras interactions regulate early stages of pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Epithelial-cadherin and beta-catenin expression changes in pancreatic intraepithelial neoplasia

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

WNT5A--target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Pancreatic intraductal sampling during ERCP in patients with chronic pancreatitis and pancreatic cancer: cytologic studies and k-ras-2 codon 12 molecular analysis in 47 cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Principles of tumor suppression

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Basement membrane component laminin-5 is a target of the tumor suppressor Smad4.

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells.

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

The biology of VEGF and its receptors

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Vascular endothelial growth factor-trap suppresses tumorigenicity of multiple pancreatic cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Gene therapy for pancreatic cancer using an adenovirus vector encoding soluble flt-1 vascular endothelial growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Evaluation of vascular endothelial growth factor blockade and matrix metalloproteinase inhibition as a combination therapy for experimental human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Antiangiogenic versus cytotoxic therapeutic approaches to human pancreas cancer: an experimental study with a vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor and gemcitabine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Pancreatic cancer growth is inhibited by blockade of VEGF-RII.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: an open-label randomised phase II study

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Biological approaches to therapy of pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Clinical implications of the mechanism of epidermal growth factor receptor inhibitors

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Epidermal growth factor receptor expression in pancreatic carcinoma using tissue microarray technique

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

The epidermal growth factor receptor in human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Phosphorylated Akt/PKB controls cell growth and apoptosis in intraductal papillary-mucinous tumor and invasive ductal adenocarcinoma of the pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

In vivo antitumor effect of the mTOR inhibitor CCI-779 and gemcitabine in xenograft models of human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Dominant negative inhibitors of signalling through the phosphoinositol 3-kinase pathway for gene therapy of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Frequent activation of AKT2 kinase in human pancreatic carcinomas

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Tumor COX-2 expression and prognosis of patients with resectable pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Cyclooxygenase-2 expression in human pancreatic adenocarcinomas

21 January 2018

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https://api.crossref.org/works/10.1586%2FERA.09.107

Cyclooxygenases and lipoxygenases as potential targets for treatment of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Regulation of cyclooxygenase-2 (COX-2) expression in human pancreatic carcinoma cells by the insulin-like growth factor-I receptor (IGF-IR) system

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

The role of the IGF system in cancer: from basic to clinical studies and clinical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Aberrant expression and activation of insulin-like growth factor-1 receptor (IGF-1R) are mediated by an induction of IGF-1R promoter activity and stabilization of IGF-1R mRNA and contributes to growth factor independence and increased survival of th

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Clinical significance of focal adhesion kinase in resectable pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Expression and activity of SRC regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Tyrosine kinase inhibitors and gemcitabine: new treatment options in pancreatic cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Antitumor effects and biomarkers of activity of AZD0530, a Src inhibitor, in pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Gastrin, CCK, signaling, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

The functional significance of the cholecystokinin-C (CCK-C) receptor in human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Targeting survivin in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Survivin expression and its clinical significance in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Expression of survivin, a novel inhibitor of apoptosis and cell cycle regulatory protein, in pancreatic adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Potentiation of the effect of gemcitabine by emodin in pancreatic cancer is associated with survivin inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Shh signaling and pancreatic cancer: implications for therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Pten constrains centroacinar cell expansion and malignant transformation in the pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Pancreatic ductal adenocarcinoma: cellular origin, signaling pathways and stroma contribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

Wnt-beta-catenin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERA.09.107

21 January 2018

Identifiers

DOI

10.1586/ERA.09.107

1 reference

21 August 2017

1 reference

PubMed ID

19828010