Plasmodium falciparum: new molecular targets with potential for antimalarial drug development (Q37626063)

21 August 2017

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title

Plasmodium falciparum: new molecular targets with potential for antimalarial drug development (English)

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21 August 2017

Plasmodium falciparum

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4

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21 August 2017

Donald L Gardiner

1

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21 August 2017

Tina S Skinner-Adams

2

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21 August 2017

Christopher L Brown

3

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21 August 2017

Colin M Stack

5

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21 August 2017

James S McCarthy

6

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21 August 2017

John P Dalton

7

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21 August 2017

Katharine R Trenholme

8

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21 August 2017

1 November 2009

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Expert Review of Anti-infective Therapy

21 August 2017

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21 August 2017

7

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21 August 2017

9

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21 August 2017

1087-1098

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Epidemiology. Lower malaria numbers reflect better estimates and a glimmer of hope

21 August 2017

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Malaria parasite burden and treatment seeking behavior in ethnic communities of Assam, Northeastern India

21 January 2018

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Malaria in pregnancy and the endemicity spectrum: what can we learn?

21 January 2018

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Plasmodium vivax: who cares?

21 January 2018

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Malaria in the post-genomics era: light at the end of the tunnel or just another train?

21 January 2018

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Clinical pharmacology of artemisinin-based combination therapies

21 January 2018

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Parasitological rebound effect and emergence of pyrimethamine resistance in Plasmodium falciparum after single-dose sulfadoxine-pyrimethamine

21 January 2018

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Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia

21 January 2018

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Declining artesunate-mefloquine efficacy against falciparum malaria on the Cambodia-Thailand border

21 January 2018

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Malaria chemotherapeutics part I: History of antimalarial drug development, currently used therapeutics, and drugs in clinical development

21 January 2018

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Medicines for Malaria Venture: sustaining antimalarial drug development

21 January 2018

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Genome sequence of the human malaria parasite Plasmodium falciparum

21 January 2018

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Recent highlights in antimalarial drug resistance and chemotherapy research

21 January 2018

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Novel molecular targets for antimalarial chemotherapy

21 January 2018

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Antimalarial drug discovery: old and new approaches

21 January 2018

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Antimalarial drugs - what is in use and what is in the pipeline

21 January 2018

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ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

21 January 2018

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Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications

21 January 2018

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Molecular cloning and nuclear localization of a histone deacetylase homologue in Plasmodium falciparum

21 January 2018

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Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites

21 January 2018

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Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum

21 January 2018

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Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity

21 January 2018

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PfADA2, a Plasmodium falciparum homologue of the transcriptional coactivator ADA2 and its in vivo association with the histone acetyltransferase PfGCN5.

21 January 2018

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Potent antimalarial activity of histone deacetylase inhibitor analogues.

21 January 2018

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PfGCN5-mediated histone H3 acetylation plays a key role in gene expression in Plasmodium falciparum

21 January 2018

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Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy.

21 January 2018

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Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors

21 January 2018

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Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies

21 January 2018

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Antiretrovirals as antimalarial agents.

21 January 2018

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Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro.

21 January 2018

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Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria

21 January 2018

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Antimalarial activity of sera from subjects taking HIV protease inhibitors.

21 January 2018

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HIV protease inhibitors inhibit the development of preerythrocytic-stage plasmodium parasites.

21 January 2018

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A green fluorescent protein-based assay for determining gametocyte production in Plasmodium falciparum.

21 January 2018

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Stronger activity of human immunodeficiency virus type 1 protease inhibitors against clinical isolates of Plasmodium vivax than against those of P. falciparum.

21 January 2018

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Targeting the HIV-protease in AIDS therapy: a current clinical perspective

21 January 2018

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Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets.

21 January 2018

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The role of Plasmodium falciparum food vacuole plasmepsins

21 January 2018

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Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy

21 January 2018

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Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum.

21 January 2018

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Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine

21 January 2018

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Characterization of plasmepsin V, a membrane-bound aspartic protease homolog in the endoplasmic reticulum of Plasmodium falciparum

21 January 2018

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Virtual ligand screening: strategies, perspectives and limitations

21 January 2018

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Homology modeling in drug discovery: current trends and applications

21 January 2018

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Docking and scoring in virtual screening for drug discovery: methods and applications

21 January 2018

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Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum

21 January 2018

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Active-site specificity of digestive aspartic peptidases from the four species of Plasmodium that infect humans using chromogenic combinatorial peptide libraries

21 January 2018

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Predicting functional residues in Plasmodium falciparum plasmepsins by combining sequence and structural analysis with molecular dynamics simulations.

21 January 2018

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High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor

21 January 2018

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Properties and substrate specificity of a purine phosphoribosyltransferase from the human malaria parasite, Plasmodium falciparum.

21 January 2018

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Purification and characterization of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase and comparison with the human enzyme.

21 January 2018

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The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor

21 January 2018

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The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor

21 January 2018

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Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics

21 January 2018

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Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo

21 January 2018

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Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity

21 January 2018

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Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development

21 January 2018

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Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

21 January 2018

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Leucine aminopeptidases: diversity in structure and function

21 January 2018

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Transport of the essential nutrient isoleucine in human erythrocytes infected with the malaria parasite Plasmodium falciparum.

21 January 2018

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Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems

21 January 2018

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The role of aminopeptidases in haemoglobin degradation in Plasmodium falciparum-infected erythrocytes

21 January 2018

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Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds.

21 January 2018

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The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors.

21 January 2018

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Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin

21 January 2018

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Characterisation of Aspergillus niger prolyl aminopeptidase

21 January 2018

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Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase

21 January 2018

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Identification of yeast aspartyl aminopeptidase gene by purifying and characterizing its product from yeast cells

21 January 2018

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The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.

21 January 2018

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Construction and use of Plasmodium falciparum phage display libraries to identify host parasite interactions

21 January 2018

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Targeting malaria virulence and remodeling proteins to the host erythrocyte

21 January 2018

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A host-targeting signal in virulence proteins reveals a secretome in malarial infection

21 January 2018

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Histone deacetylase inhibitors in cancer therapy

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/ERI.09.93

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21 August 2017

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