MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE. (Q37630543)

21 August 2017

1 reference

title

MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE. (English)

1 reference

21 August 2017

Luciano Domenici

3

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Ottavio Arancio

object named as

Ottavio Arancio

series ordinal

2

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author name string

Nicola Origlia

series ordinal

1

1 reference

PubMed ID

19903023

21 August 2017

Shirley ShiDu Yan

series ordinal

4

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21 August 2017

1 November 2009

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Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders

21 August 2017

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21 August 2017

9

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21 August 2017

11

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21 August 2017

1635-1645

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Epsilon-secretase: reduction of amyloid precursor protein epsilon-site cleavage in Alzheimer's disease

21 August 2017

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Structure and morphology of the Alzheimer's amyloid fibril

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Neuropsychology--dementia and affective disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Pharmaceutical treatment for cognitive deficits in Alzheimer's disease and other neurodegenerative conditions: exploring new territory using traditional tools and established maps

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Alzheimer's disease is a synaptic failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Perineuronal satellitosis in the human hippocampal formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Functional neuroanatomy of the medial temporal lobe memory system

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain Sections

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

A synaptic model of memory: long-term potentiation in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Learning induces long-term potentiation in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Amyloid beta prevents activation of calcium/calmodulin-dependent protein kinase II and AMPA receptor phosphorylation during hippocampal long-term potentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Regulation of NMDA receptor trafficking by amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

beta-Amyloid peptides impair PKC-dependent functions of metabotropic glutamate receptors in prefrontal cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Amyloid beta-peptide Abeta(1-42) but not Abeta(1-40) attenuates synaptic AMPA receptor function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

The biology of the receptor for advanced glycation end products and its ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Requirement for p38 and p44/p42 mitogen-activated protein kinases in RAGE-mediated nuclear factor-kappaB transcriptional activation and cytokine secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Advanced glycation end products induce tubular epithelial-myofibroblast transition through the RAGE-ERK1/2 MAP kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Receptor for Advanced Glycation Endproducts (RAGE): a formidable force in the pathogenesis of the cardiovascular complications of diabetes & aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

The receptor for advanced glycation end-products (RAGE) directly binds to ERK by a D-domain-like docking site

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Age associated changes of AGE-receptor expression: RAGE upregulation is associated with human heart dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Evaluation of rage isoforms, ligands, and signaling in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

RAGE and amyloid beta interactions: atomic force microscopy and molecular modeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

MAPK cascade signalling and synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Dynamic regulation of ERK2 nuclear translocation and mobility in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

The N-terminal domain of ERK1 accounts for the functional differences with ERK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Role of MAPKs in development and differentiation: lessons from knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Mitogen-activated protein kinases in synaptic plasticity and memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Molecular and cellular mechanisms underlying the cognitive deficits associated with neurofibromatosis 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Requirement of ERK activation for visual cortical plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Activation of p42 mitogen-activated protein kinase in hippocampal long term potentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Ras and Rap control AMPA receptor trafficking during synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Astroglial activation of extracellular-regulated kinase in early stages of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

A death-promoting role for extracellular signal-regulated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Site-specific blockade of RAGE-Vd prevents amyloid-beta oligomer neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

p38 MAP-kinases pathway regulation, function and role in human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

P38 activation mediates amyloid-beta cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

The P38 mitogen-activated protein kinase inhibitor SB203580 antagonizes the inhibitory effects of interleukin-1beta on long-term potentiation in the rat dentate gyrus in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1 beta on long term potentiation in rat dentate gyrus

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activate

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Phosphorylation of c-jun mediated by MAP kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Impaired long-term potentiation in c-Jun N-terminal kinase 2-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Human c-Jun N-terminal kinase expression and activation in the nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

JNK and p38 stresskinases--degenerative effectors of signal-transduction-cascades in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

A role for c-Jun N-terminal kinase in the inhibition of long-term potentiation by interleukin-1beta and long-term depression in the rat dentate gyrus in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

JNK1 contributes to metabotropic glutamate receptor-dependent long-term depression and short-term synaptic plasticity in the mice area hippocampal CA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Morphological criteria for the recognition of Alzheimer's disease and the distribution pattern of cortical changes related to this disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

JNK activation is associated with intracellular beta-amyloid accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-beta on long term potentiation and cell death in hippocampus: a role for interleukin-1beta?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

MAPK recruitment by beta-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

JNK1 Is Required for Maintenance of Neuronal Microtubules and Controls Phosphorylation of Microtubule-Associated Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Regeneration in a degenerating brain: potential of allopregnanolone as a neuroregenerative agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

At the frontline of Alzheimer's disease treatment: gamma-secretase inhibitor/modulator mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Development of vaccination approaches for the treatment of neurological diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Beta-amyloid monomers are neuroprotective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Mechanisms of the inhibitory effects of amyloid beta-protein on synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Activation of MKK6, an upstream activator of p38, in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

p38 kinase is activated in the Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

P38 MAP kinase is activated at early stages in Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERN.09.107

21 January 2018

Identifiers

DOI

10.1586/ERN.09.107

1 reference

21 August 2017

1 reference

PubMed ID

19903023