Steroidal triterpenes: design of substrate-based inhibitors of ergosterol and sitosterol synthesis. (Q37634948)

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12 February 2020

review article

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20 August 2020

Steroidal triterpenes: design of substrate-based inhibitors of ergosterol and sitosterol synthesis (English)

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20 August 2020

Jialin Liu

1

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12 February 2020

William David Nes

series ordinal

2

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language of work or name

English

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publication date

18 November 2009

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12 February 2020

20 August 2020

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12 February 2020

page(s)

4690-4706

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issue

11

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Creative Commons Attribution

12 February 2020

copyright license

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20 August 2020

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Substrate-based inhibitors of the (S)-adenosyl-L-methionine:delta24(25)- to delta24(28)-sterol methyl transferase from Saccharomyces cerevisiae

1 reference

12 December 2020

Ergosterol biosynthesis and drug development for Chagas disease

1 reference

12 December 2020

Azasteroids as antifungals

1 reference

12 December 2020

Inhibition of S-adenosyl-L-methionine sterol-C-24-methyltransferase by analogues of a carbocationic ion high-energy intermediate. Structure activity relationships for C-25 heteroatoms (N, As, S) substituted triterpenoid derivatives.

1 reference

12 December 2020

Cloning, functional expression and phylogenetic analysis of plant sterol 24C-methyltransferases involved in sitosterol biosynthesis

1 reference

12 December 2020

Enzyme Mechanisms for Polycyclic Triterpene Formation

1 reference

12 December 2020

Mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in Trypanosoma brucei

1 reference

12 December 2020

Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii

1 reference

12 December 2020

Preparation of transition-state analogues of sterol 24-methyl transferase as potential anti-parasitics.

1 reference

12 December 2020

Photoaffinity labeling and mutational analysis of 24-C-sterol methyltransferase defines the AdoMet binding site

1 reference

12 December 2020

Sterol methyltransferase: functional analysis of highly conserved residues by site-directed mutagenesis

1 reference

12 December 2020

Structural requirements for transformation of substrates by the S-adenosyl-L-methionine:delta 24(25)-sterol methyltransferase. Inhibition by analogs of the transition state coordinate

1 reference

12 December 2020

Disruption of ergosterol biosynthesis, growth, and the morphological transition in Candida albicans by sterol methyltransferase inhibitors containing sulfur at C-25 in the sterol side chain.

1 reference

12 December 2020

Probing the sterol binding site of soybean sterol methyltransferase by site-directed mutagenesis: functional analysis of conserved aromatic amino acids in Region 1.

1 reference

12 December 2020

Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa

1 reference

12 December 2020

Evaluation of azasterols as anti-parasitics.

1 reference

12 December 2020

Squalene-hopene cyclase: catalytic mechanism and substrate recognition

1 reference

12 December 2020

Biosynthesis of phytosterols. Kinetic mechanism for the enzymatic C-methylation of sterols

1 reference

12 December 2020

Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.

1 reference

12 December 2020

Overexpression, purification, and stereochemical studies of the recombinant (S)-adenosyl-L-methionine: delta 24(25)- to delta 24(28)-sterol methyl transferase enzyme from Saccharomyces cerevisiae

1 reference

12 December 2020

Mechanism and structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase from Saccharomyces cerevisiae

1 reference

12 December 2020

Azasterol inhibition of delta 24-sterol methyltransferase in Saccharomyces cerevisiae

1 reference

12 December 2020

Mechanism and inhibition of delta 24-sterol methyltransferase from Candida albicans and Candida tropicalis

1 reference

12 December 2020

Sterol C24-methyltransferase: mechanistic studies of the C-methylation reaction with 24-fluorocycloartenol

1 reference

12 December 2020

Design and synthesis of potential inhibitors of the ergosterol biosynthesis as antifungal agents

1 reference

12 December 2020

Active site mapping and substrate channeling in the sterol methyltransferase pathway

1 reference

12 December 2020

Modification of the sterol composition of Trypanosoma (Schizotrypanum) cruzi epimastigotes by delta 24(25)-sterol methyl transferase inhibitors and their combinations with ketoconazole

1 reference

12 December 2020

Inhibitors of ergosterol biosynthesis and growth of the trypanosomatid protozoan Crithidia fasciculata

1 reference

12 December 2020

Stereochemistry of yeast delta 24-sterol methyl transferase

1 reference

12 December 2020

Inactivation of soybean sterol 24-C-methyltransferase by elongated sterol side chains at C26

1 reference

12 December 2020

Yeast sterol C24-methyltransferase: role of highly conserved tyrosine-81 in catalytic competence studied by site-directed mutagenesis and thermodynamic analysis

1 reference

12 December 2020

Sterol biosynthesis in Pneumocystis: unique steps that define unique targets

1 reference

12 December 2020

Sterol 24-C-methyltransferase: an enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans

1 reference

12 December 2020

Biosynthesis and accumulation of sterols

1 reference

12 December 2020

Cyclobranol: a substrate for C25-methyl sterol side chains and potent mechanism-based inactivator of plant sterol methyltransferase

1 reference

12 December 2020

Sterol C-methyl transferase from Prototheca wickerhamii mechanism, sterol specificity and inhibition

1 reference

12 December 2020

Sterol specificity of the Saccharomyces cerevisiae ERG6 gene product expressed in Escherichia coli

1 reference

12 December 2020

Cholesterol import fails to prevent catalyst-based inhibition of ergosterol synthesis and cell proliferation of Trypanosoma brucei.

1 reference

12 December 2020

Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs

1 reference

12 December 2020

S-Adenosyl-L-methionine inhibitors delta(24)-sterol methyltransferase and delta(24(28))-sterol methylreductase as possible agents against Paracoccidioides brasiliensis

1 reference

12 December 2020

Sterol biosynthesis inhibitors: potential for transition state analogs and mechanism-based inactivators targeted at sterol methyltransferase

1 reference

12 December 2020

Molecular probing of the Saccharomyces cerevisiae sterol 24-C methyltransferase reveals multiple amino acid residues involved with C2-transfer activity

1 reference

12 December 2020

Synthesis, specificity, and antifungal activity of inhibitors of the Candida albicans delta 24-sterol methyltransferase

1 reference

12 December 2020

Enzyme mechanisms for sterol C-methylations

1 reference

12 December 2020

Mechanism-based enzyme inactivators of phytosterol biosynthesis

1 reference

12 December 2020

Sterol composition of yeast organelle membranes and subcellular distribution of enzymes involved in sterol metabolism

1 reference

12 December 2020

10.3390/MOLECULES14114690

Identifiers

DOI

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release_qfrtu2kmmzg53er3hw47nakedm

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19924096%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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