Pharmacogenetics of membrane transporters: an update on current approaches (Q37641869)

30 June 2019

review article

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title

Pharmacogenetics of membrane transporters: an update on current approaches (English)

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30 June 2019

William Douglas Figg, Sr.

author

6

object named as

William D Figg

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30 June 2019

Tristan M Sissung

1

object named as

Tristan M Sissung

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30 June 2019

author name string

Caitlin E Baum

2

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30 June 2019

C Tyler Kirkland

3

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30 June 2019

Rui Gao

4

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30 June 2019

Erin R Gardner

5

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30 June 2019

publication date

1 February 2010

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30 June 2019

published in

Molecular Biotechnology

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30 June 2019

volume

44

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30 June 2019

issue

2

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30 June 2019

page(s)

152-167

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30 June 2019

Human ATP-binding cassette (ABC) transporter family

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Expression and localization of P-glycoprotein in human heart: effects of cardiomyopathy.

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Digoxin pharmacokinetics and MDR1 genetic polymorphisms

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Dexamethasone as a probe for docetaxel clearance.

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Functional analysis of SNPs variants of BCRP/ABCG2.

21 January 2018

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12 December 2020

ABC multidrug transporters: structure, function and role in chemoresistance.

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12 December 2020

Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropenia

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12 December 2020

Single nucleotide polymorphisms modify the transporter activity of ABCG2.

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12 December 2020

Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17.

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12 December 2020

Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers

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12 December 2020

Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8).

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12 December 2020

Re-evaluation and functional classification of non-synonymous single nucleotide polymorphisms of the human ATP-binding cassette transporter ABCG2.

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12 December 2020

Clinical aspects of the MDR1 (ABCB1) gene polymorphism

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12 December 2020

ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.

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12 December 2020

Single nucleotide polymorphisms and outcome in docetaxel-cisplatin-treated advanced non-small-cell lung cancer

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12 December 2020

BCRP transports dipyridamole and is inhibited by calcium channel blockers

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12 December 2020

The effect of P-glycoprotein on paclitaxel brain and brain tumor distribution in mice.

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12 December 2020

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein.

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12 December 2020

Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies

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12 December 2020

Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance

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12 December 2020

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

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12 December 2020

Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participants

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12 December 2020

In-vitro transport characteristics discriminate wild-type ABCB1 (MDR1) from ALA893SER and ALA893THR polymorphisms

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12 December 2020

Transporters and drug therapy: implications for drug disposition and disease

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12 December 2020

Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination

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12 December 2020

The human ATP-binding cassette (ABC) transporter superfamily

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12 December 2020

Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier

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12 December 2020

Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.

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12 December 2020

Biomarkers in Drug Discovery and Development: From Target Identification through Drug Marketing

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12 December 2020

Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis

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12 December 2020

Overview: ABC transporters and human disease

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12 December 2020

Role of P-glycoprotein in pharmacokinetics: clinical implications

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12 December 2020

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

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12 December 2020

Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer

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12 December 2020

Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans

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12 December 2020

P-glycoprotein-based drug-drug interactions: preclinical methods and relevance to clinical observations

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12 December 2020

C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance.

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12 December 2020

The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model

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12 December 2020

Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms.

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12 December 2020

Variants in the SLCO1B3 gene: interethnic distribution and association with paclitaxel pharmacokinetics.

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12 December 2020

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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12 December 2020

G2677T and C3435T Genotype and Haplotype Are Associated With HepaticABCB1(MDR1) Expression

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12 December 2020

Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2.

1 reference

12 December 2020

Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.

1 reference

12 December 2020

Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain

1 reference

12 December 2020

A family of drug transporters: the multidrug resistance-associated proteins.

1 reference

12 December 2020

The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid (PF-407288) in mice

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12 December 2020

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

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12 December 2020

Effect of ABCG2 genotype on the oral bioavailability of topotecan

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12 December 2020

Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs.

1 reference

12 December 2020

Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel

1 reference

12 December 2020

A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter

1 reference

12 December 2020

Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus

1 reference

12 December 2020

The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin

1 reference

12 December 2020

Modulation of oral bioavailability of anticancer drugs: from mouse to man.

1 reference

12 December 2020

Higher plasma drug concentration in clozapine-treated schizophrenic patients with side effects of obsessive/compulsive symptoms

1 reference

12 December 2020

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

1 reference

12 December 2020

Functional characterization of non-synonymous single nucleotide polymorphisms in the gene encoding human multidrug resistance protein 1 (MRP1/ABCC1).

1 reference

12 December 2020

A mutation hot spot in the Bcrp1 (Abcg2) multidrug transporter in mouse cell lines selected for Doxorubicin resistance

1 reference

12 December 2020

Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene

1 reference

12 December 2020

Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.

1 reference

12 December 2020

Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine.

1 reference

12 December 2020

Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C).

1 reference

12 December 2020

Identification of functionally variant MDR1 alleles among European Americans and African Americans

1 reference

12 December 2020

Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system.

1 reference

12 December 2020

Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima

1 reference

12 December 2020

A "silent" polymorphism in the MDR1 gene changes substrate specificity

1 reference

12 December 2020

High-speed screening of human ATP-binding cassette transporter function and genetic polymorphisms: new strategies in pharmacogenomics.

1 reference

12 December 2020

The Affymetrix DMET platform and pharmacogenetics in drug development

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12 December 2020

Multidrug resistance P-glycoprotein: crucial significance in drug disposition and interaction.

1 reference

12 December 2020

Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma

1 reference

12 December 2020

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

1 reference

12 December 2020

Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity

1 reference

12 December 2020

Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene

1 reference

12 December 2020

Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability

1 reference

12 December 2020

Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib

1 reference

12 December 2020

The multidrug resistance protein family.

1 reference

12 December 2020

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

1 reference

12 December 2020

Pheophorbide a is a specific probe for ABCG2 function and inhibition.

1 reference

12 December 2020

Frequency of MRP1 genetic polymorphisms and their functional significance in Caucasians: detection of a novel mutation G816A in the human MRP1 gene

1 reference

12 December 2020

Flavonoids as a novel class of human organic anion-transporting polypeptide OATP1B1 (OATP-C) modulators

1 reference

12 December 2020

ABCG2 pharmacogenetics: ethnic differences in allele frequency and assessment of influence on irinotecan disposition

1 reference

12 December 2020

Comparison of SLCO1B1 sequence variability among German, Turkish, and African populations

1 reference

12 December 2020

Overexpression of OATP1B3 confers apoptotic resistance in colon cancer

1 reference

12 December 2020

The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells

1 reference

12 December 2020

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine

1 reference

12 December 2020

Importance of P-glycoprotein at blood-tissue barriers

1 reference

12 December 2020

Homozygous disruption of the mdrla P-glycoprotein gene affects blood-nerve barrier function in mice administered with neurotoxic drugs

1 reference

12 December 2020

Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity.

1 reference

12 December 2020

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1 reference

12 December 2020

A novel chalcone derivative which acts as a microtubule depolymerising agent and an inhibitor of P-gp and BCRP in in-vitro and in-vivo glioblastoma models

1 reference

12 December 2020

MDR1 genotype-related pharmacokinetics: fact or fiction?

1 reference

12 December 2020

A variant 2677A allele of the MDR1 gene affects fexofenadine disposition.

1 reference

12 December 2020

Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

1 reference

12 December 2020

Substrate recognition and transport by multidrug resistance protein 1 (ABCC1).

1 reference

12 December 2020

Single nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2.

1 reference

12 December 2020

Modulation of multidrug resistance P-glycoprotein 1 (ABCB1) expression in human heart by hereditary polymorphisms

1 reference

12 December 2020

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

12 December 2020

Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation

1 reference

12 December 2020

A polymorphism in a transporter of testosterone is a determinant of androgen independence in prostate cancer.

1 reference

12 December 2020

Effect of genetic polymorphism of OATP-C (SLCO1B1) on lipid-lowering response to HMG-CoA reductase inhibitors

1 reference

12 December 2020

Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics

1 reference

12 December 2020

P-glycoprotein interaction with risperidone and 9-OH-risperidone studied in vitro, in knock-out mice and in drug-drug interaction experiments

1 reference

12 December 2020

Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1.

1 reference

12 December 2020

Gefitinib ("Iressa", ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance.

1 reference

12 December 2020

10.1007/S12033-009-9220-6

Identifiers

DOI

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30 June 2019

PMC publication ID

6362991

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30 June 2019

PubMed publication ID

19950006

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30 June 2019