ABC multidrug transporters: structure, function and role in chemoresistance. (Q34586418)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18154452%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

review article

1 reference

title

ABC multidrug transporters: structure, function and role in chemoresistance (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18154452%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

main subject

multiple drug resistance

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18154452%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

author name string

Frances J Sharom

series ordinal

1

1 reference

3 August 2017

1 January 2008

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18154452%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18154452%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18154452%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18154452%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

page(s)

105-127

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18154452%20AND%20SRC:MED&resulttype=core&format=json

The ABC of ABCS: a phylogenetic and functional classification of ABC systems in living organisms

31 December 2019

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Binding of steroid modulators to recombinant cytosolic domain from mouse P-glycoprotein in close proximity to the ATP site.

21 January 2018

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The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein

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The molecular basis of the action of disulfiram as a modulator of the multidrug resistance-linked ATP binding cassette transporters MDR1 (ABCB1) and MRP1 (ABCC1).

21 January 2018

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Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense

21 January 2018

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21 January 2018

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What have we learnt thus far from mice with disrupted P-glycoprotein genes?

21 January 2018

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Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage

21 January 2018

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21 January 2018

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21 January 2018

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Importance of P-glycoprotein at blood-tissue barriers

21 January 2018

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P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo.

21 January 2018

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The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.

21 January 2018

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Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk

21 January 2018

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The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.

21 January 2018

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The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme

21 January 2018

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Insight in eukaryotic ABC transporter function by mutation analysis

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Nucleotide binding to the multidrug resistance P-glycoprotein as studied by ESR spectroscopy

21 January 2018

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21 January 2018

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21 January 2018

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Regulation of function by dimerization through the amino-terminal membrane-spanning domain of human ABCC1/MRP1.

21 January 2018

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Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.

21 January 2018

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FRET analysis indicates that the two ATPase active sites of the P-glycoprotein multidrug transporter are closely associated.

21 January 2018

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Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein

21 January 2018

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The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence

21 January 2018

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21 January 2018

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Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2.

21 January 2018

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Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux.

21 January 2018

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Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

21 January 2018

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Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The drug-binding pocket of the human multidrug resistance P-glycoprotein is accessible to the aqueous medium.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Intrinsic fluorescence of the P-glycoprotein multidrug transporter: sensitivity of tryptophan residues to binding of drugs and nucleotides.

21 January 2018

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21 January 2018

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21 January 2018

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Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein, MRP1 (ABCC1).

21 January 2018

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An inward-facing conformation of a putative metal-chelate-type ABC transporter

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein

21 January 2018

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Implications of ATP-binding cassette transporters for brain pharmacotherapies

21 January 2018

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Drug resistance in brain diseases and the role of drug efflux transporters.

21 January 2018

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P-Glycoprotein, a gatekeeper in the blood-brain barrier

21 January 2018

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Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

21 January 2018

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Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs

21 January 2018

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Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters

21 January 2018

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P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance.

21 January 2018

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Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.

21 January 2018

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ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research.

21 January 2018

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Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

21 January 2018

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Single nucleotide polymorphisms of ABCB1 (MDR1) gene and distinct haplotype profile in a West Black African population

21 January 2018

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21 January 2018

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Genetic polymorphisms of the human MDR1 drug transporter

21 January 2018

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Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance

21 January 2018

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Identification of functionally variant MDR1 alleles among European Americans and African Americans

21 January 2018

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A "silent" polymorphism in the MDR1 gene changes substrate specificity

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Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Quantitative structure--activity relationship analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB1 (P-glycoprotein/MDR1).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein-expressing epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Polymorphisms in the multidrug resistance-1 (MDR1) gene influence the response to atorvastatin treatment in a gender-specific manner

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

The association of common SNPs and haplotypes in the CETP and MDR1 genes with lipids response to fluvastatin in familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

An association study of 43 SNPs in 16 candidate genes with atorvastatin response

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Dual infection with Helicobacter bilis and Helicobacter hepaticus in p-glycoprotein-deficient mdr1a-/- mice results in colitis that progresses to dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

MDR1 Ala893 polymorphism is associated with inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Polymorphism in the P-glycoprotein drug transporter MDR1 gene in colon cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

The anti-Parkinson drug budipine is exported actively out of the brain by P-glycoprotein in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Polymorphisms of MRP1 (ABCC1) and related ATP-dependent drug transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

A functional polymorphism within the MRP1 gene locus identified through its genomic signature of positive selection

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Frequency of MRP1 genetic polymorphisms and their functional significance in Caucasians: detection of a novel mutation G816A in the human MRP1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Functional characterization of non-synonymous single nucleotide polymorphisms in the gene encoding human multidrug resistance protein 1 (MRP1/ABCC1).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Functional and structural consequences of cysteine substitutions in the NH2 proximal region of the human multidrug resistance protein 1 (MRP1/ABCC1).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Functional analysis of SNPs variants of BCRP/ABCG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Single nucleotide polymorphisms modify the transporter activity of ABCG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Single nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Re-evaluation and functional classification of non-synonymous single nucleotide polymorphisms of the human ATP-binding cassette transporter ABCG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

The role of the human ABCG2 multidrug transporter and its variants in cancer therapy and toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

ABCG2 pharmacogenetics: ethnic differences in allele frequency and assessment of influence on irinotecan disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in relation to ABC transporter genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Association of variant ABCG2 and the pharmacokinetics of epidermal growth factor receptor tyrosine kinase inhibitors in cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Association of the BCRP C421A polymorphism with nonpapillary renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

N-Linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

The controversial association of ABCB1 polymorphisms in refractory epilepsy: An analysis of multiple SNPs in an Irish population

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105

Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.105