Protein kinase Calpha: disease regulator and therapeutic target. (Q37647208)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19969380%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

review article

2 references

26 October 2020

Protein kinase Calpha: disease regulator and therapeutic target (English)

1 reference

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13 February 2020

1 reference

28 September 2019

1 reference

26 October 2020

2

1 reference

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13 February 2020

author name string

Olga Konopatskaya

series ordinal

1

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publication date

5 December 2009

1 reference

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Trends in Pharmacological Sciences

13 February 2020

1 January 2010

1 reference

26 October 2020

5 references

25 June 2019

28 September 2019

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1 June 2020

26 October 2020

31

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issue

1

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page(s)

8-14

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

13 February 2020

copyright license

3 references

25 June 2019

28 September 2019

Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach

26 October 2020

cites work

1 reference

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Protein kinase C intervention: the state of play

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Protein kinase C in heart failure: a therapeutic target?

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PKCalpha regulates platelet granule secretion and thrombus formation in mice

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23 August 2017

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PKC isozymes in chronic cardiac disease: possible therapeutic targets?

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Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer

23 August 2017

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The role of protein kinase C activation and the vascular complications of diabetes

23 August 2017

1 reference

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Clinical aspects of platelet inhibitors and thrombus formation

23 August 2017

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Phase III study of gemcitabine and cisplatin with or without aprinocarsen, a protein kinase C-alpha antisense oligonucleotide, in patients with advanced-stage non-small-cell lung cancer

23 August 2017

1 reference

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The role of protein kinase C-alpha in hematologic malignancies

23 August 2017

1 reference

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Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression

23 August 2017

1 reference

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A phase II trial of ISIS 3521 in patients with metastatic colorectal cancer

23 August 2017

1 reference

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Protein kinase C alpha expression in breast and ovarian cancer

23 August 2017

1 reference

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A phase I/II study of LY900003, an antisense inhibitor of protein kinase C-alpha, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer

23 August 2017

1 reference

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PKC-interacting proteins: from function to pharmacology

23 August 2017

1 reference

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Phase II study of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C alpha, in patients with previously treated low-grade non-Hodgkin's lymphoma

23 August 2017

1 reference

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The role of protein kinase C-alpha (PKC-alpha) in cancer and its modulation by the novel PKC-alpha-specific inhibitor aprinocarsen

23 August 2017

1 reference

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Lactosylceramide recruits PKCalpha/epsilon and phospholipase A2 to stimulate PECAM-1 expression in human monocytes and adhesion to endothelial cells

23 August 2017

1 reference

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PKC-alpha regulates cardiac contractility and propensity toward heart failure

23 August 2017

1 reference

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23 August 2017

1 reference

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Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T

23 August 2017

1 reference

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Role of Ca2+ signaling in the regulation of endothelial permeability

23 August 2017

1 reference

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Direct Demonstration of Involvement of Protein Kinase Cα in the Ca2+-induced Platelet Aggregation

23 August 2017

1 reference

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Antisense therapy directed to protein kinase C-alpha (affinitak, LY900003/ISIS 3521): Potential role in breast cancer

23 August 2017

1 reference

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Protein kinase C alpha (PKC alpha): regulation and biological function

23 August 2017

1 reference

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Knockout of PKC alpha enhances insulin signaling through PI3K

23 August 2017

1 reference

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Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo

23 August 2017

1 reference

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23 August 2017

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PKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2)

23 August 2017

1 reference

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Protein kinase C inhibitors as novel anticancer drugs

23 August 2017

1 reference

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High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells

23 August 2017

1 reference

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Ca(2+) signalling and PKCalpha activate increased endothelial permeability by disassembly of VE-cadherin junctions

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Protein kinase C isozymes and the regulation of diverse cell responses

23 August 2017

1 reference

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Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth

23 August 2017

1 reference

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Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

SDF-1-induced adhesion of monocytes to vascular endothelium is modulated by azelnidipine via protein kinase C inhibition

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Apolipoprotein CIII-induced THP-1 cell adhesion to endothelial cells involves pertussis toxin-sensitive G protein- and protein kinase C alpha-mediated nuclear factor-kappaB activation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Protein kinase C (PKC) alpha and PKC theta are the major PKC isotypes involved in TCR down-regulation

14 September 2017

1 reference

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Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors

14 September 2017

1 reference

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Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells

14 September 2017

1 reference

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Identification of PKCalpha isoform-specific effects in cardiac myocytes using antisense phosphorothioate oligonucleotides

14 September 2017

1 reference

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Role of oxidized low density lipoprotein in atherogenesis

14 September 2017

1 reference

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Patterns of protein kinase C isoenzyme expression in transitional cell carcinoma of bladder. Relation to degree of malignancy

14 September 2017

1 reference

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Endothelial proliferation, migration, and differentiation are blunted by conditionally expressed protein kinase C pseudosubstrate peptides

28 September 2017

1 reference

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Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells

28 September 2017

1 reference

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Loss of protein kinase Calpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma

25 June 2018

1 reference

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Binding of elements of protein kinase C-alpha regulatory domain to lamin B1.

25 June 2018

1 reference

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Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts

25 June 2018

1 reference

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Chelerythrine is a potent and specific inhibitor of protein kinase C.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Inhibition of protein kinase C by calphostin C is light-dependent

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction.

1 September 2018

1 reference

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Targeting the protein kinase C family: are we there yet?

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

1 September 2018

1 reference

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Protein kinase Calpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCalpha

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Functional interaction of protein kinase Calpha with the tyrosine kinases Syk and Src in human platelets.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Tumor grade-dependent alterations in the protein kinase C isoform pattern in urinary bladder carcinomas

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Protein kinase C-alpha-induced hypertrophy of neonatal rat ventricular myocytes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Immunohistochemical analysis of advanced human breast carcinomas reveals downregulation of protein kinase C alpha

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

A Phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C alpha, administered as a 21-day infusion to patients with advanced ovarian carcinoma.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Molecular characterization of protein kinase C-alpha binding to lamin A.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunction

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Identification of protein kinase Calpha as an essential, but not sufficient, cytosolic factor for Ca2+-induced alpha- and dense-core granule secretion in platelets

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

Protein kinase C-alpha mediates endothelial barrier dysfunction induced by TNF-alpha.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809215

1 September 2018

1 reference

12 December 2020

Regulation of vascular endothelial barrier function

1 reference

12 December 2020

High glucose concentrations increase endothelial cell permeability via activation of protein kinase C alpha

1 reference

12 December 2020

Defective IgG2a/2b class switching in PKC alpha-/- mice

1 reference

12 December 2020

Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice

1 reference

12 December 2020

Interleukin-1beta increases expression and activity of matrix metalloproteinase-2 in cardiac microvascular endothelial cells: role of PKCalpha/beta1 and MAPKs

1 reference

12 December 2020

Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure

1 reference

12 December 2020

A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer

1 reference

12 December 2020

Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate

1 reference

12 December 2020

10.1016/J.TIPS.2009.10.006

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19969380%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19969380%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference