The role of metabolic biomarkers in drug toxicity studies (Q37658689)

21 August 2017

The role of metabolic biomarkers in drug toxicity studies (English)

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21 August 2017

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Laura K Schnackenberg

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1

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PubMed ID

20020895

21 August 2017

Richard D Beger

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2

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PubMed ID

20020895

21 August 2017

language of work or name

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1 January 2008

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Toxicology Mechanisms and Methods

21 August 2017

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21 August 2017

18

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21 August 2017

301-311

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21 August 2017

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Troponin as a marker of myocardiac damage in drug-induced cardiotoxicity.

21 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Serum transaminase elevations as indicators of hepatic injury following the administration of drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Classification of toxin-induced changes in 1H NMR spectra of urine using an artificial neural network.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Metabolic trajectory characterisation of xenobiotic-induced hepatotoxic lesions using statistical batch processing of NMR data

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Chemometric analysis of biofluids following toxicant induced hepatotoxicity: a metabonomic approach to distinguish the effects of 1-naphthylisothiocyanate from its products

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Molecular profiling approaches for identifying novel biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

The role of quantitative neurological examination in clinical neurotoxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Pharmaco-metabonomic phenotyping and personalized drug treatment

21 January 2018

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https://api.crossref.org/works/10.1080%2F15376510701623193

An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: application in metabonomic toxicology studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Suppressive effect of corn bran hemicellulose on liver injury induced by D-galactosamine in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Protein kinase C epsilon signaling complexes include metabolism- and transcription/translation-related proteins: complimentary separation techniques with LC/MS/MS

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

The utility of a rodent model in detecting pediatric drug-induced nephrotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Metabolomics – the link between genotypes and phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Establishing reporting standards for metabolomic and metabonomic studies: a call for participation

21 January 2018

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https://api.crossref.org/works/10.1080%2F15376510701623193

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Integrated metabonomic analysis of the multiorgan effects of hydrazine toxicity in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Cellular environment of metabolites and a metabonomic study of tamoxifen in endometrial cells using gradient high resolution magic angle spinning 1H NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Monitoring diet effects via biofluids and their implications for metabolomics studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

The application of NMR-based metabonomics in neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Drug-induced liver disorders: implications for drug development and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Idiosyncratic drug hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Metabonomic modeling of drug toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Analytical reproducibility in (1)H NMR-based metabonomic urinalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Cyclosporin A-induced changes in endogenous metabolites in rat urine: a metabonomic investigation using high field 1H NMR spectroscopy, HPLC-TOF/MS and chemometrics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

A metabonomic investigation of the biochemical effects of mercuric chloride in the rat using 1H NMR and HPLC-TOF/MS: time dependent changes in the urinary profile of endogenous metabolites as a result of nephrotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Metabonomics with 1H-NMR spectroscopy and liquid chromatography-mass spectrometry applied to the investigation of metabolic changes caused by gentamicin-induced nephrotoxicity in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Analytical strategies in metabonomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Urinary metabolites and antioxidant products of exogenous melatonin in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Proton nuclear magnetic resonance spectroscopy of body fluids in the field of inborn errors of metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of a drug-induced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Metabonomics: a platform for studying drug toxicity and gene function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Gut microorganisms, mammalian metabolism and personalized health care

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Metabolomic study of cisplatin-induced nephrotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

21 January 2018

NMR-based metabolomics

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https://api.crossref.org/works/10.1080%2F15376510701623193

Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Metabonomic assessment of vasculitis in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Metabonomics in toxicology: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

An integrated study of acute effects of valproic acid in the liver using metabonomics, proteomics, and transcriptomics platforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Melatonin protects against gentamicin-induced nephrotoxicity in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics of the blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Mechanistic biomarkers for cytotoxic acute kidney injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

The toxicological significance of decreased activities of blood alanine and aspartate aminotransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

NMR and pattern recognition studies on the time-related metabolic effects of alpha-naphthylisothiocyanate on liver, urine, and plasma in the rat: an integrative metabonomic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

1H NMR Pattern Recognition and 31P NMR Studies with d-Serine in Rat Urine and Kidney, Time- and Dose-Related Metabolic Effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

An integrated metabonomic approach to describe temporal metabolic disregulation induced in the rat by the model hepatotoxin allyl formate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Evolution of intrahepatic carbon, nitrogen, and energy metabolism in a D-galactosamine-induced rat liver failure model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Mechanisms and biomarkers of cardiovascular injury induced by phosphodiesterase inhibitor III SK&F 95654 in the spontaneously hypertensive rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Summary recommendations for standardization and reporting of metabolic analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Earthworm species of the genus Eisenia can be phenotypically differentiated by metabolic profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Metabolomics: Current analytical platforms and methodologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Studies on the comparative toxicity of S-(1,2-dichlorovinyl)-L-cysteine, S-(1,2-dichlorovinyl)-L-homocysteine and 1,1,2-trichloro-3,3,3-trifluoro-1-propene in the Fischer 344 rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Batch statistical processing of1H NMR-derived urinary spectral data

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Nuclear Magnetic Resonance Spectroscopic and Principal Components Analysis Investigations into Biochemical Effects of Three Model Hepatotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Assessment of Analytical Reproducibility of1H NMR Spectroscopy Based Metabonomics for Large-Scale Epidemiological Research: the INTERMAP Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Toxicity classification from metabonomic data using a density superposition approach: ‘CLOUDS’

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

A1H NMR spectroscopic study of the biochemical effects of ifosfamide in the rat: evaluation of potential biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

UPLC/MSE; a new approach for generating molecular fragment information for biomarker structure elucidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15376510701623193

Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles

21 January 2018

1 reference

5 May 2024

https://opencitations.net/index/api/v1/citations/10.1021/TX034212W

Identifiers

DOI

10.1080/15376510701623193

1 reference

21 August 2017

1 reference

PubMed ID

20020895