Human copper homeostasis: a network of interconnected pathways. (Q37684520)

22 August 2017

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title

Human copper homeostasis: a network of interconnected pathways (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6365103&resulttype=core&format=json

13 May 2020

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Svetlana Lutsenko

1

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13 May 2020

publication date

1 February 2010

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Current Opinion in Chemical Biology

22 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6365103&resulttype=core&format=json

13 May 2020

volume

14

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6365103&resulttype=core&format=json

13 May 2020

issue

2

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13 May 2020

page(s)

211-217

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6365103&resulttype=core&format=json

Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter

13 May 2020

cites work

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12 December 2020

Expression, localisation and hormone regulation of the human copper transporter hCTR1 in placenta and choriocarcinoma Jeg-3 cells

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12 December 2020

Consequences of copper accumulation in the livers of the Atp7b-/- (Wilson disease gene) knockout mice

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12 December 2020

The Steap proteins are metalloreductases

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12 December 2020

Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function

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12 December 2020

Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells.

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12 December 2020

High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease.

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12 December 2020

Identification of a vacuole-associated metalloreductase and its role in Ctr2-mediated intracellular copper mobilization.

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12 December 2020

Altered ATP7A expression and other compensatory responses in a murine model of Menkes disease

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12 December 2020

Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake

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12 December 2020

Human copper transporter hCTR1 mediates basolateral uptake of copper into enterocytes: implications for copper homeostasis

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12 December 2020

Intracellular targeting of copper-transporting ATPase ATP7A in a normal and Atp7b-/- kidney

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12 December 2020

Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells

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12 December 2020

Novel role of antioxidant-1 (Atox1) as a copper-dependent transcription factor involved in cell proliferation

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12 December 2020

Copper transporter 1, metallothionein and glutathione reductase genes are differentially expressed in tissues of sea bream (Sparus aurata) after exposure to dietary or waterborne copper

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12 December 2020

ATP7B copper-regulated traffic and association with the tight junctions: copper excretion into the bile

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12 December 2020

Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer

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12 December 2020

Transcription factor Sp1 plays an important role in the regulation of copper homeostasis in mammalian cells

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12 December 2020

Copper transport during lactation in transgenic mice expressing the human ATP7A protein

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12 December 2020

"Pulling the plug" on cellular copper: the role of mitochondria in copper export

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12 December 2020

Copper is taken up efficiently from albumin and alpha2-macroglobulin by cultured human cells by more than one mechanism

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12 December 2020

Different regulation of wild-type and mutant Cu,Zn superoxide dismutase localization in mammalian mitochondria

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12 December 2020

Knock down of Caenorhabditis elegans cutc-1 exacerbates the sensitivity toward high levels of copper.

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12 December 2020

Structure of the two transmembrane Cu+ transport sites of the Cu+ -ATPases

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12 December 2020

Transcriptional activation in yeast in response to copper deficiency involves copper-zinc superoxide dismutase

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12 December 2020

Regulation of prion gene expression by transcription factors SP1 and metal transcription factor-1.

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12 December 2020

Niemann-Pick C1 protein transports copper to the secretory compartment from late endosomes where ATP7B resides

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12 December 2020

Apical targeting and Golgi retention signals reside within a 9-amino acid sequence in the copper-ATPase, ATP7B.

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12 December 2020

ATM-mediated Transcriptional Elevation of Prion in Response to Copper-induced Oxidative Stress

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12 December 2020

Copper transport systems are involved in multidrug resistance and drug transport

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12 December 2020

Dominant mutants of ceruloplasmin impair the copper loading machinery in aceruloplasminemia.

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12 December 2020

Deletion of hepatic Ctr1 reveals its function in copper acquisition and compensatory mechanisms for copper homeostasis

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12 December 2020

Effects of the loss of Atox1 on the cellular pharmacology of cisplatin

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12 December 2020

The multi-layered regulation of copper translocating P-type ATPases

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12 December 2020

Functional interactions of Cu-ATPase ATP7B with cisplatin and the role of ATP7B in the resistance of cells to the drug

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12 December 2020

The soluble metal-binding domain of the copper transporter ATP7B binds and detoxifies cisplatin

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12 December 2020

Three-dimensional structure of the human copper transporter hCTR1.

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12 December 2020

Human SCO2 is required for the synthesis of CO II and as a thiol-disulphide oxidoreductase for SCO1.

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12 December 2020

Copper transport into the secretory pathway is regulated by oxygen in macrophages

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12 December 2020

Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone, Atox1.

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12 December 2020

Reaction cycle of Thermotoga maritima copper ATPase and conformational characterization of catalytically deficient mutants

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12 December 2020

The loop connecting metal-binding domains 3 and 4 of ATP7B is a target of a kinase-mediated phosphorylation

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12 December 2020

Cell-specific trafficking suggests a new role for renal ATP7B in the intracellular copper storage

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12 December 2020

Therapeutic Targeting of ATP7B in Ovarian Carcinoma.

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12 December 2020

Nucleotide recognition by CopA, a Cu+-transporting P-type ATPase

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12 December 2020

High yield heterologous expression of wild-type and mutant Cu+-ATPase (ATP7B, Wilson disease protein) for functional characterization of catalytic activity and serine residues undergoing copper-dependent phosphorylation

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12 December 2020

Chaperone-mediated Cu+ delivery to Cu+ transport ATPases: requirement of nucleotide binding

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12 December 2020

Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase.

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12 December 2020

Dissecting the role of the N-terminal metal-binding domains in activating the yeast copper ATPase in vivo.

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12 December 2020

Alternative splicing of the Menkes copper Atpase (Atp7a) transcript in the rat intestinal epithelium

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12 December 2020

Influence of estrogens on copper indicators: in vivo and in vitro studies

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12 December 2020

Copper-dependent recycling of hCTR1, the human high affinity copper transporter.

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12 December 2020

Crystal Structures of Cisplatin Bound to a Human Copper Chaperone

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12 December 2020

A role for the ATP7A copper-transporting ATPase in macrophage bactericidal activity

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12 December 2020

Structural biology of copper trafficking

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12 December 2020

Structural organization of human Cu-transporting ATPases: learning from building blocks

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12 December 2020

Human copper transporter Ctr1 is functional in Drosophila, revealing a high degree of conservation between mammals and insects.

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12 December 2020

Copper redistribution in Atox1-deficient mouse fibroblast cells

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12 December 2020

Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site

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12 December 2020

The Binding Mode of ATP Revealed by the Solution Structure of the N-domain of Human ATP7A

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12 December 2020

10.1016/J.CBPA.2010.01.003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6365103&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6365103&resulttype=core&format=json

13 May 2020

1 reference