Deregulated sphingolipid metabolism and membrane organization in neurodegenerative disorders. (Q37686232)

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17 January 2020

review article

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title

Deregulated sphingolipid metabolism and membrane organization in neurodegenerative disorders (English)

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17 January 2020

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17 January 2020

Giovanni DeMarco

9

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17 January 2020

Sandro Sonnino

12

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17 January 2020

Alessandro Prinetti

13

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17 January 2020

author name string

Marco Piccinini

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17 January 2020

Federica Scandroglio

2

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17 January 2020

Simona Prioni

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17 January 2020

Barbara Buccinnà

4

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17 January 2020

Nicoletta Loberto

5

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17 January 2020

Vanna Chigorno

7

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17 January 2020

Elisa Lupino

8

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17 January 2020

Annarosa Lomartire

10

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17 January 2020

Maria Teresa Rinaudo

11

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17 January 2020

publication date

3 February 2010

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17 January 2020

published in

Molecular Neurobiology

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17 January 2020

volume

41

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17 January 2020

issue

2-3

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17 January 2020

page(s)

314-340

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https://scigraph.springernature.com/pub.10.1007/s12035-009-8096-6

17 January 2020

exact match

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Glycosphingolipid Synthesis Inhibitor Represses Cytokine-Induced Activation of the Ras-MAPK Pathway in Embryonic Neural Precursor Cells

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12 December 2020

Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?

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12 December 2020

Cell growth regulation through GM3-enriched microdomain (glycosynapse) in human lung embryonal fibroblast WI38 and its oncogenic transformant VA13.

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12 December 2020

Gaucher disease with parkinsonian manifestations: does glucocerebrosidase deficiency contribute to a vulnerability to parkinsonism?

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12 December 2020

Structural membrane alterations in Alzheimer brains found to be associated with regional disease development; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergent-resistant membrane domains

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12 December 2020

Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets

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The synthetic ceramide analog L-PDMP partially protects striatal dopamine levels but does not promote dopamine neuron survival in murine models of parkinsonism.

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12 December 2020

Guidance on the use of miglustat for treating patients with type 1 Gaucher disease

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12 December 2020

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12 December 2020

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Ganglioside-induced neuritogenesis: verification that gangliosides are the active agents, and comparison of molecular species.

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12 December 2020

Mannose 6-phosphate receptor-mediated uptake is defective in acid sphingomyelinase-deficient macrophages: implications for Niemann-Pick disease enzyme replacement therapy

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12 December 2020

Secretory granule biogenesis: rafting to the SNARE.

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12 December 2020

Regional distribution of brain gangliosides in Alzheimer's disease

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12 December 2020

Developmental changes of glycosphingolipids and expression of glycogenes in mouse brains

1 reference

12 December 2020

Sphingolipid Depletion Increases Formation of the Scrapie Prion Protein in Neuroblastoma Cells Infected with Prions

1 reference

12 December 2020

Influence of glycolipid oligosaccharide and long-chain base composition on the thermotropic properties of dipalmitoylphosphatidylcholine large unilamellar vesicles containing gangliosides

1 reference

12 December 2020

Aggregation properties of GD1b, II3Neu5Ac2GgOse4Cer, and of GD1b-lactone, II3[alpha-Neu5Ac-(2----8, 1----9)-alpha-Neu5Ac]GgOse4Cer, in aqueous solution

1 reference

12 December 2020

Multiple functions of the myelin-associated glycoprotein MAG (siglec-4a) in formation and maintenance of myelin

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12 December 2020

Assembly of myelin by association of proteolipid protein with cholesterol- and galactosylceramide-rich membrane domains

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12 December 2020

The role and metabolism of sulfatide in the nervous system

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12 December 2020

Developmental changes in ganglioside composition and synthesis in embryonic rat brain.

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12 December 2020

Glycosphingolipid-enriched signaling domain in mouse neuroblastoma Neuro2a cells. Mechanism of ganglioside-dependent neuritogenesis

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12 December 2020

Intracellular Location and Properties of Bovine Brain Sialidase

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12 December 2020

Self-association of beta-amyloid peptide (1-40) in solution and binding to lipid membranes.

1 reference

12 December 2020

Neural CAMS and their role in the development and organization of myelin sheaths

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12 December 2020

Enhanced GM1 ganglioside catabolism in cultured fibroblasts from Alzheimer patients

1 reference

12 December 2020

Myelin-associated glycoprotein (MAG): past, present and beyond

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12 December 2020

Sphingomyelinases: enzymology and membrane activity

1 reference

12 December 2020

Changes in the glycolipid composition and characteristic activation of GM3 synthase in the thymus of mouse after administration of dexamethasone.

1 reference

12 December 2020

Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro

1 reference

12 December 2020

Sialic acid specificity of myelin-associated glycoprotein binding

1 reference

12 December 2020

Nerve growth factor, a differentiating agent, and epidermal growth factor, a mitogen, increase the activities of different S6 kinases in PC12 cells

1 reference

12 December 2020

Identification of a family of animal sphingomyelin synthases

1 reference

12 December 2020

Partial characterization and enrichment of a membrane-bound sialidase specific for gangliosides from human brain tissue.

1 reference

12 December 2020

Novel oral treatment of Gaucher's disease with N-butyldeoxynojirimycin (OGT 918) to decrease substrate biosynthesis.

1 reference

12 December 2020

A seed for Alzheimer amyloid in the brain.

1 reference

12 December 2020

Specificity and potential mechanism of sulfatide deficiency in Alzheimer's disease: an electrospray ionization mass spectrometric study

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12 December 2020

Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth

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12 December 2020

Exogenous gangliosides, neuronal plasticity and repair, and the neurotrophins

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12 December 2020

Acceleration of amyloid fibril formation by specific binding of Abeta-(1-40) peptide to ganglioside-containing membrane vesicles

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12 December 2020

COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform

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12 December 2020

Receptors for myelin inhibitors: Structures and therapeutic opportunities

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12 December 2020

Brain gangliosides: functional ligands for myelin stability and the control of nerve regeneration

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12 December 2020

Gel phase preference of ganglioside GM1 at low concentration in two-component, two-phase phosphatidylcholine bilayers depends upon the ceramide moiety

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12 December 2020

Sphingolipid-enriched Membrane Domains from Rat Cerebellar Granule Cells Differentiated in Culture

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12 December 2020

Plasma membrane production of ceramide from ganglioside GM3 in human fibroblasts

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12 December 2020

Ganglioside alterations in guinea pig brains at end stages of experimental Creutzfeldt-Jakob disease

1 reference

12 December 2020

Plasma membrane ganglioside sialidase regulates axonal growth and regeneration in hippocampal neurons in culture.

1 reference

12 December 2020

The plasma membrane-associated sialidase MmNEU3 modifies the ganglioside pattern of adjacent cells supporting its involvement in cell-to-cell interactions.

1 reference

12 December 2020

Association of Src-family protein tyrosine kinases with sphingolipids in rat cerebellar granule cells differentiated in culture

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12 December 2020

Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration

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12 December 2020

A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration

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12 December 2020

Antibodies to ganglioside GM1 in patients with Alzheimer's disease

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12 December 2020

A specific microdomain ("glycosynapse 3") controls phenotypic conversion and reversion of bladder cancer cells through GM3-mediated interaction of alpha3beta1 integrin with CD9.

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12 December 2020

Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia

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12 December 2020

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12 December 2020

GM1 ganglioside-bound amyloid beta-protein in Alzheimer's disease brain.

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12 December 2020

The cytoplasmic domain of the large myelin-associated glycoprotein isoform is needed for proper CNS but not peripheral nervous system myelination

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12 December 2020

A mouse B16 melanoma mutant deficient in glycolipids

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12 December 2020

Type I Gaucher disease, a glycosphingolipid storage disorder, is associated with insulin resistance

1 reference

12 December 2020

Up-regulation of Glucosylceramide Synthesis upon Stimulation of Axonal Growth by Basic Fibroblast Growth Factor

1 reference

12 December 2020

Geometrical and conformational properties of ganglioside GalNAc-GD1a, IV4GalNAcIV3Neu5AcII3Neu5AcGgOse4Cer.

1 reference

12 December 2020

Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture.

1 reference

12 December 2020

Lipid rafts: microenvironments for integrin-growth factor interactions in neural development

1 reference

12 December 2020

Evidence for spontaneous segregation phenomena in mixed micelles of gangliosides

1 reference

12 December 2020

Natural forms of shed tumor gangliosides

1 reference

12 December 2020

Stable transfection of GM1 synthase gene into GM1-deficient NG108-15 cells, CR-72 cells, rescues the responsiveness of Trk-neurotrophin receptor to its ligand, NGF.

1 reference

12 December 2020

Gangliosides turnover and neural cells function: a new perspective.

1 reference

12 December 2020

Role of the beta-amyloid precursor protein in Alzheimer's disease.

1 reference

12 December 2020

Effect of differentiation and cell density on glycosphingolipid class and molecular species composition of mouse neuroblastoma NB2a cells

1 reference

12 December 2020

Suppression of Abeta deposition in brain by peripheral administration of Fab fragments of anti-seed antibody

1 reference

12 December 2020

Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid

1 reference

12 December 2020

When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis

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12 December 2020

Human brain gangliosides in development, aging and disease

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12 December 2020

The fatty acid composition of sphingomyelin from adult human cerebral white matter and changes in childhood, senium and unspecific brain damage

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12 December 2020

Aggregation properties of semisynthetic GD1a ganglioside (IV3Neu5AcII3Neu5AcGgOse4Cer) containing an acetyl group as acyl moiety

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12 December 2020

Reciprocal expression of myelin-associated glycoprotein splice variants in the adult human peripheral and central nervous systems.

1 reference

12 December 2020

New directions in the treatment of Gaucher disease

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12 December 2020

Assembly of hereditary amyloid beta-protein variants in the presence of favorable gangliosides.

1 reference

12 December 2020

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

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12 December 2020

Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation

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12 December 2020

Sphingolipid metabolism and caveolin expression in gonadotropin-releasing hormone-expressing GN11 and gonadotropin-releasing hormone-secreting GT1-7 neuronal cells

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12 December 2020

Low levels of CSF gangliotetraose-series gangliosides in West syndrome: implication of brain maturation disturbance.

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12 December 2020

Three dimensional structure of GD1b and GD1b-monolactone gangliosides in dimethylsulphoxide: a nuclear Overhauser effect investigation supported by molecular dynamics calculations.

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12 December 2020

Calcium/ganglioside-dependent protein kinase activity in rat brain membrane.

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12 December 2020

Ganglioside-modulated protein phosphorylation in muscle. Activation of phosphorylase b kinase by gangliosides

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12 December 2020

Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin.

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12 December 2020

Cloning, expression, and chromosomal mapping of a human ganglioside sialidase

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12 December 2020

Structure of the HNK-1 carbohydrate epitope on bovine peripheral myelin glycoprotein P0

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12 December 2020

Identification of tyrosine 620 as the major phosphorylation site of myelin-associated glycoprotein and its implication in interacting with signaling molecules

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12 December 2020

The Cellular Prion Protein Colocalizes with the Dystroglycan Complex in the Brain

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12 December 2020

1H-NMR study of GM2 ganglioside: evidence that an interresidue amide-carboxyl hydrogen bond contributes to stabilization of a preferred conformation

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12 December 2020

Prevention of lysosomal storage in Tay-Sachs mice treated with N-butyldeoxynojirimycin

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12 December 2020

Ganglioside rafts as MAG receptors that mediate blockade of axon growth

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12 December 2020

Cortical distribution of gangliosides in Alzheimer's disease

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12 December 2020

G-protein coupled receptors in lipid rafts and caveolae: how, when and why do they go there?

1 reference

12 December 2020

Free sphingosine formation from endogenous substrates by a liver plasma membrane system with a divalent cation dependence and a neutral pH optimum

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12 December 2020

Glycosphingolipid deficiency affects functional microdomain formation in Lewis lung carcinoma cells

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12 December 2020

Sphingolipid uptake by cultured cells: complex aggregates of cell sphingolipids with serum proteins and lipoproteins are rapidly catabolized.

1 reference

12 December 2020

Carbohydrate dynamics at a micellar surface: GD1a headgroup transformations revealed by NMR spectroscopy.

1 reference

12 December 2020

Binding of prion proteins to lipid membranes

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12 December 2020

Tyrosine kinase receptors concentrated in caveolae-like domains from neuronal plasma membrane

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12 December 2020

The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease

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12 December 2020

Combinatorial ganglioside biosynthesis

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12 December 2020

Alterations of myelin-specific proteins and sphingolipids characterize the brains of acid sphingomyelinase-deficient mice, an animal model of Niemann-Pick disease type A.

1 reference

12 December 2020

Up-regulation of ganglioside biosynthesis, functional synapse formation, and memory retention by a synthetic ceramide analog (L-PDMP).

1 reference

12 December 2020

Characterization of high-affinity binding between gangliosides and amyloid beta-protein

1 reference

12 December 2020

Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists

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12 December 2020

Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid

1 reference

12 December 2020

Lipid rafts mediate the synaptic localization of alpha-synuclein.

1 reference

12 December 2020

Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth

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12 December 2020

Dynamic and structural properties of sphingolipids as driving forces for the formation of membrane domains.

1 reference

12 December 2020

Gangliosides determine the amyloid pathology of Alzheimer's disease.

1 reference

12 December 2020

The membrane environment of endogenous cellular prion protein in primary rat cerebellar neurons

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12 December 2020

Lipid rafts and the control of neurotrophic factor signaling in the nervous system: variations on a theme

1 reference

12 December 2020

Molecular dissection of the myelin-associated glycoprotein receptor complex reveals cell type-specific mechanisms for neurite outgrowth inhibition

1 reference

12 December 2020

Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a review

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12 December 2020

Toward understanding the dynamics of membrane-raft-based molecular interactions

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12 December 2020

Endosomal accumulation of GM1 ganglioside-bound amyloid beta-protein in neurons of aged monkey brains.

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12 December 2020

Sphingolipids as receptor modulators. An overview

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12 December 2020

GM1 ganglioside restores dopaminergic neurochemical and morphological markers in aged rats.

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12 December 2020

The involvement of lipid rafts in Alzheimer's disease

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12 December 2020

Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease

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12 December 2020

Induction of ganglioside biosynthesis and neurite outgrowth of primary cultured neurons by L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol

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12 December 2020

Solution conformations of GM3 gangliosides containing different sialic acid residues as revealed by NOE-based distance mapping, molecular mechanics, and molecular dynamics calculations

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12 December 2020

The cell biology of lysosomal storage disorders

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12 December 2020

Neuronal polarity: essential role of protein-lipid complexes in axonal sorting

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12 December 2020

Membrane cholesterol content modulates activation of BK channels in colonic epithelia

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12 December 2020

Association of Src family tyrosine kinase Lyn with ganglioside GD3 in rat brain. Possible regulation of Lyn by glycosphingolipid in caveolae-like domains.

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12 December 2020

On the mechanism of internalization of alpha-synuclein into microglia: roles of ganglioside GM1 and lipid raft

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12 December 2020

GM1 ganglioside regulates the proteolysis of amyloid precursor protein

1 reference

12 December 2020

GM1 ganglioside modulates prostaglandin E1 stimulated adenylyl cyclase in neuro-2A cells

1 reference

12 December 2020

Comparison of myelin, axon, lipid, and immunopathology in the central nervous system of differentially myelin-compromised mutant mice: a morphological and biochemical study

1 reference

12 December 2020

Myelin-associated glycoprotein interacts with neurons via a sialic acid binding site at ARG118 and a distinct neurite inhibition site

1 reference

12 December 2020

Parkinson's disease: improved function with GM1 ganglioside treatment in a randomized placebo-controlled study

1 reference

12 December 2020

Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth.

1 reference

12 December 2020

Gangliosides in cultured neurons

1 reference

12 December 2020

Changes in the lipid turnover, composition, and organization, as sphingolipid-enriched membrane domains, in rat cerebellar granule cells developing in vitro

1 reference

12 December 2020

Initial events of myelination involve Fyn tyrosine kinase signalling

1 reference

12 December 2020

Myelin-associated glycoprotein interacts with ganglioside GT1b. A mechanism for neurite outgrowth inhibition

1 reference

12 December 2020

Miglustat. Oxford GlycoSciences/Actelion.

1 reference

12 December 2020

Cholesterol and Alzheimer's disease: statins, cholesterol depletion in APP processing and Abeta generation.

1 reference

12 December 2020

Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance

1 reference

12 December 2020

Effects of cell surface ganglioside sialidase inhibition on growth control and differentiation of human neuroblastoma cells

1 reference

12 December 2020

Physicochemical interactions of amyloid beta-peptide with lipid bilayers

1 reference

12 December 2020

Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice.

1 reference

12 December 2020

Significance of gangliosides in neuronal differentiation of neuroblastoma cells and neurite growth in tissue culture.

1 reference

12 December 2020

Transport of newly synthesized glucosylceramide to the plasma membrane by a non-Golgi pathway

1 reference

12 December 2020

Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes

1 reference

12 December 2020

Promotion of neuritogenesis in mouse neuroblastoma cells by exogenous gangliosides. Relationship between the effect and the cell association of ganglioside GM1.

1 reference

12 December 2020

Aggregation properties of semisynthetic GM1 ganglioside (II3Neu5AcGgOse4Cer) containing an acetyl group as acyl moiety

1 reference

12 December 2020

Ganglioside-modulated protein phosphorylation. Partial purification and characterization of a ganglioside-inhibited protein kinase in brain

1 reference

12 December 2020

Alterations in brain gangliosides and other lipids of patients with Creutzfeldt-Jakob disease and subacute sclerosing panencephalitis (SSPE).

1 reference

12 December 2020

Sulfatide is a negative regulator of oligodendrocyte differentiation: development in sulfatide-null mice

1 reference

12 December 2020

Binding of prion protein to lipid membranes and implications for prion conversion

1 reference

12 December 2020

Changes of mouse brain gangliosides during aging from young adult until senescence

1 reference

12 December 2020

Enzyme replacement in Anderson-Fabry disease

1 reference

12 December 2020

Endogenous glycosphingolipid acceptor specificity of sialosyltransferase systems in intact Golgi membranes, synaptosomes, and synaptic plasma membranes from rat brain

1 reference

12 December 2020

Modulation of cell functions by glycosphingolipid metabolic remodeling in the plasma membrane.

1 reference

12 December 2020

Gene Transfer Strategies for Correction of Lysosomal Storage Disorders

1 reference

12 December 2020

Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid beta-protein fibrillogenesis.

1 reference

12 December 2020

Stimulation of myelin basic protein gene transcription by Fyn tyrosine kinase for myelination.

1 reference

12 December 2020

Lipid rafts and membrane dynamics

1 reference

12 December 2020

GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

1 reference

12 December 2020

Influence of cellular ganglioside depletion on tumor formation

1 reference

12 December 2020

Interactions of proteins with ganglioside-enriched microdomains on the membrane: the lateral phase separation of molecular species of GD1a ganglioside, having homogeneous long-chain base composition, is recognized by Vibrio cholerae sialidase

1 reference

12 December 2020

Effect of nerve growth factor and forskolin on glycosyltransferase activities and expression of a globo-series glycosphingolipid in PC12D pheochromocytoma cells

1 reference

12 December 2020

Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability.

1 reference

12 December 2020

Aggregation properties of GM3 ganglioside (II3Neu5AcLacCer) in aqueous solutions

1 reference

12 December 2020

Ganglioside/glycosphingolipid turnover: new concepts

1 reference

12 December 2020

Parallelism of subcellular location of major particulate neuraminidase and gangliosides in rabbit brain cortex

1 reference

12 December 2020

Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily

1 reference

12 December 2020

Chemistry, metabolism, and biological functions of sialic acids.

1 reference

12 December 2020

Ganglioside alterations in the central and peripheral nervous systems of patients with Creutzfeldt-Jakob disease

1 reference

12 December 2020

Environment- and mutation-dependent aggregation behavior of Alzheimer amyloid beta-protein

1 reference

12 December 2020

Anti-GM1 ganglioside antibodies in Parkinson's disease

1 reference

12 December 2020

Ganglioside GM1 binds to the Trk protein and regulates receptor function

1 reference

12 December 2020

Molecular cloning and characterization of a plasma membrane-associated sialidase specific for gangliosides

1 reference

12 December 2020

Bioactive gangliosides: analysis of functional structures of the tetrasialoganglioside GQ1b which promotes neurite outgrowth.

1 reference

12 December 2020

Synthetic sialyl compounds as well as natural gangliosides induce neuritogenesis in a mouse neuroblastoma cell line (Neuro2a).

1 reference

12 December 2020

Two sphingolipid transfer proteins, CERT and FAPP2: their roles in sphingolipid metabolism

1 reference

12 December 2020

Creutzfeldt-jakob disease — alteration in ganglioside sphingosine in the brain of a patient

1 reference

12 December 2020

Role of gangliosides in Alzheimer's disease

1 reference

12 December 2020

The inhibition site on myelin-associated glycoprotein is within Ig-domain 5 and is distinct from the sialic acid binding site.

1 reference

12 December 2020

Gangliosides inhibit phospholipid-sensitive Ca2+-dependent kinase phosphorylation of rat myelin basic proteins.

1 reference

12 December 2020

Ceramide in rafts (detergent-insoluble fraction) mediates cell death in neurotumor cell lines

1 reference

12 December 2020

Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth.

1 reference

12 December 2020

Possible role of gangliosides in epilepsy: effects of epileptic seizures on cerebral gangliosides

1 reference

12 December 2020

Effects of lipid composition and phase on the membrane interaction of the prion peptide 106-126 amide.

1 reference

12 December 2020

Gangliosides enhance neurite outgrowth in PC12 cells

1 reference

12 December 2020

Dying‐back oligodendrogliopathy: A late sequel of myelin‐associated glycoprotein deficiency

1 reference

12 December 2020

NMR and computational studies of interactions between remote residues in gangliosides

1 reference

12 December 2020

Calcium-dependent interaction between the large myelin-associated glycoprotein and S100beta

1 reference

12 December 2020

The sphingomyelin cycle and the second messenger function of ceramide.

1 reference

12 December 2020

Gangliosides are neuronal ligands for myelin-associated glycoprotein

1 reference

12 December 2020

Miglustat for treatment of Niemann-Pick C disease: a randomised controlled study

1 reference

12 December 2020

Compositional aspects of lipid hydration.

1 reference

12 December 2020

Involvement of gangliosides in glycosylphosphatidylinositol-anchored neuronal cell adhesion molecule TAG-1 signaling in lipid rafts

1 reference

12 December 2020

Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance

1 reference

12 December 2020

Neurotrophic enhancers as therapy for behavioral deficits in rodent models of Huntington's disease: use of gangliosides, substituted pyrimidines, and mesenchymal stem cells

1 reference

12 December 2020

Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis

1 reference

12 December 2020

Occurrence of sialyltransferase activity in the synaptosomal membranes prepared from calf brain cortex

1 reference

12 December 2020

Patterns of endogenous gangliosides and metabolic processing of exogenous gangliosides in cerebellar granule cells during differentiation in culture.

1 reference

12 December 2020

Functional role of glycosphingolipids in cell recognition and signaling

1 reference

12 December 2020

UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum.

1 reference

12 December 2020

Myelination in the absence of myelin-associated glycoprotein

1 reference

12 December 2020

Lipid content of brain, brain membrane lipid domains, and neurons from acid sphingomyelinase deficient mice

1 reference

12 December 2020

Cerebellar granule cells in culture exhibit a ganglioside-sialidase presumably linked to the plasma membrane

1 reference

12 December 2020

Enzyme replacement and enhancement therapies: lessons from lysosomal disorders

1 reference

12 December 2020

Gangliosides as components of lipid membrane domains.

1 reference

12 December 2020

Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes

1 reference

12 December 2020

Immunoseparation of sphingolipid-enriched membrane domains enriched in Src family protein tyrosine kinases and in the neuronal adhesion molecule TAG-1 by anti-GD3 ganglioside monoclonal antibody

1 reference

12 December 2020

The oligodendrocyte and its many cellular processes

1 reference

12 December 2020

Siglecs and their roles in the immune system

1 reference

12 December 2020

Molecular cloning of mouse ganglioside sialidase and its increased expression in Neuro2a cell differentiation.

1 reference

12 December 2020

Tumor gangliosides inhibit the tumor-specific immune response

1 reference

12 December 2020

The small myelin-associated glycoprotein binds to tubulin and microtubules.

1 reference

12 December 2020

Infantile-onset symptomatic epilepsy syndrome caused by a homozygous loss-of-function mutation of GM3 synthase.

1 reference

12 December 2020

Ganglioside stimulation of axonal sprouting in vitro

1 reference

12 December 2020

Correction of mucopolysaccharidosis type IIIb fibroblasts by lentiviral vector-mediated gene transfer

1 reference

12 December 2020

Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis

1 reference

12 December 2020

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

1 reference

12 December 2020

Conformation of the oligosaccharide chain of G(M1) ganglioside in a carbohydrate-enriched surface

1 reference

12 December 2020

Ganglioside metabolism. Enzymology, Topology, and regulation

1 reference

12 December 2020

Modulation of neuritogenesis by ganglioside-specific sialidase (Neu 3) in human neuroblastoma NB-1 cells

1 reference

12 December 2020

Glycosylinositol phospholipid anchors of the scrapie and cellular prion proteins contain sialic acid

1 reference

12 December 2020

Gangliosides and Nogo receptors independently mediate myelin-associated glycoprotein inhibition of neurite outgrowth in different nerve cells

1 reference

12 December 2020

Gene therapy progress and prospects: gene therapy of lysosomal storage disorders

1 reference

12 December 2020

Myelin-Associated Glycoprotein Location and Potential Functions

1 reference

12 December 2020

Reduction of glycosphingolipid levels in lipid rafts affects the expression state and function of glycosylphosphatidylinositol-anchored proteins but does not impair signal transduction via the T cell receptor

1 reference

12 December 2020

Surface glycosyltransferase activities during development of neuronal cell cultures

1 reference

12 December 2020

Identification of plasma membrane associated mature β-hexosaminidase A, active towards GM2 ganglioside, in human fibroblasts

1 reference

12 December 2020

A glycosynapse in myelin?

1 reference

12 December 2020

GQ1b, a bioactive ganglioside that exhibits novel nerve growth factor (NGF)-like activities in the two neuroblastoma cell lines.

1 reference

12 December 2020

Prion rods contain small amounts of two host sphingolipids as revealed by thin-layer chromatography and mass spectrometry

1 reference

12 December 2020

Spatial segregation of gamma-secretase and substrates in distinct membrane domains

1 reference

12 December 2020

Glial inhibition of CNS axon regeneration

1 reference

12 December 2020

Glycolipid and ganglioside metabolism imbalances in Huntington's disease.

1 reference

12 December 2020

Brain lipid composition in grey-lethal mutant mouse characterized by severe malignant osteopetrosis

1 reference

12 December 2020

Aggregation and fibrillization of prions in lipid membranes

1 reference

12 December 2020

O-glycosylation of mucin-like domain retains the neutral ceramidase on the plasma membranes as a type II integral membrane protein

1 reference

12 December 2020

Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform

1 reference

12 December 2020

Sub-synaptosomal localization of brain particulate neuraminidase

1 reference

12 December 2020

Unraveling the differential expression of the two isoforms of myelin-associated glycoprotein in a mouse expressing GFP-tagged S-MAG specifically regulated and targeted into the different myelin compartments

1 reference

12 December 2020

Formation of a membrane-active form of amyloid beta-protein in raft-like model membranes

1 reference

12 December 2020

Enzyme therapy for lysosomal storage disease: principles, practice, and prospects

1 reference

12 December 2020

Inhibition of sphingolipid synthesis affects axonal outgrowth in cultured hippocampal neurons.

1 reference

12 December 2020

Differential functional relevance of a plasma membrane ganglioside sialidase in cholinergic and adrenergic neuroblastoma cell lines

1 reference

12 December 2020

The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein

1 reference

12 December 2020

Effect of brefeldin A on ganglioside metabolism in cultured neurons: implications for the intracellular traffic of gangliosides

1 reference

12 December 2020

Ganglioside changes in slow virus diseases: analyses of chimpanzee brains infected with kuru and Creutzfeldt-Jakob agents

1 reference

12 December 2020

Bicistronic lentiviral vector corrects beta-hexosaminidase deficiency in transduced and cross-corrected human Sandhoff fibroblasts.

1 reference

12 December 2020

Immunofluorescent Patterns of Dissociated Rat Embryo Cerebral Cells during Development in Surface Culture: Distinctive Reactions with Neurite and Perikaryon Cell Membranes

1 reference

12 December 2020

Role for up-regulated ganglioside biosynthesis and association of Src family kinases with microdomains in retinoic acid-induced differentiation of F9 embryonal carcinoma cells

1 reference

12 December 2020

GM1 specifically interacts with alpha-synuclein and inhibits fibrillation

1 reference

12 December 2020

Modulation of amyloid precursor protein cleavage by cellular sphingolipids

1 reference

12 December 2020

Up-and-down topological mode of amyloid beta-peptide lying on hydrophilic/hydrophobic interface of ganglioside clusters

1 reference

12 December 2020

Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II).

1 reference

12 December 2020

Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration

1 reference

12 December 2020

Sphingolipid metabolism diseases

1 reference

12 December 2020

Immunocytological studies of L-MAG expression regulation during myelination of embryonic brain cell cocultures.

1 reference

12 December 2020

Myelin-associated glycoprotein and its axonal receptors

1 reference

12 December 2020

G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.

1 reference

12 December 2020

Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor

1 reference

12 December 2020

Membrane-bound neuraminidase in the brain of different animals: behaviour of the enzyme on endogenous sialo derivatives and rationale for its assay

1 reference

12 December 2020

Cross-seeding of wild-type and hereditary variant-type amyloid beta-proteins in the presence of gangliosides.

1 reference

12 December 2020

Salvage of catabolic products in ganglioside metabolism: a study on rat cerebellar granule cells in culture.

1 reference

12 December 2020

Ganglioside composition changes in spongiform encephalopathies: analyses of 263K scrapie-infected hamster brains.

1 reference

12 December 2020

Ganglioside changes associated with temporal lobe epilepsy in the human hippocampus

1 reference

12 December 2020

Thermotropic characterization of phosphatidylcholine vesicles containing ganglioside GM1 with homogeneous ceramide chain length.

1 reference

12 December 2020

Inhibition of sphingolipid synthesis affects kinetics but not fidelity of L1/NgCAM transport along direct but not transcytotic axonal pathways

1 reference

12 December 2020

1 reference

12 December 2020

Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein

1 reference

12 December 2020

A vital role for glycosphingolipid synthesis during development and differentiation

1 reference

12 December 2020

Anabolic sialosylation of gangliosides in situ in rat brain cortical slices

1 reference

12 December 2020

Gangliosides and parkinsonism

1 reference

12 December 2020

Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells

1 reference

12 December 2020

Prion diseases and the BSE crisis

1 reference

12 December 2020

Cholesterol-dependent Generation of a Seeding Amyloid β-Protein in Cell Culture

1 reference

12 December 2020

Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications

1 reference

12 December 2020

Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein

1 reference

12 December 2020

Lipid rafts and integrin activation regulate oligodendrocyte survival.

1 reference

12 December 2020

The amyloid precursor protein interacts with Go heterotrimeric protein within a cell compartment specialized in signal transduction

1 reference

12 December 2020

Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity

1 reference

12 December 2020

Asymmetric membrane ganglioside sialidase activity specifies axonal fate.

1 reference

12 December 2020

Lipid composition of microdomains is altered in a cell model of Gaucher disease

1 reference

12 December 2020

GDNF recruits the signaling crew into lipid rafts

1 reference

12 December 2020

A regulatory role for sphingolipids in neuronal growth. Inhibition of sphingolipid synthesis and degradation have opposite effects on axonal branching.

1 reference

12 December 2020

Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide

1 reference

12 December 2020

Membrane lipids in the aging human brain.

1 reference

12 December 2020

Developmental patterns of ganglioside sialosylation coincident with neuritogenesis in cultured embryonic chick brain neurons

1 reference

12 December 2020

Aggregative properties of gangliosides in solution.

1 reference

12 December 2020

GM1 ganglioside-mediated accumulation of amyloid beta-protein on cell membranes

1 reference

12 December 2020

Exogenous gangliosides GD1b and GD1b-lactone, stably associated to rat brain P2 subcellular fraction, modulate differently the process of protein phosphorylation.

1 reference

12 December 2020

Lipid rafts in neuronal signaling and function.

1 reference

12 December 2020

A ganglioside-induced toxic soluble Abeta assembly. Its enhanced formation from Abeta bearing the Arctic mutation

1 reference

12 December 2020

Neuropeptides interact with glycolipid receptors: a surface plasmon resonance study

1 reference

12 December 2020

Neurotrophic and neuroprotective actions of an enhancer of ganglioside biosynthesis

1 reference

12 December 2020

Activity of plasma membrane beta-galactosidase and beta-glucosidase

1 reference

12 December 2020

Enhanced insulin sensitivity in mice lacking ganglioside GM3.

1 reference

12 December 2020

Identification of the glycosylated sequons of human myelin-associated glycoprotein

1 reference

12 December 2020

Nuclear Overhauser effect investigation on GM1 ganglioside containing N-glycolyl-neuraminic acid (II3Neu5GcGgOse4Cer).

1 reference

12 December 2020

Selective ganglioside desialylation in the plasma membrane of human neuroblastoma cells

1 reference

12 December 2020

Detergent-insoluble glycosphingolipid/cholesterol microdomains of the myelin membrane

1 reference

12 December 2020

Membrane lipids of adult human brain: lipid composition of frontal and temporal lobe in subjects of age 20 to 100 years.

1 reference

12 December 2020

Reorganization of prion protein membrane environment during low potassium-induced apoptosis in primary rat cerebellar neurons

1 reference

12 December 2020

On the chemistry and occurrence of sphingolipid long-chain bases

1 reference

12 December 2020

Gangliosides in the brain in adult Down's syndrome and Alzheimer's disease

1 reference

12 December 2020

Induction of cholinergic differentiation with neurite sprouting by de novo biosynthesis and expression of GD3 and b-series gangliosides in Neuro2a cells

1 reference

12 December 2020

10.1007/S12035-009-8096-6

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20127207%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference