The dopamine D4 receptor: biochemical and signalling properties (Q37694353)

22 August 2017

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title

The dopamine D4 receptor: biochemical and signalling properties (English)

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Kathleen Van Craenenbroeck

22 August 2017

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3

object named as

Kathleen Van Craenenbroeck

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author name string

Pieter Rondou

1

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PubMed ID

20165900

22 August 2017

Guy Haegeman

2

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PubMed ID

20165900

22 August 2017

Kathleen Van Craenenbroeck

3

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22 August 2017

18 February 2010

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Cellular and Molecular Life Sciences

22 August 2017

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22 August 2017

67

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22 August 2017

1971-1986

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22 August 2017

12

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https://scigraph.springernature.com/pub.10.1007/s00018-010-0293-y

22 August 2017

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cites work

Structure and function of proteins in G-protein-coupled signal transfer

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0293-Y

Dopamine receptor gene expression in the human medial temporal lobe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0293-Y

Dopamine receptor transcript expression in striatum and prefrontal and occipital cortex. Focal abnormalities in orbitofrontal cortex in schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0293-Y

Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0293-Y

Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0293-Y

Allelic Variation in the D4 Dopamine Receptor (DRD4) Gene Does Not Predict Response to Clozapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0293-Y

A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia.

21 January 2018

1 reference

12 December 2020

D4 dopamine receptor-mediated signaling events determined in transfected Chinese hamster ovary cells

1 reference

12 December 2020

Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.

1 reference

12 December 2020

Molecular diversity of the dopamine receptors

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12 December 2020

Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning

1 reference

12 December 2020

PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties.

1 reference

12 December 2020

Dopamine D(4) and D(2L) Receptor Stimulation of the Mitogen-Activated Protein Kinase Pathway Is Dependent on trans-Activation of the Platelet-Derived Growth Factor Receptor

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12 December 2020

Preferential Interaction between the dopamine D2 receptor and Arrestin2 in neostriatal neurons

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12 December 2020

Comparative pharmacological and functional analysis of the human dopamine D4.2 and D4.10 receptor variants.

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12 December 2020

Variability of dopamine D4 receptor (DRD4) gene sequence within and among nonhuman primate species

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12 December 2020

The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus

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12 December 2020

Lack of association between dopamine D4 receptor gene and schizophrenia

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12 December 2020

Human D2 and D4 dopamine receptors couple through betagamma G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respectively.

1 reference

12 December 2020

Lesion to the nigrostriatal dopamine system disrupts stimulus-response habit formation.

1 reference

12 December 2020

Cloning and expression of a rat D2 dopamine receptor cDNA

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12 December 2020

Cutting Edge: Stimulation of dopamine D4 receptors induce T cell quiescence by up-regulating Kruppel-like factor-2 expression through inhibition of ERK1/ERK2 phosphorylation

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12 December 2020

Distinct dynamin-dependent and -independent mechanisms target structurally homologous dopamine receptors to different endocytic membranes

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12 December 2020

Phosphorylation and palmitoylation of the human D2L dopamine receptor in Sf9 cells

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12 December 2020

Short- and long-term heterologous sensitization of adenylate cyclase by D4 dopamine receptors

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12 December 2020

A D2 class dopamine receptor transactivates a receptor tyrosine kinase to inhibit NMDA receptor transmission

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12 December 2020

Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats.

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12 December 2020

D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory

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12 December 2020

New insights into dopaminergic receptor function using antisense and genetically altered animals

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12 December 2020

Differential voltage-sensitivity of D2-like dopamine receptors

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12 December 2020

DARPP-32: molecular integration of phosphorylation potential.

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12 December 2020

Evolution and cell biology of dopamine receptors in vertebrates

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12 December 2020

DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1

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12 December 2020

Modulation of memory fields by dopamine D1 receptors in prefrontal cortex.

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12 December 2020

Levodopa therapy for Parkinson's disease: challenges and future prospects.

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12 December 2020

Drugs of abuse: anatomy, pharmacology and function of reward pathways

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12 December 2020

Dopamine D4 receptor and anxiety: behavioural profiles of clozapine, L-745,870 and L-741,742 in the mouse plus-maze

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12 December 2020

Neurobiology of schizophrenia

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12 December 2020

Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis

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12 December 2020

Cloning and characterization of the 5'-flanking region of the human dopamine D4 receptor gene.

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12 December 2020

Activity of striatal neurons reflects dynamic encoding and recoding of procedural memories

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12 December 2020

Autoradiographic localization of the putative D4 dopamine receptor in rat brain.

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12 December 2020

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

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12 December 2020

Dopamine D4 receptor isoform mRNA and protein are expressed in the rat cortical collecting duct

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12 December 2020

Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys.

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12 December 2020

SH3 binding domains in the dopamine D4 receptor

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12 December 2020

Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor

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12 December 2020

Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes

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12 December 2020

Dopamine D4 receptors modulate GABAergic signaling in pyramidal neurons of prefrontal cortex.

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12 December 2020

Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation

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12 December 2020

A network of dopaminergic gene variations implicated as risk factors for schizophrenia

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12 December 2020

Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism.

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12 December 2020

Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases

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12 December 2020

Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins

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12 December 2020

A search for association between schizophrenia and dopamine-related alleles

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12 December 2020

The dopamine D4 receptor activates intracellular platelet-derived growth factor receptor beta to stimulate ERK1/2.

1 reference

12 December 2020

Molecular genetics of attention-deficit/hyperactivity disorder

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12 December 2020

Dopamine D4 receptor mediated inhibition of potassium current in neurohypophysial nerve terminals.

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12 December 2020

BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase

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12 December 2020

Dopamine D4 receptors are heterogeneously distributed in the striosomes/matrix compartments of the striatum

1 reference

12 December 2020

An update on the genetics of schizophrenia

1 reference

12 December 2020

The genetics of attention-deficit/hyperactivity disorder

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12 December 2020

Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants

1 reference

12 December 2020

S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: I. Cellular, electrophysiological, and neurochemical profile in comparison with ropinirole.

1 reference

12 December 2020

Dopamine-sensitive adenyl cyclase: possible role in synaptic transmission

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12 December 2020

Neurobiology of addiction

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12 December 2020

When a G protein-coupled receptor does not couple to a G protein

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12 December 2020

Dopamine D4 receptors regulate AMPA receptor trafficking and glutamatergic transmission in GABAergic interneurons of prefrontal cortex

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12 December 2020

WAY-100635 is a potent dopamine D4 receptor agonist

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12 December 2020

Dopamine D2 and D4 receptor ligands: relation to antipsychotic action.

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12 December 2020

A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice.

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12 December 2020

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

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12 December 2020

Evidence that the dopamine D4 receptor is a susceptibility gene in attention deficit hyperactivity disorder

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12 December 2020

Differential regional and cellular distribution of dopamine D2-like receptors: an immunocytochemical study of subtype-specific antibodies in rat and human brain

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12 December 2020

Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor

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12 December 2020

Expression and pharmacological characterization of the human D3 dopamine receptor

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12 December 2020

Dopamine D(2) receptor activation causes mitogenesis via p44/42 mitogen-activated protein kinase in opossum kidney cells

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12 December 2020

Characterization of the desensitization properties of five dopamine receptor subtypes and alternatively spliced variants of dopamine D2 and D4 receptors

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12 December 2020

Structure and function of dopamine receptors

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12 December 2020

Dopamine D4 gene 7-repeat allele and attention deficit hyperactivity disorder

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12 December 2020

Development and characterization of antibodies against the N terminus of the human dopamine D4 receptor.

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12 December 2020

Two adjacent cysteine residues in the C-terminal cytoplasmic fragment of bovine rhodopsin are palmitylated

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12 December 2020

The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking.

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12 December 2020

Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist

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12 December 2020

Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine

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12 December 2020

Facilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice

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12 December 2020

Dopamine D4 receptors elevated in schizophrenia

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12 December 2020

Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD).

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12 December 2020

Dopaminergic signaling in dendritic spines

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12 December 2020

Dopamine activation of the arachidonic acid cascade as a basis for D1/D2 receptor synergism

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12 December 2020

G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase

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12 December 2020

Full-length cDNA cloning and distribution of human dopamine D4 receptor

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12 December 2020

Site-directed mutagenesis of the human dopamine D2 receptor

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12 December 2020

Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats

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12 December 2020

Dopamine responsiveness is regulated by targeted sorting of D2 receptors

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12 December 2020

Selective reconstitution of human D4 dopamine receptor variants with Gi alpha subtypes

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12 December 2020

Dopamine: 50 years in perspective

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12 December 2020

Layer V neurons bear the majority of mRNAs encoding the five distinct dopamine receptor subtypes in the primate prefrontal cortex.

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12 December 2020

Molecular genetics of attention-deficit hyperactivity disorder (ADHD): an update

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12 December 2020

Voltage-dependence of the human dopamine D2 receptor

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12 December 2020

Induced gamma-band activity during the delay of a visual short-term memory task in humans.

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12 December 2020

Pharmacological characterization of AC-90179 [2-(4-methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide hydrochloride]: a selective serotonin 2A receptor inverse agonist

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12 December 2020

Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat.

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12 December 2020

Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.

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12 December 2020

Identification of dopamine D4 receptor mRNA in circulating human lymphocytes using nested polymerase chain reaction

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12 December 2020

Dopamine receptor signaling

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12 December 2020

GPCR interacting proteins (GIP).

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12 December 2020

Distribution of D4 dopamine receptor in rat brain with sequence-specific antibodies.

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12 December 2020

[3H]S33084: a novel, selective and potent radioligand at cloned, human dopamine D3 receptors

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12 December 2020

D2, D3, and D4 dopamine receptors couple to G protein-regulated potassium channels in Xenopus oocytes.

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12 December 2020

Dopamine inhibits Na(+)-H+ exchanger activity in renal BBMV by stimulation of adenylate cyclase

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12 December 2020

Dopamine D4 receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective

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12 December 2020

Polymorphisms in dopamine receptors: what do they tell us?

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12 December 2020

WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation

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12 December 2020

The rat dopamine D4 receptor: sequence, gene structure, and demonstration of expression in the cardiovascular system

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12 December 2020

Localization of dopamine D4 receptors in GABAergic neurons of the primate brain

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12 December 2020

The dopamine D4 receptors and mechanisms of antipsychotic atypicality.

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12 December 2020

I. NGD 94-1: identification of a novel, high-affinity antagonist at the human dopamine D4 receptor.

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12 December 2020

Regulation of G protein-coupled receptor signaling by scaffold proteins

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12 December 2020

Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.

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12 December 2020

Development and characterization of antibodies directed against the mouse D4 dopamine receptor

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12 December 2020

Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor

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12 December 2020

PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain

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12 December 2020

Contributions of Conserved Serine Residues to the Interactions of Ligands with Dopamine D2 Receptors

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12 December 2020

Receptor density as a factor governing the efficacy of the dopamine D4 receptor ligands, L-745,870 and U-101958 at human recombinant D4.4 receptors expressed in CHO cells

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12 December 2020

Distinct functions of the two isoforms of dopamine D2 receptors

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12 December 2020

Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands

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12 December 2020

Receptor tyrosine kinase transactivation: fine-tuning synaptic transmission

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12 December 2020

Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes

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12 December 2020

Carbon-11 pb-12: an attempt to visualize the dopamine d(4) receptor in the primate brain with positron emission tomography

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12 December 2020

The dopamine D(4) receptor: one decade of research

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12 December 2020

Structure and function in rhodopsin: packing of the helices in the transmembrane domain and folding to a tertiary structure in the intradiscal domain are coupled

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12 December 2020

Investigation of the role of conserved serine residues in the long form of the rat D2 dopamine receptor using site-directed mutagenesis.

1 reference

12 December 2020

Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor.

1 reference

12 December 2020

The effects of a selective D4 dopamine receptor antagonist (L-745,870) in acutely psychotic inpatients with schizophrenia. D4 Dopamine Antagonist Group

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12 December 2020

RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice

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12 December 2020

Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor

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12 December 2020

Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking

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12 December 2020

Pivotal role for aspartate-80 in the regulation of dopamine D2 receptor affinity for drugs and inhibition of adenylyl cyclase

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12 December 2020

The neurobiology of dopamine signaling

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12 December 2020

A model for modulation of neuronal synchronization by D4 dopamine receptor-mediated phospholipid methylation.

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12 December 2020

Quantitative analysis of the dopamine D4 receptor in the mouse brain

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12 December 2020

A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent

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12 December 2020

D2 dopamine receptor stimulation of mitogenesis in transfected Chinese hamster ovary cells: relationship to dopamine stimulation of tyrosine phosphorylations.

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12 December 2020

Pharmacological characterization of extracellular acidification rate responses in human D2(long), D3 and D4.4 receptors expressed in Chinese hamster ovary cells

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12 December 2020

Protein-protein interactions at G-protein-coupled receptors

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12 December 2020

Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder.

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12 December 2020

Glycosylation, palmitoylation, and localization of the human D2S receptor in baculovirus-infected insect cells

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12 December 2020

The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task.

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12 December 2020

G(olf) and Gs in rat basal ganglia: possible involvement of G(olf) in the coupling of dopamine D1 receptor with adenylyl cyclase

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12 December 2020

Dopamine receptor functions: lessons from knockout mice [corrected].

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12 December 2020

How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis

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12 December 2020

Effects of L-745,870, a dopamine D4 receptor antagonist, on naloxone-induced morphine dependence in mice

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12 December 2020

Functional activation by central monoamines of human dopamine D(4) receptor polymorphic variants coupled to GIRK channels in Xenopus oocytes.

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12 December 2020

Coupling of dopamine receptor subtypes to multiple and diverse G proteins

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12 December 2020

Dopamine receptors: from structure to function

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12 December 2020

3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor

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12 December 2020

Characterization and distribution of [125I]epidepride binding to dopamine D2 receptors in basal ganglia and cortex of human brain

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12 December 2020

Distribution of 5-HT and DA receptors in primate prefrontal cortex: implications for pathophysiology and treatment

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12 December 2020

A selective dopamine D4 receptor antagonist, NRA0160: a preclinical neuropharmacological profile

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12 December 2020

Dopamine D4 receptor-deficient mice display cortical hyperexcitability

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12 December 2020

Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor

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12 December 2020

A hypervariable segment in the human dopamine receptor D4 (DRD4) gene.

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12 December 2020

Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit/hyperactivity disorder: genetic and brain morphometric analyses.

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12 December 2020

Plasticity and memory in the prefrontal cortex

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12 December 2020

Dopamine D2 long receptor-deficient mice display alterations in striatum-dependent functions

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12 December 2020

Dopamine D4 receptor-knock-out mice exhibit reduced exploration of novel stimuli.

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12 December 2020

D2 dopamine receptor expression and trafficking is regulated through direct interactions with ZIP

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12 December 2020

Noradrenaline and adrenaline are high affinity agonists at dopamine D4 receptors

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12 December 2020

Genotyping the -521C/T functional polymorphism in the promoter region of dopamine D4 receptor (DRD4) gene

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12 December 2020

Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking

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12 December 2020

Regional distribution of dopamine D4 receptors in rat forebrain.

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12 December 2020

Dopamine D4 receptor subtypes and response to clozapine

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12 December 2020

Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction

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12 December 2020

Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors

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12 December 2020

Desensitization of G protein-coupled receptors and neuronal functions

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12 December 2020

Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites

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12 December 2020

D(4) dopamine receptor differentially regulates Akt/nuclear factor-kappa b and extracellular signal-regulated kinase pathways in D(4)MN9D cells.

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12 December 2020

Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats

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12 December 2020

D2S, D2L, D3, and D4 dopamine receptors couple to a voltage-dependent potassium current in N18TG2 x mesencephalon hybrid cell (MES-23.5) via distinct G proteins

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12 December 2020

Association of the dopamine receptor D4 (DRD4) gene with a refined phenotype of attention deficit hyperactivity disorder (ADHD): a family-based approach

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12 December 2020

Iloperidone binding to human and rat dopamine and 5-HT receptors

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12 December 2020

Dopamine D4 receptors

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12 December 2020

G protein coupling and ligand selectivity of the D2L and D3 dopamine receptors.

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12 December 2020

[35S]Guanosine-5'-O-(3-thio)triphosphate binding as a measure of efficacy at human recombinant dopamine D4.4 receptors: actions of antiparkinsonian and antipsychotic agents.

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12 December 2020

II. Localization and characterization of dopamine D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1.

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12 December 2020

Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors

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12 December 2020

Resistance of the dopamine D4 receptor to agonist-induced internalization and degradation

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12 December 2020

The influence of environment and experience on neural grafts.

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12 December 2020

Toward a new understanding of attention-deficit hyperactivity disorder pathophysiology: an important role for prefrontal cortex dysfunction

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12 December 2020

Cellular distribution of the rat D4 dopamine receptor protein in the CNS using anti-receptor antisera

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12 December 2020

The principal features and mechanisms of dopamine modulation in the prefrontal cortex

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12 December 2020

Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data

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12 December 2020

Multiple dopamine D4 receptor variants in the human population

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12 December 2020

Evidence of positive selection acting at the human dopamine receptor D4 gene locus

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12 December 2020

[(3)H]PNU-101958, a D(4) dopamine receptor probe, accumulates in prefrontal cortex and hippocampus of non-human primate brain

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12 December 2020

10.1007/S00018-010-0293-Y

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20165900