Methylseleninic acid elevates REDD1 and inhibits prostate cancer cell growth despite AKT activation and mTOR dysregulation in hypoxia (Q37703369)

22 August 2017

Methylseleninic acid elevates REDD1 and inhibits prostate cancer cell growth despite AKT activation and mTOR dysregulation in hypoxia (English)

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22 August 2017

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ChEBI release 2020-05-28

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Indu Sinha

1

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22 August 2017

Joshua E Allen

series ordinal

2

1 reference

22 August 2017

John T Pinto

series ordinal

3

1 reference

22 August 2017

Raghu Sinha

series ordinal

4

1 reference

22 August 2017

language of work or name

English

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publication date

7 February 2014

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22 August 2017

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22 August 2017

3

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22 August 2017

2

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22 August 2017

252-264

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describes a project that uses

22 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3987075/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Regulated in development and DNA damage responses -1 (REDD1) protein contributes to insulin signaling pathway in adipocytes

23 August 2017

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Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment

23 August 2017

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Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition

23 August 2017

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Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

23 August 2017

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1,4-phenylenebis(methylene)selenocyanate, but not selenomethionine, inhibits androgen receptor and Akt signaling in human prostate cancer cells

23 August 2017

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Chemopreventive mechanisms of α-keto acid metabolites of naturally occurring organoselenium compounds

23 August 2017

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Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis

23 August 2017

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23 August 2017

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Methylselenol, a selenium metabolite, induces cell cycle arrest in G1 phase and apoptosis via the extracellular-regulated kinase 1/2 pathway and other cancer signaling genes

23 August 2017

1 reference

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Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells

23 August 2017

1 reference

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REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase

23 August 2017

1 reference

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Measurement of sulfur-containing compounds involved in the metabolism and transport of cysteamine and cystamine. Regional differences in cerebral metabolism.

23 August 2017

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Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit

23 August 2017

1 reference

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Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1.

23 August 2017

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23 August 2017

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Hypoxia in prostate cancer: a powerful shield against tumour destruction?

23 August 2017

1 reference

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Superior in vivo inhibitory efficacy of methylseleninic acid against human prostate cancer over selenomethionine or selenite.

23 August 2017

1 reference

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Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

23 August 2017

1 reference

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Regulation of mTOR and cell growth in response to energy stress by REDD1.

23 August 2017

1 reference

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The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway

23 August 2017

1 reference

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REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase.

23 August 2017

1 reference

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The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

23 August 2017

1 reference

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Akt stimulates aerobic glycolysis in cancer cells

23 August 2017

1 reference

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Apoptosis is a critical cellular event in cancer chemoprevention and chemotherapy by selenium compounds

23 August 2017

1 reference

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Hypoxia--a key regulatory factor in tumour growth

23 August 2017

1 reference

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Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.

23 August 2017

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Antiangiogenic activity of selenium in cancer chemoprevention: metabolite-specific effects

23 August 2017

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Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

23 August 2017

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Pathogenic role of HIF-1α in prostate hyperplasia in the presence of chronic inflammation

23 August 2017

1 reference

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Selenium inhibits migration of murine melanoma cells via down-modulation of IL-18 expression

6 September 2017

1 reference

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Effects of naturally occurring and synthetic organoselenium compounds on protein profiling in androgen responsive and androgen independent human prostate cancer cells.

6 September 2017

1 reference

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Methylseleninic acid downregulates hypoxia-inducible factor-1α in invasive prostate cancer.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

HIF-dependent antitumorigenic effect of antioxidants in vivo

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

Selective modulation of the therapeutic efficacy of anticancer drugs by selenium containing compounds against human tumor xenografts

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

Inhibition of cdk2 kinase activity by methylselenocysteine in synchronized mouse mammary epithelial tumor cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

Induction of caspase-mediated apoptosis and cell-cycle G1 arrest by selenium metabolite methylselenol

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

Inhibitory effects of selenium on the growth of DU-145 human prostate carcinoma cells in vitro.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

Differential effects of naturally occurring and synthetic organoselenium compounds on biomarkers in androgen responsive and androgen independent human prostate carcinoma cells.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

Plasma selenium level before diagnosis and the risk of prostate cancer development

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3987075

Prediagnostic serum selenium and risk of cancer

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24515947

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24515947

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/CAM4.198

1 reference

22 August 2017

1 reference

22 August 2017

1 reference