Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease. (Q37706391)

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scientific article published on 31 December 2013

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English	Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.	scientific article published on 31 December 2013

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scholarly article

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4 March 2020

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease (English)

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4 March 2020

Parkinson's disease

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inferred from title

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based on heuristic

inferred from title

Penelope J. Hallett

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4 March 2020

3

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4 March 2020

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4 March 2020

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4 March 2020

George K Tofaris

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4 March 2020

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Sian E Davies

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4 March 2020

Emily Mangano

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4 March 2020

Hyoung Tae Kim

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4 March 2020

Alfred L Goldberg

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4 March 2020

Ji-Long Liu

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4 March 2020

publication date

31 December 2013

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4 March 2020

Neurobiology of Disease

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4 March 2020

64

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4 March 2020

79-87

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4 March 2020

Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988924

23 August 2017

Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation

1 reference

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Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning

1 reference

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23 August 2017

A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila

1 reference

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23 August 2017

Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway

1 reference

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α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies

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CNS expression of glucocerebrosidase corrects alpha-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy

1 reference

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23 August 2017

Calcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibition

1 reference

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Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression

1 reference

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23 August 2017

Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation

1 reference

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23 August 2017

Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.

1 reference

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23 August 2017

Physiological functions of the HECT family of ubiquitin ligases

1 reference

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23 August 2017

Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988924

23 August 2017

Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988924

23 August 2017

Whole genome survey of coding SNPs reveals a reproducible pathway determinant of Parkinson disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988924

23 August 2017

Genomic investigation of alpha-synuclein multiplication and parkinsonism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988924

23 August 2017

Physiological and pathological properties of alpha-synuclein

1 reference

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23 August 2017

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

1 reference

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23 August 2017

Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury.

1 reference

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23 August 2017

Dopamine covalently modifies and functionally inactivates parkin

1 reference

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23 August 2017

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988924

23 August 2017

A nonconserved Ala401 in the yeast Rsp5 ubiquitin ligase is involved in degradation of Gap1 permease and stress-induced abnormal proteins

1 reference

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23 August 2017

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

1 reference

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23 August 2017

A Drosophila model of Parkinson's disease

1 reference

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23 August 2017

Lysosome-dependent pathways as a unifying theme in Parkinson's disease.

1 reference

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6 September 2017

New stereological methods for counting neurons

1 reference

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28 September 2017

Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.

1 reference

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1 September 2018

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988924

1 September 2018

Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988924

1 September 2018

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988924

1 September 2018

alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988924

1 September 2018

Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson Disease

1 reference

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3 December 2018

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10.1016/J.NBD.2013.12.011

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4 March 2020

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4 March 2020

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4 March 2020

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